ECG-Induced Koebner Phenomenon

Streit, Enrico; Vogelgsang, Lena

doi:10.1056/nejmicm1706993

Cited by 7 publications

(6 citation statements)

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“…The presence of psoriatic lesions in those body areas, which are not usually affected by psoriasis suggest the key role of Koebner phenomenon in spreading psoriasis [13,14,31]. There is wide variety of triggers/agents that may induce Koebernization such as irradiations [44], Mantoux test [46,47], surgical incision [19,48], needle puncture [49], prosthesis [50], secondary syphilis [51], cupping therapy [52,53], ECG [55], itching [56], and viral infections [57]. Regarding role of injury in initiating Koebernization, the deep tissue injury is more critical and superficial injury alone is not sufficient to induce the development of new psoriatic lesions [58][59][60].…”

Section: Summarized Discussionmentioning

confidence: 99%

“…However, a large number of studies have shown the development of new psoriatic lesions after tattooing skin as a Koebner reaction [18,[39][40][41][42][43]. The other factors/agents that are reported to exacerbate psoriasis as Koebner reaction include megavoltage irradiations [44], radiotherapy for carcinoma of breast [45], exposure to purified protein derivative (PPD)/Mantoux test [46,47], surgical incision during breast reconstruction [19,48], needle acupuncture [49], prosthesis after amputation of the leg [50], secondary syphilis [51], cupping therapy, a traditional Chinese medicine [52,53], striae distensae and striae gravidarum [17,54], ECG [55], itching (one of the core features of psoriasis)-induced skin injury [56], and viral infection-induced hand-foot-and-mouth disease [57].…”

Section: Agents That May Trigger New Psoriatic Lesions In Uninvolved mentioning

confidence: 99%

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Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms

Liu

2019

Bioscience Reports

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Koebner phenomenon refers to the emergence of new psoriatic lesions in the healthy skin regions following an injury/trauma to psoriatic patients. The occurrence of psoriatic lesions at unusual areas of the body regions such as on penis, around eyes and on keloids suggest that the Koebner phenomenon may be responsible for these lesions. A number of agents/triggers have been reported to induce the development of new psoriatic lesions in healthy skin areas and these include, tattooing skin, radiations, skin incision, viral infections and striae etc. The different mechanisms that contribute in inducing the development of new psoriatic lesions as Koebernization include the involvement of mast cell-derived inflammatory mediators such as tryptase, IL-6, IL-8, IL-17, and IL-36γ. Moreover, an increased expression of nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) also contribute in Koebernization. Apart from these, there is a critical role of α 2 β1 integrins, S100A7 (psoriasin) and S100A15 (koebnerisin), change in the ratio of CD4+/CD8+ T cells, down-regulation of mechanosensitive polycystin 1 protein, decrease in inflammation controlling atypical chemokine receptor 2 (ACKR2), reduced expression of N-methyl-d-aspartate (NMDA) receptors (NMDARs) on the keratinocytes and increase in levels of chemokines (CXCL8 and CCL20) in inducing formation of new psoriatic lesions. The present review discusses the role of Koebner phenomenon in the development of new psoriatic lesions. Moreover, it also describes the mechanisms involved in Koebernization in the form of discussion of different key targets that may be potentially modulated pharmacologically to attenuate/halt the development of new psoriatic lesions.

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Section: Summarized Discussionmentioning

confidence: 99%

Section: Agents That May Trigger New Psoriatic Lesions In Uninvolved mentioning

confidence: 99%

Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms

Liu

2019

Bioscience Reports

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“…In patients with psoriasis, skin lesions appear in uninvolved areas after various injuries [13,14,15,16]; this is known as the Koebner phenomenon. Radiotherapy, ultraviolet (UV) B, and even a slight skin irritation have been reported to trigger new lesions of psoriasis [17,18,19]. However, psoriatic lesions are not always observed in the uninvolved skin after injuries [20,21].…”

Section: Extrinsic Risk Factorsmentioning

confidence: 99%

Risk Factors for the Development of Psoriasis

Kamiya

Kishimoto

Sugai

et al. 2019

IJMS

388

306

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Psoriasis is an immune-mediated genetic skin disease. The underlying pathomechanisms involve complex interaction between the innate and adaptive immune system. T cells interact with dendritic cells, macrophages, and keratinocytes, which can be mediated by their secreted cytokines. In the past decade, biologics targeting tumor necrosis factor-α, interleukin (IL)-23, and IL-17 have been developed and approved for the treatment of psoriasis. These biologics have dramatically changed the treatment and management of psoriasis. In contrast, various triggering factors can elicit the disease in genetically predisposed individuals. Recent studies suggest that the exacerbation of psoriasis can lead to systemic inflammation and cardiovascular comorbidity. In addition, psoriasis may be associated with other auto-inflammatory and auto-immune diseases. In this review, we summarize the risk factors, which can be divided into two groups (namely, extrinsic and intrinsic risk factors), responsible for the onset and exacerbation of psoriasis in order to facilitate its prevention.

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“…There are many literature reports on the long-term persistence of lesions in post-operative scar, smallpox and postvaccination (BCG) scars, and stretch marks [80,85]. Even low-intensity stimuli can provoke psoriatic lesions: for example, electrocardiography or wearing jewelry [89,90].…”

Section: Mechanical Traumamentioning

confidence: 99%

The impact of external factors on psoriasis

Owczarczyk‐Saczonek

Kasprowicz-Furmańczyk

Krajewska–Włodarczyk

et al. 2022

Postępy Higieny I Medycyny Doświadczalnej

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Psoriasis is one of the most common chronic inflammatory skin diseases, constituting a significant health and socioeconomic problem. Despite numerous therapeutic options, the results of treatment very often remain insufficient. It is extremely important to remember that many external factors impact the effectiveness of therapy. This article discusses the importance of emollients in therapy and the influence of infectious agents and injuries on the course of psoriasis. Understanding the above-mentioned factors in the treatment of psoriasis is critical to achieve satisfactory therapeutic effects.

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ECG-Induced Koebner Phenomenon

Cited by 7 publications

References 0 publications

Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms

Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms

Risk Factors for the Development of Psoriasis

The impact of external factors on psoriasis

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