Ecdysteroids and related compounds in fungi

Ковганко, Н. В.

doi:10.1007/bf02236282

Cited by 16 publications

(10 citation statements)

References 45 publications

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“…Phytoecdysteroids are analogues of the arthropod steroid hormones ecdysteroids, which regulate moulting and metamorphosis and have also been implicated in the regulation of reproduction, embryogenesis, and diapause. Ecdysteroids are also present in certain fungi (''mycoecdysteroids''; Kovganko, 1999;Sun and Yasukawa, 2008), but it is not clear if fungi generate these de novo or take up and modify phytoecdysteroids from the substratum. Ecdysteroid-like compounds occur in algae too (Fukuzawa et al, 1981(Fukuzawa et al, , 1986.…”

Section: Phytoecdysteroidsmentioning

confidence: 99%

The Karlson Lecture. Phytoecdysteroids: What use are they?

Dinan

2009

Arch Insect Biochem Physiol

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Phytoecdysteroids are analogues of arthropod steroid hormones found in plants, where they deter predation by non-adapted predators. There is potential to exploit this to develop new strategies for pest control, either by using ecdysteroids as lead molecules for the design of novel pest control agents or by alteration of ecdysteroid levels/profiles in crop plants through plant breeding or genetic modification. However, it is other properties of phytoecdysteroids that have led to a rapid recent increase in scientific and commercial interest in these molecules. They are apparently non-toxic to mammals and a wide range of beneficial pharmacological (adaptogenic, anabolic, anti-diabetic, hepatoprotective, immunoprotective, wound-healing, and perhaps even anti-tumour) activities is claimed for them. In particular, this has led to a large (and unregulated) market for ecdysteroid-containing preparations for body-builders, sportsmen, and pets, among others. Ecdysteroids are also being considered as nutraceutical additives to food products. Further, ecdysteroids are good candidates as elicitors for gene-switch systems to be used in medical gene therapy and research applications. In this article, I review the applications of phytoecdysteroids and assess their future potential.

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Section: Phytoecdysteroidsmentioning

confidence: 99%

The Karlson Lecture. Phytoecdysteroids: What use are they?

Dinan

2009

Arch Insect Biochem Physiol

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“…Kreisel (as Lasiosphaera fenzlii Reichardt), C. craniiformis and C. gigantea. The pharmaceutical relevance of these substances, most of which were reviewed also by Kovganko (1999), has yet to be established, however.…”

Section: Gigantea C Utriformis C Craniiformis and C Cyathi-mentioning

confidence: 99%

The genus Calvatia (Gasteromycetes, Lycoperdaceae): A review of its ethnomycology and biotechnological potential

Coetzee¹,

Wyk²

2009

Afr. J. Biotechnol.

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Several members of the fungal puffball genus Calvatia Fr. have found widespread use amongst various cultures world-wide, especially as sources of food and/or traditional medicine. Hitherto the biotechnological potential of only a handful of Calvatia species, namely C. cyathiformis, C. craniiformis, C. excipuliformis, C. gigantea and C. utriformis has been investigated. However, despite promising results, information regarding the biotechnological potential of the rest of the genus, in particular the African species, is still completely lacking. In the hope that it might stimulate interest and further research on this topic, the current paper provides a brief overview of the literature pertaining to the importance of Calvatia to man in terms of its pathogenicity, its ecology and role as bioindicator, its food and nutritional value and also its potential as biotechnological tool in the pharmaceutical and other industries.

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“…These compounds are not only present in insects, but can be found in much larger quantities in several terrestrial plant genera like Leuzea and Serratula [2,3]. Though ecdysteroids are also present in certain fungi and algae, their most important source is considered to be plants, where their concentration can reach as much as 1,000-fold higher than that typically found in arthropods [4,5,6]. Phytoecdysteroids can be found in all parts of plants: they are located in roots, rhizomes, seeds, bark, flowers and fruits [2].…”

Section: Occurrence and Structural Diversity Of Ecdysteroidsmentioning

confidence: 99%

“…NaIO 4 , Jones reagent or KMnO 4 ) proved to give a complex mixture of reaction products in our experiments, we turned our attention to [bis(trifluoroacetoxy)iodo]benzene (PIFA), a hypervalent iodine compound as reagent instead. A relatively large scale reaction was carried out: 2.0 g of 20E (1) was dissolved in methanol, 1.5 equivalent of PIFA was added, and the reaction mixture was stirred for an hour, before terminating the reaction and working it up as described in chapter 2.2.6.…”

Section: Preparation Of Side-chain Cleaved Ecdysteroidsmentioning

confidence: 99%

“…In vitro, side-chain cleavage requires a more potent oxidizing agent than molecular oxygen (used for autoxidation, described in the previous chapter), therefore common oxidizing agents -such as NaIO 4 , Jones reagent and KMnO 4 -were put to the test. However, these reagents proved to give a complex mixture of reaction products in our experiments, hence we used a hypervalent iodine compound (PIFA) instead as reagent, which showed to provide good yields of the desired reaction products (see chapter 2.2.6.…”

Section: Side-chain Cleavagementioning

confidence: 99%

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Preparation of novel bioactive semi-synthetic ecdysteroid derivatives

József¹

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Ecdysteroids and related compounds in fungi

Cited by 16 publications

References 45 publications

The Karlson Lecture. Phytoecdysteroids: What use are they?

The Karlson Lecture. Phytoecdysteroids: What use are they?

The genus Calvatia (Gasteromycetes, Lycoperdaceae): A review of its ethnomycology and biotechnological potential

Preparation of novel bioactive semi-synthetic ecdysteroid derivatives

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