2009
DOI: 10.1073/pnas.0810213106
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Ecdysone signaling regulates the formation of long-term courtship memory in adult Drosophila melanogaster

Abstract: Improved survival is likely linked to the ability to generate stable memories of significant experiences. Considerable evidence in humans and mammalian model animals shows that steroid hormones, which are released in response to emotionally arousing experiences, have an important role in the consolidation of memories of such events. In insects, ecdysone is the major steroid hormone, and it is well characterized with respect to its essential role in coordinating developmental transitions such as larval molting … Show more

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Cited by 121 publications
(136 citation statements)
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References 56 publications
(59 reference statements)
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“…32). Intriguingly, evolution of binding sites for CREB, a TF regulator of long-term memory (CREBB, Ishimoto et al 2009) and secretory activity (CREBA, Abrams and Andrew 2005) in insects, affects the most genes in this analysis (n = 31). This suggests that ants may have preferentially altered the binding distribution of CREB as a possible means to achieve gene expression plasticity between specialized castes (see below).…”
Section: Conserved Mirnas and Small Noncoding Rnas Exhibit Caste Diffmentioning
confidence: 99%
“…32). Intriguingly, evolution of binding sites for CREB, a TF regulator of long-term memory (CREBB, Ishimoto et al 2009) and secretory activity (CREBA, Abrams and Andrew 2005) in insects, affects the most genes in this analysis (n = 31). This suggests that ants may have preferentially altered the binding distribution of CREB as a possible means to achieve gene expression plasticity between specialized castes (see below).…”
Section: Conserved Mirnas and Small Noncoding Rnas Exhibit Caste Diffmentioning
confidence: 99%
“…Immunohistochemical detection showed that EcR was widely expressed in the adult brain 44 . EcR-mediated signalling in adult flies has an important role in the formation of long-term memory) and sleep regulation 44,45 , and defective long-term memory and sleep in EcR mutants is thought to be caused by insufficient EcR-mediated signalling.…”
Section: Abnormal (N =4)mentioning
confidence: 99%
“…Immunohistochemical detection showed that EcR was widely expressed in the adult brain 44 . EcR-mediated signalling in adult flies has an important role in the formation of long-term memory) and sleep regulation 44,45 , and defective long-term memory and sleep in EcR mutants is thought to be caused by insufficient EcR-mediated signalling. Previous studies showed that deletion of EcREs in the pri-let-7-C locus caused a reduction and delay of let-7-C miRNA expression in adult flies and is associated with a let-7-C mutant phenotype 37 .…”
Section: Abnormal (N =4)mentioning
confidence: 99%
“…The EIA has been used to detect ecdysteroids in Drosophila melanogaster (e.g., Ishimoto et al 2009;Yamanaka et al 2015) and allows determination of hemolymph titers in individual worker honey bees with commercially available reagents. The polyclonal rabbit IgG antibody on which this EIA is based was raised against 20E (No.…”
Section: Enzyme Immunoassay Of Ecdysteroidsmentioning
confidence: 99%