Echo Virus Type 7 Infections in a Continuously Observed Population Group in Southern Louisiana *

Adapted ECHO-7 virus Rigvir immunotherapy (oncolytic virotherapy) prolongs survival in melanoma patients after surgical excision of the tumour in a retrospective study

“…When tested in 155 adult cancer patients who had not been treated with Rigvir, neutralising antibodies against ECHO-7 were detected in ∼50% of the patients 41 . In a local study of 472 individuals, the presence of ECHO-7 antibodies was shown to increase with age in children and level off to a plateau of around 75% in adults 42 . To our knowledge, the prevalence of neutralising antibodies against the ECHO-7 virus in the general adult population has not been reported.…”

Echovirus Type 7 Meningitis in Young Children

“…COMMENT Echovirus type 7 was first isolated and identified in stool-specimen sur¬ veys of normal children during the early 1950s.1 -Subsequently, it has been shown that infection in infants and children is common and that near¬ ly two thirds of the population over 10 years of age possess antibody. '-'- 11 Despite the widespread nature of echovirus type 7, epidemics of clinical illness associated with this agent have been infrequent. Extensive reviews of viral infections of the CNS12·13 or of diseases associated with enteroviruses141' commonly fail to mention any cases of meningitis associated with this agent.…”

Infectious Diseases: Annual Review of Significant Publications

“…13 ECHO viruses caused febrile abdominalgia,14 exanthems,15' " meningoencephalitiS,12 17 mesenteric adenitis,18 and respiratory tract disease (ERC virus).19 ' 20, 21 ECHO viruses often are commensal, but cause inapparent epidemics detectable only by serologic means. 22 Coxsackie viruses caused pleurodynia,23 polio-like meningoencephalitis, respiratory tract disease, 24 25,26 pericarditis, myocarditis, nodular pharyngitis,27 peritonitis, mesenteric lymphadenitis,18' 28 exanthems,29 and probably hepatitis.30 Enteroviruses caused summer exanthems in children oftener than measles or varicella.29 At least 17 different enteroviruses were implicated as causes of 50°' of patients with meningoencephalitis.31 The matter was reviewed elsewhere.32 Enteroviruses present in wading pools -were killed by chlorination. 33 Children in hospitals may acquire enteroviruses from other patients.…”

“…Antimicrobics have reduced the seriousness and death rate of infections that are amenable to treatment. The mortality rate of pneumonia in general was reduced from 80 to 22 per oo00,000 between 1930 and 1954, owing chiefly to the cure of pneumococcal infections. Since then, unfortunately, the mortality rate of pneumonias of other cause has increased steadily to about 30 per 100,000 in I962 because of the increased incidence of infections caused by antimicrobic-resistant bacteria.143…”