Eccentric contraction induces inflammatory responses in rat skeletal muscle: role of tumor necrosis factor-α

Liao, Peng; Zhou, Jinping; Ji, Li Li; Zhang, Yong

doi:10.1152/ajpregu.00480.2009

Cited by 85 publications

(63 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The upregulation of TNF-␣ mRNA expression found in our study supports data from other investigations in rats (23) and humans (5), emphasizing the systemic proinflammatory response after eccentric exercise (31). However, TG presented a reduction in TNF-␣ mRNA abundance after the second bout, which would indicate that the eccentric training protocol mediated the downregulation of TNF-␣ mRNA levels.…”

Section: Discussionsupporting

confidence: 91%

Effects of eccentric exercise on toll-like receptor 4 signaling pathway in peripheral blood mononuclear cells

Fernandez‐Gonzalo

Paz

Rodriguez‐Miguelez

et al. 2012

Journal of Applied Physiology

View full text Add to dashboard Cite

Cuevas MJ, González-Gallego J. Effects of eccentric exercise on tolllike receptor 4 signaling pathway in peripheral blood mononuclear cells. J Appl Physiol 112: 2011-2018, 2012. First published March 29, 2012 doi:10.1152/japplphysiol.01499.2011This study aimed to investigate the response of the toll-like receptor 4 (TLR4) signaling pathway to an acute bout of eccentric exercise, and to assess whether eccentric training attenuated the effects induced by acute eccentric exercise. Twenty men (22.4 Ϯ 0.5 yr) were divided into a control group (CG, n ϭ 8) and a training group (TG, n ϭ 12). Both groups performed two acute eccentric bouts on a squat machine in a 9-wk interval. During this time, TG followed a 6-wk eccentric training program (3 session/wk; 3-5 sets of 10 repetitions with loads ranging between the 40 and 50% of maximal isometric voluntary contraction). CD14, TLR4, and TNF-␣ mRNA levels, and CD14, TLR4, myeloid differentiation factor 88, tumor necrosis factor receptor-associated factor 6, TIR-domain-containing adapterinducing interferon-␤, phospho-IB kinases, phospho-IB, phospho-ERK-1/2, and TNF-␣ protein concentration were measured in peripheral blood mononuclear cells, before, immediately, and 2 h after each eccentric bout. The first acute eccentric bout triggered a proinflammatory response mediated by an upregulation of all of the factors measured within the TLR4 signaling pathway. Following the training period and after the second acute bout, CG showed a similar proinflammatory response than that seen after the first bout. However, the eccentric training intervention decreased significantly the protein concentration of all factors analyzed in TG compared with results obtained after the first bout. These results suggest that the TLR4-signaling pathway plays a critical role in the proinflammatory response seen after acute eccentric exercise. This response was attenuated after an eccentric training program through myeloid differentiation factor 88-dependent and -independent pathways.

show abstract

Section: Discussionsupporting

confidence: 91%

Effects of eccentric exercise on toll-like receptor 4 signaling pathway in peripheral blood mononuclear cells

Fernandez‐Gonzalo

Paz

Rodriguez‐Miguelez

et al. 2012

Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

“…In addition, strenuous exercise can alter the inXammatory function and it has been related to the pathogeny of the muscular hurts and of the systemic inXammation (Tidball 2005;Gleeson 2007;Funes et al 2011). For these reasons, in this type of exercise is important to reduce both oxidative stress and the inXammatory response, at least theirs negative aspects (Liao et al 2010;Funes et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…In fact, a potential beneWcial eVect of exercise may be due to an IL-6-mediated reduction in TNF-expression and a concomitant avoidance of a low-grade inXammation state (Adser 2011). The reason of this beneWcial eVect is due to that TNF-seems to play an important role in the damage in skeletal muscle by the inXammation associated with strenuous exercise (Liao et al 2010). TNF-is a key citokyne promoting both peripheral muscle proteolysis and whole-body immune responses (Tidball 2005;Liao et al 2010).…”

