EBV-Related Diffuse Large B-Cell Lymphoma in a Patient with Angioimmunoblastic T-Cell Lymphoma

Epstein-Barr virus-positive, CD30-positive, diffuse large B-cell lymphoma in a patient with angioimmunoblastic T-cell lymphoma

“…The commonest type of B-cell lymphoma is the DLBCL, but other forms of B-cell lymphoproliferative disease have been described, including mixed type II cryoglobulinemia and small lymphocytic lymphoma/chronic lymphocytic leukemia. 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 The development of secondary B-cell lymphomas with a DLBCL morphology may portend a more aggressive clinical course with multiple sites of lymphomatous dissemination, including bone marrow, duodenal bulb, lung, ileum, soft tissue, and skin. 3 , 4 , 5 , 6 , 7 , 8 …”

“… 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 The development of secondary B-cell lymphomas with a DLBCL morphology may portend a more aggressive clinical course with multiple sites of lymphomatous dissemination, including bone marrow, duodenal bulb, lung, ileum, soft tissue, and skin. 3 , 4 , 5 , 6 , 7 , 8 …”

“…In addition to our case, 5 additional cases have been reported of skin involvement by secondary, EBV-positive, diffuse large B-cell lymphoma in AITL represented by 2 women and 3 men, ranging from 49 to 77 years of age, presenting with a solitary thigh lesion in 1 case and a more diffuse multifocal cutaneous eruption involving the trunk and extremities in the other 4 cases. 3 , 4 , 5 , 6 , 7 , 8 The DLBCL developed 6-21 months after the diagnosis of AITL, including 2 cases in which it developed after completion of AITL chemotherapy. Three patients died of lymphoma, and 2 patients are in remission.…”

Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma

“…A number of reports showed that AITL may be linked to viral infections, such as Epstein-Barr virus (EBV). High EBV viremia upon presentation was associated in some reports with a worse response, disease progression, or evolution to aggressive B cell lymphoma [ 3 , 4 , 5 , 6 , 7 ]. Neoplastic TFH cells are postulated to have a role in AITL initiation and development through the deregulation of cytokines, such as interleukin-21 (IL-21), IL-4, and CXCL13 secreted by TFH cells that play important roles in germinal center cells’ interactions and activation [ 8 ].…”