Echocardiographic Correlation between Right Ventricular Function and Left Atrial Volume

Baroncini, Liz Andréa Villela; Borges, Lucas José Lira; Camarozano, Ana Cristina; Carmo, Daniela de Castro; Darwich, Rubens Zenóbio; Fortunato, Jerônimo Antonio

doi:10.5935/abc.20190042

Cited by 3 publications

(3 citation statements)

References 30 publications

(30 reference statements)

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“…We found that reduced peak diastolic strain rates were associated with reduced LAV max i . Left atrial function was related to indicators of right ventricular function emphasising their functional interdependence 11 .…”

Section: Resultsmentioning

confidence: 99%

Genetic and environmental determinants of diastolic heart function

et al. 2022

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Diastole is the sequence of physiological events that occur in the heart during ventricular filling and principally depends on myocardial relaxation and chamber stiffness. Abnormal diastolic function is related to many cardiovascular disease processes and is predictive of health outcomes, but its genetic architecture is largely unknown. Here, we use machine-learning cardiac motion analysis to measure diastolic functional traits in 39,559 participants of the UK Biobank and perform a genome-wide association study. We identified nine significant, independent loci near genes that are associated with maintaining sarcomeric function under biomechanical stress and genes implicated in the development of cardiomyopathy. Age, sex and diabetes were independent predictors of diastolic function and we found a causal relationship between genetically determined ventricular stiffness and incident heart failure. Our results provide insights into the genetic and environmental factors influencing diastolic function that are relevant for identifying causal relationships and potential tractable targets.

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Section: Resultsmentioning

confidence: 99%

Genetic and environmental determinants of diastolic heart function

et al. 2022

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“…We found that reduced peak diastolic strain rates were associated with reduced LAVmax i . Left atrial function was related to indicators of right ventricular function emphasising their functional interdependence 15 .…”

Section: Resultsmentioning

confidence: 99%

Genetic and environmental determinants of diastolic heart function

Thanaj

Mielke

et al. 2021

Preprint

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Diastole is the sequence of physiological events that occur in the heart during ventricular filling and principally depends on myocardial relaxation and chamber stiffness. Abnormal diastolic function is related to many cardiovascular disease processes and is predictive of health outcomes, but its genetic architecture is largely unknown. Here, we use machine learning cardiac motion analysis to measure diastolic functional traits in 39,559 participants of UK Biobank and perform a genome-wide association study. We identified 9 significant, independent loci near genes that are associated with maintaining sarcomeric function under biomechanical stress and genes implicated in the development of cardiomyopathy. Age, sex and diabetes were independent predictors of diastolic function and we found a causal relationship between ventricular stiffness and heart failure. Our results provide novel insights into the genetic and environmental factors influencing diastolic function that are relevant for identifying causal relationships and tractable targets in heart failure.

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“…Although results obtained in our study have shown that presence of at least one variant, GPX1 *T or GPX3 *C allele, reduces the odds of developing cardiac manifestations in longCOVID-19, such results are in concordance with the significant association of those genetic variants with the changes in the echocardiographic parameters of the right ventricle and the left atrium. These findings have additional importance, since the right ventricular dysfunction and the left atrial enlargement represent one of the most important features of left ventricular diastolic dysfunction [ 35 ]. Hence, it could be speculated that recovered COVID-19 patients, who are carriers of referent GPX1 or GPX3 alleles, are more prone to developing LV diastolic impairment.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Genetic Variants Modify Echocardiography Indices in Long COVID

Ašanin

Ercegovac

Krljanać

et al. 2023

IJMS

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Although disturbance of redox homeostasis might be responsible for COVID-19 cardiac complications, this molecular mechanism has not been addressed yet. We have proposed modifying the effects of antioxidant proteins polymorphisms (superoxide dismutase 2 (SOD2), glutathione peroxidase 1 (GPX1), glutathione peroxidase 3 (GPX3) and nuclear factor erythroid 2-related factor 2, (Nrf2)) in individual susceptibility towards the development of cardiac manifestations of long COVID-19. The presence of subclinical cardiac dysfunction was assessed via echocardiography and cardiac magnetic resonance imaging in 174 convalescent COVID-19 patients. SOD2, GPX1, GPX3 and Nrf2 polymorphisms were determined via the appropriate PCR methods. No significant association of the investigated polymorphisms with the risk of arrhythmia development was found. However, the carriers of variant GPX1*T, GPX3*C or Nrf2*A alleles were more than twice less prone for dyspnea development in comparison with the carriers of the referent ones. These findings were even more potentiated in the carriers of any two variant alleles of these genes (OR = 0.273, and p = 0.016). The variant GPX alleles were significantly associated with left atrial and right ventricular echocardiographic parameters, specifically LAVI, RFAC and RV-EF (p = 0.025, p = 0.009, and p = 0.007, respectively). Based on the relation between the variant SOD2*T allele and higher levels of LV echocardiographic parameters, EDD, LVMI and GLS, as well as troponin T (p = 0.038), it can be proposed that recovered COVID-19 patients, who are the carriers of this genetic variant, might have subtle left ventricular systolic dysfunction. No significant association between the investigated polymorphisms and cardiac disfunction was observed when cardiac magnetic resonance imaging was performed. Our results on the association between antioxidant genetic variants and long COVID cardiological manifestations highlight the involvement of genetic propensity in both acute and long COVID clinical manifestations.

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Echocardiographic Correlation between Right Ventricular Function and Left Atrial Volume

Cited by 3 publications

References 30 publications

Genetic and environmental determinants of diastolic heart function

Genetic and environmental determinants of diastolic heart function

Genetic and environmental determinants of diastolic heart function

Antioxidant Genetic Variants Modify Echocardiography Indices in Long COVID

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