Ecdysteroids reverse resistance of human mdr1 gene transfected mouse lymphoma cells

Investigation of plants containing unusual ecdysteroids with ring in their side-chain

“…51 Recent experiments demonstrated that certain ecdysteroids possess a strong MDR-reversal effect, which could be of therapeutic significance. 52,53 Among the ecdysteroids involved in those experiments, those which were more apolar seemed to be the more effective. The strong activity of some ecdysteroids in modulating of multi-drug resistance of a cancer cell line has given a new perspective to ecdysteroid research; further studies are needed to elucidate the mechanisms of the MDR-reversal effects.…”