ECG diagnosis of MI in LBBB

Spodick, David H.

doi:10.1016/0002-8703(89)90453-5

Cited by 3 publications

(4 citation statements)

References 2 publications

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“…In contrast, Zhao et al42 found only a 10% reduction of DNA methylation in various tissues after abolishment of the association between H3K9me2/3 and UHRF1 in mammals, indicating that H3K9 methylation binding of UHRF1 is not the only process to ensure DNA methylation. A positive correlation exists between UHRF1 and EZH2 in cancer cells,43,44 and EZH2 participates in H3K27 methylation which mediates gene silencing 45,46. Ferry et al47 found nonhistone mammalian DNA ligase 1 (LIG1), which contains a conserved H3K9-like mimic can also be methylated by G9a/GLP at K126 and subsequently recruit UHRF1 to replication foci, which is similar to binding H3K9me2/3 to maintain DNA methylation.…”

Section: Uhrf1 Allows Crosstalk Between Dna Methylation and Histone Cmentioning

confidence: 99%

Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies

Xue

Zhao

Feng

et al. 2019

OTT

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Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) functions as an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tatinteractive protein by multiple corresponding domains of DNA and H3 to maintain DNA methylation and histone modifications. Overexpression of UHRF1 has been found as a potential biomarker in various cancers resulting in either DNA hypermethylation or global DNA hypomethylation, which participates in the occurrence, progression, and invasion of cancer. The role of UHRF1 in the reciprocal interaction between DNA methylation and histone modifications, the dynamic structural transformation of UHRF1 protein within epigenetic code replication machinery in epigenetic regulations, as well as modifications during cell cycle and chemotherapy targeting UHRF1 are evaluated in this study.

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Section: Uhrf1 Allows Crosstalk Between Dna Methylation and Histone Cmentioning

confidence: 99%

Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies

Xue

Zhao

Feng

et al. 2019

OTT

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“…The diagnosis of previous MI in the presence of LBBB, fascicular block, Wolf-Parkinson-White syndrome or right ventricular pacing is challenging and despite several criteria have been proposed, the real diagnostic value of these criteria remains controversial [8][9][10][11]. From these criteria five of them have been studied commonly but results of these studies are controversial and most of them are rather old [6][7][8][9][10][11]. Kochiadakis et al [6] evaluated five criteria for determining previous Abbreviation: ODA -overall diagnostic accuracy.…”

Section: Discussionmentioning

confidence: 99%

Pace-Ecg in Previous Myocardial Infarction: An Unfinished Story

et al. 2014

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Aim. The diagnosis of previous myocardial infarction (MI) is difficult in patients with pacemaker and usually further tests must be done to confirm the diagnosis. To overcome this difficulty five major ECG criteria have been proposed by authors: 1. Notching 0.04 second in the ascending limb of the S wave of leads V3,4 or 5 (Cabrera's sign), 2. Notching of the upstroke of the R wave in leads I, aVL or V6 (Chapman's sign), 3. Q wave >0.03 second in leads I, aVL or V6, 4. Notching of the first 0.04 second of the QRS complex in leads II, III, aVF, 5. Q wave >0.03 second in leads II, III, aVF. The aim of this study is to find the predictive value of the five major proposed criteria for MI in pacing ECG of patients with previous MI. Material and methods. Twenty-three pacemaker patients with known MI (anterior 15, inferior 8) and 24 healthy pacemaker control patients; 17 female, 30 males, aged between 17-92 years with mean age of 59,5 ± 20 years, total 47 patients were studied. Documentation and localization of MI was based on history and confirmed by angiography and or scintigraphy. Results. Sensitivity was lower in all parameters for prediction of any MI whereas specificity was higher and ODA was moderate. Cabrera's and Chapman's sign had moderate sensitivity (60%-60%) whereas high specificity (90%-90%) and ODA (81%-81%) for anterior MI. Sensitivity of Q wave in I, aVL or V6 was lower (47%) for anterior MI but specificity and ODA was higher 84% and 92% respectively. Conclusion.In conclusion Cabrera's and Chapman's sign have a moderate sensitivity and higher specificity for recognising previous anterior MI in pacing patients. Цель. Диагностика перенесенного инфаркта миокарда (ИМ) является трудной у пациентов с кардиостимулятором и, как правило, дальнейшие исследования должны быть проведены, чтобы подтвердить диагноз. Чтобы преодолеть эту трудность, авторами предложены пять основных ЭКГ-параметров: 1. Зубец 0.04 второй восходящей ветви волны S в отведениях V 3, 4 или 5 (признак Cabrera), 2. Зубец восходящей R-волны в отведениях I, aVL или V6 (признак Chapman), 3. Волна зубца Q >0.03 секунды в отведениях I, aVL или V6, 4. Зубец в первые 0.04 секунды комплекса QRS в отведениях II, III, aVF, 5. Волна зубца Q >0.03 секунды в отведениях II, III, aVF. Целью данного исследования является поиск прогностической ценности из пяти основных предложенных критериев для ИМ при пейс-ЭКГ у пациентов с перенесенным ИМ. Материал и методы. Двадцать три пациента с кардиостимуляторами с известным ИМ в анамнезе (передне-стеночный 15, заднее-стеночный 8) и 24 здоровых пациента с кардиостимуляторами контрольной группы; 17 женщин, 30 мужчин в возрасте от 17-92 лет, средний возраст 59,5 лет, всего 47 больных были изучены. Документация и локализация ИМ были основаны на истории болезни и подтверждены ангиографией или сцинтиграфией. Результаты. Чувствительность была ниже во всех параметрах для прогнози-рования ИМ любой локализации, принимая во внимание, что специфичность была выше и общая диагностическая точность (ОДТ) была умеренной. При-знаки Cabr...

