Echocardiographic determinants of left ventricular ejection fraction after acute myocardial infarction

McClements, Brian M.; Weyman, Arthur E.; Picard, Michael H.

doi:10.1067/mhj.2000.107543

Cited by 22 publications

(13 citation statements)

References 24 publications

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“…Thus, myocardial damage of equal size affects EF to a greater degree in the anterior than in the inferior wall. 35) This could partly explain the additional prognostic value of the Tei index.…”

Section: Discussionmentioning

confidence: 99%

Correlation of the Tei Index With Left Ventricular Dilatation and Mortality in Patients With Acute Myocardial Infarction

Uzunhasan

Okçun

et al. 2006

Int. Heart J.

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SUMMARYThe Tei index is an echocardiographic index of combined systolic and diastolic function, calculated as isovolumetric relaxation time plus isovolumetric contraction time divided by ejection time. The aim of this study was to define the correlation of the Tei index with left ventricular dilatation and mortality in patients with acute myocardial infarction (AMI).A total of 77 patients (58 men, 19 women) with a mean age of 53 ± 12 years, who had presented with an AMI in our clinic between June 2001 and February 2002 were compared with a control group of 88 healthy subjects (63 men, 25 women) with a mean age of 55 ± 6 years. Echocardiographic evaluation was carried out within 24 hours and the third month of AMI, using a 3.5 MHz probe with pulse wave Doppler recordings by the adult cardiac mode of an Acuson C 256 echocardiograph.There were statistically significant differences between the 2 groups in all echocardiographic parameters, except mitral A wave. Thirteen patients died during the follow-up period of 3 months. The Tei index was significantly higher in the patients who died compared with those who survived (0.70 ± 0.10 versus 0.61 ± 0.10; P < 0.001). The patients who had heart failure after AMI had a mean Tei index value of 0.76 ± 0.27, whereas the patients who did not have heart failure after AMI had a significantly lower Tei index value of 0.60 ± 0.32 (P < 0.05). Patients were divided into 2 groups according to their Tei index. Patients with a > 0.60 Tei index had significantly higher end-systolic and enddiastolic volumes compared to patients with a < 0.60 Tei index (P < 0.001 for both) in the acute phase of AMI. Within 3 months, patients with a Tei index < 0.60 had a significant reduction in end-diastolic volumes (P < 0.01), whereas the end-diastolic volumes did not change significantly in patients with an index > 0.60 (P = 0.19).The Tei index is an important indicator of left ventricular dysfunction and death after AMI. A greater Tei index at the onset of AMI is associated with a higher incidence of subsequent cardiac death, CHF, and progressive LV remodeling. (Int Heart J 2006; 47: 331-342)

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Section: Discussionmentioning

confidence: 99%

Correlation of the Tei Index With Left Ventricular Dilatation and Mortality in Patients With Acute Myocardial Infarction

Uzunhasan

Okçun

et al. 2006

Int. Heart J.

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“…11,12 Previous studies have shown that anterior wall STEMI has higher risk of inhospital stroke. 14,19,20 Patients with anterior wall STEMI are more likely to have low ejection fraction, 21 and the incidence of left ventricular mural thrombus is higher, 22 which might account for the higher risk of stroke in those populations. The results of our study are generally in line with those previous reports, except for the absence of upstream use of GP IIb/IIIa inhibitors as a risk factor.…”

Section: Risk Factors For Stroke Complicating Pcimentioning

confidence: 99%

Stroke Complicating Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction

Kawamura

Lombardi

Tilem

et al. 2007

Circ J

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“…First, the location of the infarct on the site of vessel occlusion is known to affect the improvement of LV dysfunction, [13][14][15][16] and clinical studies have shown that the LV ejection fraction is lower in anterior myocardial infarction (MI) than the inferior or lateral MI of the same infarct size. 17,18 Second, the infarct location was similar to the experimental models in which the profound effect of cell therapy was shown. 2,3,19 To avoid the dilution of any treatment effect, we excluded patients who presented within 2 h of symptom onset or patients with other small infarctions.…”

Section: Patientsmentioning

confidence: 62%

“…We were also concerned about the location of infarct and the site of vessel occlusion, which is known to affect the improvement of LV function and has been strictly controlled in successful animal models. [13][14][15][16][17][18] To overcome the potential bias described above, we enrolled only patients with proximal to mid LAD infarction. All our patients had a similar vessel occlusion site and large infarction size, which is most alike to the experimental models in which the profound effects of cell therapy were shown.…”

Section: Benefit Of Post-pci Cell Therapy In Ami Patientsmentioning

confidence: 99%

Lack of Additional Benefit of Intracoronary Transplantation of Autologous Peripheral Blood Stem Cell in Patients With Acute Myocardial Infarction

Choi

Lee

Rhee

et al. 2007

Circ J

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Background Recently the potential of myocardial repair by transplantation of autologous bone marrow stem cells has been suggested. Whether the additional intracoronary transplantation of autologous peripheral blood stem cells (PBSC), which were mobilized by granulocyte-colony-stimulating factor (G-CSF), could safely improve myocardial function in patients with acute myocardial infarction (AMI) was investigated. Methods and ResultsSeventy-three patients with AMI who had successfully undergone percutaneous coronary intervention (PCI) were enrolled in the present prospective nonrandomized open-labeled study. Ten patients with elective PCI received G-CSF for 4 days followed by intracoronary PBSC transplantation. Thirty-two patients with primary PCI and 31 patients with recent AMI and elective PCI served as controls. The left ventricular (LV) function was evaluated using echocardiography and magnetic resonance imaging. G-CSF and intracoronary transplantation of PBSC did not incur any periprocedural myocardial damage. After 6 months, the LV ejection fraction was significantly improved in the cell therapy group. For 2 years of the follow-up period, there was no adverse clinical events, except one asymptomatic in-stent restenosis. However, comparable improvement of the LV ejection fraction was also identified in the primary PCI and elective PCI control groups. Conclusions In the present study, additional intracoronary infusion of PBSC was safe and feasible for the patients with AMI who had undergone PCI, but did not lead to a significant improvement in LV function compared to standard reperfusion treatment. (Circ J 2007; 71: 486 -494)

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Echocardiographic determinants of left ventricular ejection fraction after acute myocardial infarction

Cited by 22 publications

References 24 publications

Correlation of the Tei Index With Left Ventricular Dilatation and Mortality in Patients With Acute Myocardial Infarction

Correlation of the Tei Index With Left Ventricular Dilatation and Mortality in Patients With Acute Myocardial Infarction

Stroke Complicating Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction

Lack of Additional Benefit of Intracoronary Transplantation of Autologous Peripheral Blood Stem Cell in Patients With Acute Myocardial Infarction

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