Eccrine Porocarcinoma

Abstract

The histological, electron microscopic, and immunological findings in a case of eccrine porocarcinoma are described. The tumors were verrucous, wart‐like lesions and nodules which ulcerated secondarily. They were located on the leg. The patient died in a few months from dissemination of the disease. The tumor examined was epidermotropic and mainly composed of a clear cell proliferation. Ultrastructurally, the cells showed large, nucleolated nuclei, numerous mitochondria, dilated endoplasmic reticulum, single desmosomal plaques, sparse tonofibrils in the perinuclear region, multivesicular dense bodies, and interdigitating cytomembranes. A few dark cells were present. No Langerhans cells, indeterminate dendritic cells or melanocytes were observed. The tumor cells were labeled with KL 1 monoclonal antikeratin antibody. The secretory cells of uninvolved eccrine sweat glands in the close vicinity of the tumor and in the perilesional skin were strongly labeled with D 47 monoclonal antibody reacting with the secretory cells of human eccrine sweat gland, whereas the tumor cells remained unlabeled. Our study results showed that the origin of this tumor was not the secretory portion of the gland but rather its excretory portion.

NUT Is a Specific Immunohistochemical Marker for the Diagnosis of YAP1-NUTM1-rearranged Cutaneous Poroid Neoplasms

“…In this context, several immunohistochemical markers have been proposed to distinguish benign and malignant poroid tumors from their differential diagnoses. Indeed, epithelial membrane antigen is expressed in poroma cells, and carcinoembryonic antigen highlights the ductal structures 8–10. In addition, several other markers have been described with variable diagnostic performance 10…”

“…Indeed, epithelial membrane antigen is expressed in poroma cells, and carcinoembryonic antigen highlights the ductal structures. [8][9][10] In addition, several other markers have been described with variable diagnostic performance. 10 Recently, Sekine et al 11 have reported recurrent YAP1-MAML2 and YAP1-NUTM1 fusion transcripts in poroma and porocarcinoma.…”

Eccrine porocarcinoma on the cheek

“…Recent studies have performed immunohistochemical staining using carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), and S-100 protein. CEA and EMA were positive in the intraepidermal ductal cell, and S-100 protein was negative [8]. Histologically, when the tumor cells are localized within the epidermis, it is necessary to differentiate from hidroacanthoma simplex, Bowen’s disease, seborrheic keratosis among others.…”

Porocarcinoma ecrino metastásico

“…Nuestro caso presentó tumoración con patrón infiltrante a dermis, células redondas pleomorficas, atipia nuclear, que conformaban estructuras lobulares y en nidos con 12 mitosis x campo de alta potencia, e infiltración vascular y linfática. Existen casos que requieren otras tinciones para su diferenciación, para lo cual se solicitan estudios inmunohistoquímicos con expresión de citoqueratinas, antígeno de membrana epitelial, y antígeno carcinoembrionario (13) . Según el estudio inmunohistoquímico nuestro caso fue positivo para las tinciones de citoqueratina AE1/AE3 y EMA; y negativos para las tinciones CEA, y citoqueratina 7.…”