Ecabet sodium, a locally acting antiulcer drug, inhibits urease activity of Helicobacter pylori

Ito, Yutaka; Shibata, Kazuo; Hongo, Aiko; Kinoshita, Mine

doi:10.1016/s0014-2999(97)01622-1

Cited by 41 publications

(38 citation statements)

References 22 publications

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“…Ecabet sodium inhibits the urease activity of H. pylori and the growth of H. pylori in acidic conditions (15) (16). This anti-bacterial effect of ecabet sodium is observed even in strains resistant to clarithromycin and metronidazole (16).…”

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confidence: 98%

Triple Therapy with Ecabet Sodium, Amoxicillin and Lansoprazole for 2 Weeks as the Rescue Regimen for H. pylori Infection

et al. 2011

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Background/Aim Ecabet sodium has an anti-H. pylori effect. We assessed the efficacy of ecabet sodium in the rescue therapy for the eradication of H. pylori. Methods A total of 74 patients with failed eradication of H. pylori after triple therapy with lansoprazole 30 mg bid, amoxicillin 750 mg bid and clarithromycin 200 mg bid were enrolled. They were randomly assigned to the three treatment groups as follows: LAC, lansoprazole 30 mg + amoxicillin 750 mg + clarithromycin 200 mg bid for 1 week; LAC2E, lansoprazole 30 mg bid + amoxicillin 750 mg bid + clarithromycin 200 mg bid + ecabet sodium 2 g bid for 1 week; and LA2E, lansoprazole 30 mg bid + amoxicillin 750 mg bid + ecabet sodium 2 g bid for 2 weeks. Eradication of H. pylori was assessed by the 13C-urea breath test after treatment. Results Eradication rates in intention-to-treat and per-protocol analyses were 20.0% (95% CI: 6.8-40.7) and 20.0% (6.8-40.7) with LAC, respectively, and 16.0% (4.5-36.1) and 17.4% (5.0-38.8) with LAC2E. In contrast, respective rates with LA2E were 75% (53.3-90.2) and 85.7% (63.7-97.0), which were significantly higher than those with LAC (p<0.001 for both ITT and PP) and LAC2E (p<0.001 for both ITT and PP). Conclusion Triple therapy with ecabet sodium, lansoprazole and amoxicillin for 2 weeks was effective as the rescue therapy after failure of the standard clarithromycin-based regimen.

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confidence: 98%

Triple Therapy with Ecabet Sodium, Amoxicillin and Lansoprazole for 2 Weeks as the Rescue Regimen for H. pylori Infection

et al. 2011

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“…This agent has a high affinity for gastric mucus and is known to inhibit pepsin (29) and urease activities (15). Ecabet is also suggested to improve efficacy of antibiotic therapy for H. pylori infection in patients with peptic ulcer (1,16).…”

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Ecabet sodium inhibitsHelicobacter pylorilipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells

Kusumoto

Kawahara

Kuwano

et al. 2005

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Recently we have reported an open-labeled study based on these hypothesis using ecabet sodium, a novel nonabsorbable locally acting antigastric ulcer agent, has been shown to enhance topically mucosal defensive factors, such as endogenous prostaglandins [43,44]. This study showed that ecabet sodium enema is a potentially useful therapy for treating distal ulcerative colitis [44].…”

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confidence: 83%

Adaptive cytoprotection against acetic acid induced colonic injury in rats

Kono

Yoneda

Ohara

et al. 2001

Int J Colorectal Dis

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Ecabet sodium, a locally acting antiulcer drug, inhibits urease activity of Helicobacter pylori

Cited by 41 publications

References 22 publications

Triple Therapy with Ecabet Sodium, Amoxicillin and Lansoprazole for 2 Weeks as the Rescue Regimen for H. pylori Infection

Triple Therapy with Ecabet Sodium, Amoxicillin and Lansoprazole for 2 Weeks as the Rescue Regimen for H. pylori Infection

Ecabet sodium inhibitsHelicobacter pylorilipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells

Adaptive cytoprotection against acetic acid induced colonic injury in rats

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