Eccrine sweat gland regeneration: still a story of ‘blood, toil, tears and sweat’

Pontiggia, Luca

doi:10.1111/bjd.15564

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…It is conceivable that the common microenvironment that ESGs, HFs and dWAT share represents a niche that is of major importance for skin regeneration, which complements the known regenerative functions of the HF connective tissue sheath and its progenitor cell population . The regenerative capacity of epithelial cells from the ESG secretory coil is well known, and ESGs are major players in the re‐epithelialization of human wounds . Moreover, label‐retaining epithelial progenitor cells in ESGs have features in common with HF epithelial stem cells expressing keratin 15, and ESG epithelial cells can not only regenerate the ESG itself but can also undergo differentiation into epidermal keratinocytes so as to reconstruct an epidermis‐like structure in vitro …”

Section: Discussionmentioning

confidence: 99%

Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue

et al. 2018

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We propose a model of functional human skin anatomy in which ESGs are closely associated with the PSU and the dWAT to form a common homeostatic tissue environment, which may best be encapsulated in the term 'adnexal skin unit'. The challenge now is to dissect how each component of this superstructure of human skin functionally cooperates with and influences the other under physiological conditions, during regeneration and repair and in selected skin diseases.

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Section: Discussionmentioning

confidence: 99%

Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue

et al. 2018

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An efficient method for eccrine gland isolation from human scalp

Jiménez

Alam

Hernández³

et al. 2018

Experimental Dermatology

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We describe a simple and efficient method to isolate eccrine sweat glands from the human scalp. This method is inspired by the hair graft harvesting method used in hair transplantation. Based on the recently described anatomical relationship between the scalp hair follicle and the eccrine gland, we have found that scalp follicular unit grafts are an excellent eccrine gland isolation source, especially for the coiled component. In order to make the gland visible for stereoscopic microdissection, the follicular units need to be previously stained with a vital dye like methylene blue or neutral red. The simplicity and efficiency of this isolation method should encourage further research into human eccrine sweat gland function which has always been hindered by the difficulty of gland isolation.

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Eccrine sweat gland regeneration: still a story of ‘blood, toil, tears and sweat’

Abstract: Linked Article: Borowczyk‐Michalowska et al. Br J Dermatol 2017; 176:1541–1548.

Cited by 2 publications

References 8 publications

Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue

Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue

An efficient method for eccrine gland isolation from human scalp

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