Eccentric contractions of gastrocnemius muscle‐induced nerve damage in rats

Abstract

ECs with fast angular velocities induce functional and structural damage in innervating nerve.

Eccentric contraction–induced muscle damage in human flexor pollicis brevis is accompanied by impairment of motor nerve

“…We observed that ECCs of the FPBM resulted in significant delays in the MCV of the median nerve; that is, there was motor nerve dysfunction in human. This was consistent with the finding of an animal study in which a decrease in the MCV of the sciatic nerve observed after inducing ECCs in rat triceps muscles . Nerve damage is categorized as neuroplegic, axotomy, or neurite .…”

“…Because nerve is connected to skeletal muscles through the neuromuscular junction, it assumes that the motor and sensory nerve function may have the roles on muscle force production and muscle soreness. Previously, we showed that ECCs cause damage in nerves and skeletal muscle . Our results showed that ECCs resulted in a decrease in the muscle motor nerve conduction velocity (MCV) of the sciatic nerve as well as narrowing of its axons and myelin sheath .…”

“…As we mentioned above in muscle damage, neural dysfunction by ECCs would be apparent in elbow flexors. Otherwise, neuropraxia can be caused by mechanically induced injury, ischemia, inflammation, toxic compounds, and metabolic disorders . Colak et al attributed increases in M‐wave latency to muscle compartment pressure in the musculocutaneous nerve .…”

Repeated bouts of fast eccentric contraction produce sciatic nerve damage in rats

“…Recently, Lee et al examined the effects of a single bout of ECs on the sciatic nerve in a rat model of EC‐induced muscle damage. They used ECs with 2 different joint angular velocities (180°/s: fast and 30°/s: slow).…”

“…In the slow group, ECs did not induce any apparent sciatic nerve damage. They concluded that acute ECs with fast angular velocity induce transient damage not only in the muscle but also in the innervating nerve …”