Section: Discussionmentioning

confidence: 99%

“…The reason of this beneWcial eVect is due to that TNF-seems to play an important role in the damage in skeletal muscle by the inXammation associated with strenuous exercise (Liao et al 2010). TNF-is a key citokyne promoting both peripheral muscle proteolysis and whole-body immune responses (Tidball 2005;Liao et al 2010). This cytokine has been also shown to inhibit myogenesis and myocyte diVerentiation, and the absence of TNF-increases the rate of necrosis and regeneration in the early stages of the muscular damage (Tidball 2005;Liao et al 2010).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Phlebodium decumanum is a natural supplement that ameliorates the oxidative stress and inflammatory signalling induced by strenuous exercise in adult humans

et al. 2012

View full text Add to dashboard Cite

Strenuous exercise induces muscle damage due to a highly increased generation of free radicals and inflammatory response and therefore, in this type of exercise, it is important to reduce both oxidative stress and inflammation, at least their negative aspects. The purpose of this study was investigate, for the first time, whether a purified, standard water-soluble fraction obtained from Phlebodium decamanum could reduce the over-expression of inflammation and oxidative stress induced by strenuous exercise. The physical test consisted of a constant run that combined several degrees of high effort (mountain run and ultra-endurance), in permanent climbing. Biochemical parameters, oxidative stress and inflammatory mediators were assessed. The results showed that oral supplementation of P. decumanum during high-intensity exercise effectively reduces the degree of oxidative stress (decreased 8-hydroxy-2'-deoxyguanosine and isoprostanes generation, increased antioxidant enzyme activities in erythrocyte and total antioxidant status in plasma). The data obtained also indicate that this supplementation is efficient in reducing the inflammatory response through the decrease of TNF-α and increase of sTNF-RII, but kept the levels of IL-6 and IL-1ra. In conclusion, oral supplementation of P. decamanum extract during high-intensity exercise effectively reduces the degree of oxidative stress and has anti-inflammatory protective effects, preventing the over-expression of TNF-α but keeping the levels and effects of IL-6. These findings provide a basis for similar Phlebodium supplementation for both professional and amateur athletes performing strenuous exercise in order to reduce the undesirable effects of the oxidative stress and inflammation signalling elicited during high-intensity exercise.

show abstract

“…Recently, it has been suggested that IL-6 acts as an energy sensor, exhibiting local and endocrine metabolic effects (278,279). IL-6 and other cytokines such as IL-8, cyclooxygenase2, and TNF-a are significantly activated after unaccustomed muscle contractions, which cause microdamage to sarcomeres (54,208). The repair of the damage by satellite cells is crucial, as these cells divide and fuse to form myotubes.…”

Section: Exercise-induced Inflammation and Rosmentioning

confidence: 99%

Oxygen Consumption and Usage During Physical Exercise: The Balance Between Oxidative Stress and ROS-Dependent Adaptive Signaling

Radák

Zhao

Koltai

et al. 2013

Antioxidants & Redox Signaling

503

425

View full text Add to dashboard Cite

The complexity of human DNA has been affected by aerobic metabolism, including endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an important role in the evolution of Homo sapiens, and oxygen was not important just for survival, but it was crucial to redox-mediated adaptation. The metabolic challenge during physical exercise results in an elevated generation of reactive oxygen species (ROS) that are important modulators of muscle contraction, antioxidant protection, and oxidative damage repair, which at moderate levels generate physiological responses. Several factors of mitochondrial biogenesis, such as peroxisome proliferator-activated receptor-c coactivator 1a (PGC-1a), mitogen-activated protein kinase, and SIRT1, are modulated by exercise-associated changes in the redox milieu. PGC-1a activation could result in decreased oxidative challenge, either by upregulation of antioxidant enzymes and/or by an increased number of mitochondria that allows lower levels of respiratory activity for the same degree of ATP generation. Endogenous thiol antioxidants glutathione and thioredoxin are modulated with high oxygen consumption and ROS generation during physical exercise, controlling cellular function through redox-sensitive signaling and proteinprotein interactions. Endurance exercise-related angiogenesis, up to a significant degree, is regulated by ROSmediated activation of hypoxia-inducible factor 1a. Moreover, the exercise-associated ROS production could be important to DNA methylation and post-translation modifications of histone residues, which create heritable adaptive conditions based on epigenetic features of chromosomes. Accumulating data indicate that exercise with moderate intensity has systemic and complex health-promoting effects, which undoubtedly involve regulation of redox homeostasis and signaling. Antioxid. Redox Signal. 18, 1208Signal. 18, -1246

show abstract

Eccentric contraction induces inflammatory responses in rat skeletal muscle: role of tumor necrosis factor-α

Cited by 85 publications

References 53 publications

Effects of eccentric exercise on toll-like receptor 4 signaling pathway in peripheral blood mononuclear cells

Effects of eccentric exercise on toll-like receptor 4 signaling pathway in peripheral blood mononuclear cells

Phlebodium decumanum is a natural supplement that ameliorates the oxidative stress and inflammatory signalling induced by strenuous exercise in adult humans

Oxygen Consumption and Usage During Physical Exercise: The Balance Between Oxidative Stress and ROS-Dependent Adaptive Signaling

Contact Info

Product

Resources

About