Eccrine angiomatous hamartoma: Report of a case and literature review

Nakatsui, Thomas; Schloss, Eric; Krol, Alfons; Lin, Andrew N.

doi:10.1016/s0190-9622(99)70416-0

Cited by 48 publications

(54 citation statements)

References 26 publications

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“…Glomus-like neurovascular bodies, as reported for the related palmar cutaneous hamartoma, were not seen, but small nerves evident in the S-100 protein immunostain were an accompaniment [2]. Neither infiltration of periadnexal adipose tissue nor pilar structures were observed [4]. Our immunohistochemical studies showed strong reactivity of both secretory and ductal structures of eccrine glands for MNF116 (cytokeratins 5, 6, 8 and 17), but neither stained for cytokeratins 19 and 20.…”

Section: Histopathological Findingssupporting

confidence: 50%

“…In a recent case report reviewing the English literature, 23 other well-documented cases were found, and a few more examples came to record in the French literature [4, 8, 9]. Clinically, the condition presents most often as a solitary papule, nodule or plaque, but multiple variants have been observed [4, 5, 7, 10, 11].…”

Section: Discussionmentioning

confidence: 99%

“…Eccrine angiomatous hamartoma/nevus (EAH), initially described in 1968 by Hyman et al [3], is a rare example characterized histologically by enlarged secretory coils of eccrine sweat glands associated with vascular channels; optional findings include pilar structures and infiltration of adipose tissue [1, 3, 4, 5]. To the best of our knowledge, the immunohistochemical profile of EAH has remained incomplete, and imaging characteristics are still lacking [5, 6, 7].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Late-Onset Eccrine Angiomatous Hamartoma: Clinical, Histological and Imaging Findings

Laeng¹,

Heilbrunner²,

Itin³

2001

Dermatology

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Eccrine angiomatous hamartoma (EAH) is an exceedingly rare benign tumor-like lesion prevalent in childhood which may produce pain and marked sweating. Although an aggressive treatment is not generally indicated, surgery may be considered in severe cases. In this report we present novel morphological findings by immunophenotyping, document the first MRI findings in EAH and emphasize the importance of preoperative imaging of such lesions.

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Section: Histopathological Findingssupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Late-Onset Eccrine Angiomatous Hamartoma: Clinical, Histological and Imaging Findings

Laeng¹,

Heilbrunner²,

Itin³

2001

Dermatology

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“…[1][2][3][4] It usually arises at birth or during early infancy and childhood as a nodule or a plaque predominantly involving the distal extremities. Although some EAH cases are asymptomatic, pain and hyperhidrosis are common.…”

mentioning

confidence: 99%

“…8 EAH is a benign lesion and, as a rule, aggressive treatment is unnecessary if asymptomatic. 1,2,9 Associated pain and cosmesis are the most common reasons for treatment of EAH.…”

mentioning

confidence: 99%

Eccrine angiomatous hamartoma with sudden enlargement and pain in an adolescent girl after menarche

Kikusawa¹,

Oka²,

Taguchi

et al. 2011

Dermato-Endocrinology

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Eccrine angiomatous hamartoma (EAH) is a rare, benign cutaneous lesion characterized histologically by a proliferation of eccrine glands and vascular structures-generally capillaries-in the middle and deep dermis. Sudden enlargement of EAH lesions with or without pain has been noted during puberty and pregnancy and has been attributed to hormonal stimulation. We herein describe a case of EAH that became symptomatic in an adolescent girl. A 13-year-old girl presented with pain associated with a sudden enlargement of a previously asymptomatic swelling on her right second toe. She had an 8-year history of an asymptomatic swelling on her right second toe, and the symptoms appeared approximately 1 year after menarche. Physical examination revealed swelling of the plantar surface of her right second toe. The overlying surface was erythematous with a small amount of fine scales. The biopsied tissue showed a nodular proliferation of eccrine glands intimately admixed with numerous small vessels in the deep dermis and subcutaneous fat tissue. Mucin deposition was present in the stroma surrounding the proliferating eccrine coils and ducts and in the upper dermis. A diagnosis of EAH was made. We suggest that hormonal changes during puberty may have played a role in the rapid growth and pain in the present case.Eccrine angiomatous hamartoma (EAH) is a rare, benign cutaneous lesion characterized histologically by a proliferation of eccrine glands and vascular structures

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