Ecdysteroids from leaves of <i>Vitex trifolia</i>

Thoa, Nguyen Thi Kim; Ban, Ninh Khac; Trang, Đỗ Thị; Linh, Trần Mỹ; Giang, Vu Huong; Nhiệm, Nguyễn Xuân; Kiệm, Phan Văn

doi:10.1002/vjch.201800006

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Within the various Vitex species, ecdysteroids are of great attention due to their distinctive characteristics advantageous in chemotaxonomy ( Sena Filho et al, 2008 ). Noteworthy ecdysteroids, such as ecdysone (compound 120 ), 20-hydroxyecdysone (compound 121 ), 20-hydroxyecdysone 2,3-monoacetonide (compound 122 ), turkesterone (compound 123 ), and polypodine B (compound 124 ), have been identified in the leaves of this plant ( Thoa et al, 2018 ). Additionally, this species is known to contain several sterol derivatives—specifically phytosterols (compounds 112–118 ) and an ergostanoid (compound 119 )—which have been reported to contribute to the phytochemical diversity of the plant ( Huang et al, 2013 ; Ban et al, 2018 ; Li et al, 2020b ).…”

Section: Biosynthesis Of Terpenoids Flavonoids and Iridoidsmentioning

confidence: 99%

A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.

Mottaghipisheh,

Kamali,

Doustimotlagh

et al. 2024

Front. Pharmacol.

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Plants, renowned for their rich reservoir of metabolites, play a pivotal role in addressing health-related issues. The Verbenaceae family stands out, showcasing immense potential in preventing and treating chronic diseases. Vitex trifolia L. (V. trifolia), a shrub with a rich history in traditional medicine, particularly in Eastern Asia, has garnered attention for its diverse therapeutic applications. This comprehensive review aims to bridge traditional knowledge and contemporary insights by investigating ethnopharmacology, phytochemistry, and pharmacological effects of V. trifolia. The keyword “V. trifolia” and its synonyms were searched within the main scientific databases including PubMed, Web of Science, ScienceDirect, Google Scholar, and Baidu Scholar (from 1974 to 2022, last search: 21.10.2023). Phytochemical analyses reveal a spectrum of secondary metabolites in V. trifolia, including terpenoids, flavonoids, lignans, phytosterols, anthraquinones, and fatty acids. Notably, terpenoids and flavonoids emerge as the main bioactive metabolites. Pharmacological studies validate its therapeutic potential, demonstrating significant antioxidant, anti-inflammatory, hepatoprotective, anticancer, anti-amnesic, antimicrobial, antiviral, anti-malaria, antispasmodic activities, and reported insecticidal effects. Despite existing literature exploring pharmacological attributes and secondary metabolites of related species, a conspicuous gap exists, specifically focusing on the pharmacological activities and novel methods of purification of pure metabolites from V. trifolia. This review aimed to fill this gap by delving into traditional medicinal applications, exploring secondary metabolites comprehensively, and providing an in-depth analysis of pharmacological effects of pure metabolites. Combining traditional uses with contemporary pharmacological insights, this article sought to serve as a crucial reference for future research and practical application of V. trifolia. This approach contributes substantially to understanding the plant, fostering scientific inquiry, and facilitating its broader application in healthcare.

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Section: Biosynthesis Of Terpenoids Flavonoids and Iridoidsmentioning

confidence: 99%

A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.

Mottaghipisheh,

Kamali,

Doustimotlagh

et al. 2024

Front. Pharmacol.

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Phytotoxic potential of Vitex pseudo-negundo leaf and flower extracts and analysis of phenolic compounds

Haghighi

Saharkhiz

2021

Biocatalysis and Agricultural Biotechnology

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Two new alkaloids from the roots of Cocculus hirsutus (L.) W. Theob

Shivani,

Kumari,

Singh

et al. 2024

Natural Product Research

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Two undescribed alkaloids, 15-carboxydihydroerysotrine (1) and (14R)-4-methoxy-13,14-dihydrooxypalmatine (2), along with six known compounds, 1,6-didehydro-3,15,16-trimethoxy-9-methylerythrinanium (3), 8-oxytetrahydropalmatine (4), 20hydroxyecdysone (5), makisterone A ( 6) turkesterone ( 7) and magnoflorine (8) were isolated from the root part of Cocculus hirsutus (L.) W. Theob. Their structures were established based on detailed analysis of NMR, UV-Vis, HRESIMS, and single-crystal XRD spectroscopic experiments. Compounds 3, 4 and 7 were reported for the first time from the genus Cocculus. All the compounds were analysed in silico to investigate their human acetylcholinesterase inhibition potential. This analysis revealed that compounds 1 and 8 interacted well with the selected protein, which suggested their further exploration as acetylcholinesterase inhibitors via in vitro and in vivo investigation.

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Ecdysteroids from leaves of Vitex trifolia

Cited by 4 publications

References 10 publications

A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.

A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.

Phytotoxic potential of Vitex pseudo-negundo leaf and flower extracts and analysis of phenolic compounds

Two new alkaloids from the roots of Cocculus hirsutus (L.) W. Theob

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