Eccentric exercise-induced muscle weakness abolishes sex differences in fatigability during sustained submaximal isometric contractions

Jodoin, Hanna L.; Hinks, Avery; Roussel, Olivia P.; Contento, Vincenzo S.; Dalton, Brian H.; Power, Geoffrey A.

doi:10.1016/j.jshs.2023.02.001

Cited by 1 publication

(3 citation statements)

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“…Central command could have been augmented in the present study because of changes in fatigability or sensory feedback. EIMW has been shown to increase fatigability (46,47), although this has been an inconsistent finding (35). Interestingly, sex-based differences in performance fatigability also seem to be impacted by EIMW, such that female individuals lose their superior fatigue resistance over male individuals (47).…”

Section: Discussionmentioning

confidence: 99%

“…EIMW has been shown to increase fatigability (46,47), although this has been an inconsistent finding (35). Interestingly, sex-based differences in performance fatigability also seem to be impacted by EIMW, such that female individuals lose their superior fatigue resistance over male individuals (47). Increased fatigability could be due to increased perception of effort/altered sense of force after eccentric exercise (21).…”

Section: Discussionmentioning

confidence: 99%

“…We analyzed our data according to sex to expand upon prior observations that both sexes show a threshold level of strength that is associated with increased BP responsiveness compared with weaker counterparts (6). Because male participants experience larger absolute reductions in force production after eccentric exercise (47,60), we speculated that the reduction in BP responses during PECO in the full cohort could be driven primarily by reduced BP responses in male but not female participants. In contrast, we observed no significant sex-time interactions, or any main effects of sex.…”

Section: Discussionmentioning

confidence: 99%

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Blood Pressure Responses to Postexercise Circulatory Occlusion Are Attenuated After Exercise-Induced Muscle Weakness

Lee

Katerberg

Bommarito

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose Exercise blood pressure (BP) responses are thought to be determined by relative exercise intensity (percent maximal voluntary contraction (MVC) strength). However, cross-sectional studies report that during a static contraction, higher absolute force is associated with greater BP responses to relative intensity exercise and subsequent muscle metaboreflex activation with postexercise circulatory occlusion (PECO). We hypothesized that a bout of unaccustomed eccentric exercise would reduce knee extensor MVC and subsequently attenuate BP responses to PECO. Methods Continuous BP, heart rate, muscle oxygenation, and knee extensor electromyography were recorded in 21 young healthy individuals (female, n = 10) during 2 min of 20% MVC static knee extension exercise and 2 min of PECO, performed before and 24 h after 300 maximal knee extensor eccentric contractions to cause exercise-induced muscle weakness. As a control, 14 participants repeated the eccentric exercise 4 wks later to test whether BP responses were altered when exercise-induced muscle weakness was attenuated via the protective effects of the repeated bout effect. Results Eccentric exercise reduced MVC in all participants (144 ± 43 vs 110 ± 34 N·m, P < 0.0001). BP responses to matched relative intensity static exercise (lower absolute force) were unchanged after eccentric exercise (P > 0.99) but were attenuated during PECO (systolic BP: 18 ± 10 vs 12 ± 9 mm Hg, P = 0.02). Exercise-induced muscle weakness modulated the deoxygenated hemoglobin response to static exercise (64% ± 22% vs 46% ± 22%, P = 0.04). When repeated after 4 wks, exercise-induced weakness after eccentric exercise was attenuated (−21.6% ± 14.3% vs −9.3 ± 9.7, P = 0.0002) and BP responses to PECO were not different from control values (all, P > 0.96). Conclusions BP responses to muscle metaboreflex activation, but not exercise, are attenuated by exercise-induced muscle weakness, indicating a contribution of absolute exercise intensity on muscle metaboreflex activation.

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