Eccrine Porocarcinoma: Clinical and Pathological Report of Eight Cases

Abstract

Background: Eccrine porocarcinoma (EPC), a slow-growing carcinoma of the sweat gland, is a rare condition documented only in a small number of case series. Due to its rarity, guidelines and specific recommendations are not widely available. Accordingly, many dermatologists encounter difficulty in diagnosing and treating EPC. The aim of this study is to report the clinical and pathological features of EPC in order to contribute to the body of information currently available on the subject. Patients and Methods: From 2003 to 2013, 8 Japanese patients were diagnosed with EPC at the Department of Dermatology in the Hachioji Medical Center of Tokyo Medical University. Patient data, including clinical manifestations, histopathological findings, immunohistochemical results, treatment method, and clinical course were collected and documented. Results: The mean age of the patients (6 males and 2 females) was 72.6 years. The duration of the lesions ranged from 4 months to 5 years (mean: 3.5 years). All of the lesions clinically presented with erosive reddish nodules (mean size: 39.0 mm). Initial CT imaging revealed that 1 case had multiple distant metastases. Surgical resection was performed for all primary lesions and follow-up observations were available in all cases (mean: 10.9 months). One case with distal metastases underwent both radiation therapy and chemotherapy, but nevertheless succumbed to the disease. Conclusion: The EPC cases in our department presented a versatile clinical appearance and characteristic histopathological features.

Radioterapia en porocarcinoma ecrino: revisión de la literatura

“…El porocarcinoma ecrino cuenta con una escueta descripción de sus factores pronósticos. En general se sabe que alrededor del 20% de estos tumores presentarán recurrencia, el 20%, metástasis en ganglios linfáticos regionales, y el 10%, metástasis a distancia 12,13 . Como factores asociados al tumor está la presencia de tumoraciones primarias > 5 cm, como es el caso de nuestra paciente; se tiende a una mayor incidencia de enfermedad ganglionar regional, la cual no fue presentada en este caso.…”

Eccrine Porocarcinoma of the Scalp: A Case Report and Review of Literature

“…These lesions are composed of large, basaloid and atypical neoplastic cells with hyperchromatic nuclei and some mitotic figures. Duct-like structures with eosinophilic cuticular borders are constant findings [15]. On the other hand, immunohistochemical features like positivity for carcinoembryonic antigen or epithelial membrane antigen help to confirm the diagnosis of difficult cases where histopathological findings are not conclusive [4].…”

“…Gross total surgical excision with safety margin is the main stone of management of EPC with cure rate of 70-80% [9,15]. Lymph nodes dissection is to be considered in case of regional lymph node involvement [10].…”

Eccrine Porocarcinoma: A Case Report of a Rare Skin Malignancy (Dermatopathologic View)

“…They named it epidermotropic eccrine carcinoma. Since then, in literature there have been published numerous case reports [4][5][6][7][8][9][10][11]. Due to the rarity of this oncological entity, accurate data on its incidence, etiopathogenesis, and biological behaviour are quite poor.…”

“…The original study series have demonstrated local recurrences in 4.1-35% [4-7, 10, 11] and metastases in 4.1-50% of cases [4][5][6][7][8][9][10]. Despite marked percentage variance, these data suggest that EP is likely an aggressive and prognostically unfavorable type of cutaneous neoplasia.…”