EBV-negative Fibrin-Associated Large B-Cell Lymphoma Arising in Thyroid Hyperplastic Nodule: Report of a Case and Literature Review

Abstract

Fibrin-associated large B-cell lymphoma is a rare microscopic-sized tumor, typically representing an unexpected finding at sites rich in chronic fibrin deposition. It is associated with Epstein-Barr virus, and has been reported to occur in a wide variety of anatomic sites and clinical scenarios. We report a case arising in a thyroid hyperplastic nodule, only the second case reported in this location. Notably, this is only the fourth case of fibrin-associated large B-cell lymphoma that is not associated with Epstein-Barr virus. We provide a literature review on the clinico-pathological characteristics and outcome of this newly characterized indolent lymphoma type, which has only recently been separated out from the pathologically similar but highly aggressive large B-cell lymphoma associated with chronic inflammation.

Cytological Features of Fibrin-associated Diffuse Large B-cell Lymphoma Arising in Retroperitoneal Pseudocyst: The First Case Report

“…However, chronic inflammation in a fibrin-rich microenvironment probably plays a critical role in type III EBV latency (13). Like our patient, 95.4% of previously published FA-DLBCL cases were related to EBV (7), supporting that FA-DLBCL is an EBV-associated large B-cell lymphoma.…”

“…Herein, we described a rare case of FA-DLBCL arising in a retroperitoneal pseudocyst. Ho et al (7) summarized 87 patients with FA-DLBCL. Their literature review revealed that patients with FA-DLBCL had many types of underlying medical conditions, such as cardiac myxoma, thrombus, hematoma, aneurysms, prosthetic valves, breast implants, and cystic lesions at various locations (8)(9)(10)(11)(12).…”