Eccrine syringofibroadenoma (Mascaro)

Circumscribed acral hypokeratosis

“…Eccrine syringofibroadenoma has, historically, been described as a solitary lesion (putatively hamartomatous or, possibly, neoplastic), 13,14 as nevoid lesions sometimes presenting in linear patterns, 15 and as hyperplasias (eg, in scar sites, regressed keratoacanthoma fields, and some areas of vascular compromise, and rarely in patients with ectodermal dysplasias). 16,17 It is not fully clear why this association is present in case 2.…”

Eccrine Syringofibroadenoma: Report of a Case and Analysis of Cytokeratin Expression

“…Approximately 30 cases have been reported in the literature. Mehregan et al [9] and Mehregan [10] designated ESFA as an acrosyringeal adenoma, a true neoplasm. Hashimoto et al [11] considered ESFA as a subtype or variant of eccrine poroma or eccrine spiradenoma.…”

“…The nosology of ESFA is still controversial. There is a trend that a single lesion is diagnosed as an adenoma [9, 10], and multiple lesions in a symmetrical or linear distribution are diagnosed as nevoid lesions [12, 13]. Multiple lesions occasionally develop in a patient with hydrotic ectodermal dysplasia, and these are considered as a variant of nevoid lesion [14, 15, 16].…”

“…Mehregan et al [9] and Kanitakis et al [21] studied ESFA immunohistochemically and suggested its acrosyringeal differentiation. The results of these studies, however, are insufficient to prove the acrosyringeal differentiation [22].…”

Eccrine Syringofibroadenomatous Hyperplasia in a Patient with Bullous Pemphigoid: A Case Report and Review of the Literature

“…Cases 3, 5, 12 and 13 were reported as eccrine poroma, and case 4 was reported as acrosyringeal nevus. Mehregan et al [7], however, pointed out that the cases 3 and 4 should be clas sified as ESFA because the histologic appearance of cases 3 and 4 was a proliferation of acrosyringeal epithelium in a sponge-like mass filled with a well-organized fibrovascular stroma and this feature was considered to be an adenoma, not an adnexal nevus. We also consider the cases 5, 12 and 13 as ESFA rather than eccrine poroma.…”