Echinacoside inhibits breast cancer cells by suppressing the Wnt/β-catenin signaling pathway

Tang, Chenghuai; Gong, Liuping; Xu, lvzi; Qiu, Kaijin; Zhong, Zhou; Wan, Lihua

doi:10.1016/j.bbrc.2020.03.050

Cited by 40 publications

(24 citation statements)

References 28 publications

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“…Gigantol, a bibenzyl compound from orchid species, was also reported to inhibit Wnt/β-catenin signaling through down-regulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells [105]. Additionally, treatment of echinacoside, a phenylethanoid glycoside from Tibetan herbs, significantly reduced tumor growth and regulation of Wnt/β-catenin signaling [106]. Besides, nimbolide, a limonoid present in leaves of the neem tree, concurrently abrogated canonical Wnt signaling and induced intrinsic apoptosis in hepatocarcinoma cells [107].…”

Section: Natural Agents and New Activity Of Old Drugsmentioning

confidence: 99%

Targeting the Wnt/β-catenin signaling pathway in cancer

2020

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The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response. Accumulated investigations highlight the therapeutic potential of agents targeting Wnt/β-catenin signaling in cancer. Wnt ligand/ receptor interface, β-catenin destruction complex and TCF/β-catenin transcription complex are key components of the cascade and have been targeted with interventions in preclinical and clinical evaluations. This scoping review aims at outlining the latest progress on the current approaches and perspectives of Wnt/β-catenin signaling pathway targeted therapy in various cancer types. Better understanding of the updates on the inhibitors, antagonists and activators of Wnt/β-catenin pathway rationalizes innovative strategies for personalized cancer treatment. Further investigations are warranted to confirm precise and secure targeted agents and achieve optimal use with clinical benefits in malignant diseases.

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Section: Natural Agents and New Activity Of Old Drugsmentioning

confidence: 99%

Targeting the Wnt/β-catenin signaling pathway in cancer

2020

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“…On the other hand, the Wnt/β-catenin signaling pathway plays a significant role in cancer development [109][110][111]. Antitumor drugs such as echinacoside diminish the malignancy and proliferation of cancer cells via Wnt inhibition [112]. Besides, miR-455-3p inhibits EMT and the invasion of cancer cells via downregulation of Wnt/β-catenin [112].…”

Section: Nobiletin and Chemotherapymentioning

confidence: 99%

Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways

et al. 2020

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Cancer therapy is a growing field, and annually, a high number of research is performed to develop novel antitumor drugs. Attempts to find new antitumor drugs continue, since cancer cells are able to acquire resistance to conventional drugs. Natural chemicals can be considered as promising candidates in the field of cancer therapy due to their multiple-targeting capability. The nobiletin (NOB) is a ubiquitous flavone isolated from Citrus fruits. The NOB has a variety of pharmacological activities, such as antidiabetes, antioxidant, anti-inflammatory, hepatoprotective, and neuroprotective. Among them, the antitumor activity of NOB has been under attention over recent years. In this review, we comprehensively describe the efficacy of NOB in cancer therapy. NOB induces apoptosis and cell cycle arrest in cancer cells. It can suppress migration and invasion of cancer cells via the inhibition of epithelial-to-mesenchymal transition (EMT) and EMT-related factors such as TGF-β, ZEB, Slug, and Snail. Besides, NOB inhibits oncogene factors such as STAT3, NF-κB, Akt, PI3K, Wnt, and so on. Noteworthy, onco-suppressor factors such as microRNA-7 and -200b undergo upregulation by NOB in cancer therapy. These onco-suppressor and oncogene pathways and mechanisms are discussed in this review.

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“…and nucleus (active β-catenin) to regulate target factors and activate target genes in Wnt pathway. 48,49) In short, the total β-catenin, which accumulated in the cytoplasm, could enter the nucleus as its active form, known as the active β-catenin, and then combined with lymphocyte factor/lymphotropic factor (LEF/TCF), which can activate target genes of the Wnt signaling pathway, increasing pro-fibrogenic cytokines and protein expression of EMC compounds in HF. 50,51) Our previous studies have shown that Akt could directly activate phospho-GSK-3β, a critical protein in the pathophysiological process of HF.…”

Section: Biological and Pharmaceutical Bulletin Advance Publicationmentioning

confidence: 99%

Galangin Reverses Hepatic Fibrosis by Inducing HSCs Apoptosis <i>via</i> the PI3K/Akt, Bax/Bcl-2, and Wnt/β-Catenin Pathway in LX-2 Cells

Xiong

Lü

2020

Biological & Pharmaceutical Bulletin

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Hepatic fibrosis (HF) is a common disease, with currently no available treatment.Galangin, a natural flavonoid extracted from Alpinia officinaruim Hance, has multiple effects demonstrated in previous studies. The aim of the present study was to explore the anti-fibrogenic effect of galangin in vitro, and research its potential molecular mechanisms. LX-2 cells were chosen as an in vitro HF model, and were treated with galangin in different concentrations. Cell viability was analyzed using Cell Counting Kit-8 (CCK-8) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, cell apoptosis was measured using flow cytometry, and the anti-fibrogenic effect of galangin was determined using quantitative reverse transcription polymerase chain reaction (RT-qPCR), immunofluorescence, and western blotting. The results show that the proliferation of LX-2 cells was efficiently inhibited by galangin, and apoptosis was induced in a dose-dependent manner. Both the mRNA and protein expression of α-SMA and collagen I were markedly downregulated. Galangin also inhibited the PI3K/Akt and Wnt/β-catenin signaling pathways and increased the Bax/Bcl-2 ratio. The results of this study suggest that galangin has an anti-fibrogenic effect and may represent a promising agent in the treatment of hepatic fibrosis.

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Echinacoside inhibits breast cancer cells by suppressing the Wnt/β-catenin signaling pathway

Cited by 40 publications

References 28 publications

Targeting the Wnt/β-catenin signaling pathway in cancer

Targeting the Wnt/β-catenin signaling pathway in cancer

Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways

Galangin Reverses Hepatic Fibrosis by Inducing HSCs Apoptosis <i>via</i> the PI3K/Akt, Bax/Bcl-2, and Wnt/β-Catenin Pathway in LX-2 Cells

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