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“…However, the real diagnostic value of these criteria remains controversial. [1][2][3][4][5][6][7][8] The discrepancies in findings are due in part to the limitation of the different methods used to confirm underlying MI in these patients. Such limitations include the use of incomplete or inaccurate clinical histories, the selection bias of necropsy studies for older and sicker patients, false-positive results of 201 Tl scintigraphy, particularly in these patients, the difficulties of interpreting left ventricular wall motion, already abnormal in these patients, and the restriction to chronic Q wave MI with retrospective ECG analysis.…”

Section: Discussionmentioning

confidence: 99%

“…lack of control groups and by the use of ECG interpretation not "blinded" to the presence of MI. [1][2][3][4][5][6][7][8][9] To avoid many of the above-mentioned limitations, this study was designed where patients with known MI were paced temporarily to evaluate five of the major proposed criteria for the diagnosis of MI on the paced ECG. In this way, not only were the authors certain that the patients had a Q wave infarction, but they were also able to precisely determine the location and the extent of the infarct.…”

Section: Discussionmentioning

confidence: 99%

Electrocardiographic Appearance of Old Myocardial Infarction in Paced Patients

Kochiadakis

Kaleboubas

Igoumenidis

et al. 2002

Pacing Clinical Electrophis

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This study evaluated the possibility of diagnosing chronic myocardial infarction in the presence of the pacing electrocardiogram. Forty-five patients with known myocardial infarction (anterior 23, inferior 22) and 26 healthy controls were studied. After coronary angiography, pacing was applied from the right ventricular apex, and the sensitivity, specificity, and average diagnostic accuracy of five criteria on the paced electrocardiogram were assessed: (1) Notching 0.04 second in duration in the ascending limb of the S wave of leads V3, V4, or V5 (Cabrera's sign); (2) Notching of the upstroke of the R wave in leads I, aVL, or V6 (Chapman's sign); (3) Q waves > 0.03 second in duration in leads I, aVL, or V6; (4) Notching of the first 0.04 second of the QRS complex in leads II, III, and aVF; (5) Q wave > 0.03 second in duration in leads II, III, and aVF. The most sensitive criteria, for anterior and inferior myocardial infarctions were Cabrera's and Chapman's (91.1 and 86.6%, respectively). All criteria had low specificity (range 42.3-69.2%). The combination of Cabrera's and Chapman's sign decreased the sensitivity to 77.7%, but increased specificity to 82.2%. The sensitivity and specificity of all the criteria were independent of the myocardial infarction site. In paced patients, the application of electrocardiographic criteria, and especially the combination of Cabrera and Chapman, provides useful clinical information in recognizing prior myocardial infarction but not in assigning the specific infarct site.

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ECG diagnosis of MI in LBBB

Cited by 3 publications

References 2 publications

Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies

Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies

Pace-Ecg in Previous Myocardial Infarction: An Unfinished Story

Electrocardiographic Appearance of Old Myocardial Infarction in Paced Patients

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