ECG Abnormalities in Polymyositis

Stern, Richard

doi:10.1001/archinte.1984.04400020097015

Cited by 77 publications

(30 citation statements)

References 29 publications

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“…Our study population is quite small and a larger patient number would be needed to refine our results. Identification of autoimmune myocardial involvement is difficult because of nonspecific ECG signs 23,37 , subclinical echocardiographic abnormalities 38 , and nonspecific laboratory results (elevated cTnT, CK) 39 . As mentioned, cardiac MRI could help diagnosis with recognition of acute myocarditis 40 .…”

Section: Journal Of Rheumatologymentioning

confidence: 99%

Echocardiographic Abnormalities in New-onset Polymyositis/dermatomyositis

Peter

Balogh²,

Szilágyi³

et al. 2014

J Rheumatol

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Section: Journal Of Rheumatologymentioning

confidence: 99%

Echocardiographic Abnormalities in New-onset Polymyositis/dermatomyositis

Peter

Balogh²,

Szilágyi³

et al. 2014

J Rheumatol

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“…Although Kehoe et al argued the extent of conduction system disease may be related to the severity of skeletal muscle involvement, 10 several other studies showed that there was no correlation of overall severity of the disease with the presence of pathologic cardiac involvement. 11,12 Bohan A et al found that cardiac abnormalities were more frequent in patients with PM than in patients with DM. 4 In addition, Wilhelmina et al demonstrated antibody (anti-Ro) is a marker for cardiac injury in PM/DM.…”

Section: Incidence and Risk Factor Of Cardiac Involvementmentioning

confidence: 99%

“…11,16,25 Besides immunosuppressive therapy, traditional heart medications such as nitrates, β-blockers, and calcium antagonists diuretics are also of benefit to patients. There are a few reports of patients with AV block who have been successfully treated with pacemakers.…”

Section: Treatmentmentioning

confidence: 99%

Cardiac Involvement in Adult Polymyositis or Dermatomyositis: A Systematic Review

Wang

et al. 2012

Clinical Cardiology

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Background: To investigate the clinical features of cardiac involvement in polymyositis (PM) or dermatomyositis (DM). Hypothesis: More attention will be focused on the heart in PM/DM as we would have wished, which contribute to improve the prognosis. Methods: All articles published in English were retrieved by searching MEDLINE via PubMed (1975-2011. After selecting eligible articles according to the predefined inclusion and exclusion criteria, a systemic review was carried out. Results: A total of 26 articles were included in this study, which included 1530 patients. The incidence of cardiac involvement was 9% to 72%. Heart failure was the most frequent (32% to 77%) clinical symptom. Among the abnormal electrocardiogram and ultrasonic cardiogram, the incidence of conduction abnormalities, left ventricular diastolic dysfunction, and hyperkinetic left ventricular contraction were 25% to 38.5%, 42%, and 6% to 12%, respectively. The pathologic findings revealed myocardial inflammation, degenerative changes and necrosis similar to that in skeletal muscles. Cardiac manifestations of some patients improved after glucocorticoid and immunosuppressant treatment. Thirty-seven patients (46.3%) died as a direct result of heart disease. Conclusions: Heart abnormalities are frequent in patients with PM/DM, most of which were subclinical. The efficacy of glucocorticoids and immunosuppressants is uncertain. Cardiac involvement is a common cause of death.

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“…Despite the extremely signifi cant differences in activities of creatine kinase (CK) (p < 0.0001), lactate dehydrogenase (LDH) (p < 0.0001) and aldolase (ALD) (p < 0.0001) between the study and the control group (Table 3), we did not observe elevated activities of these enzymes among the examined patients with intraventricular conduction disturbances in ECG. Therefore no correlation between activity of these enzymes and involvement of autonomic nervous system or conduction system was demonstrated [9].…”

Section: Discussionmentioning

confidence: 97%