EBV miR-BART10-3p Promotes Cell Proliferation and Migration by Targeting DKK1

Min, Kyoungmi; Lee, Suk Kyeong

doi:10.7150/ijbs.30099

Cited by 26 publications

(16 citation statements)

References 49 publications

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“…showed that miR-BART7 promoted anchorage-independent growth. Additionally, several studies showed that BART miRNAs promoted cell migration [54,55]. Based on our KLF2 knockdown and overexpression data, the phenotype induced by miR-BART17-5p may be due to the decreased expression of KLF2.…”

Section: Discussionsupporting

confidence: 55%

Epstein-Barr Virus miR-BART17-5p Promotes Migration and Anchorage-Independent Growth by Targeting Kruppel-Like Factor 2 in Gastric Cancer

2020

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Epstein-Barr virus (EBV) infects more than 90% of the global population and is associated with a variety of tumors including nasopharyngeal carcinoma, Hodgkin lymphoma, natural killer/T lymphoma, and gastric carcinoma. In EBV-associated gastric cancer (EBVaGC), highly expressed EBV BamHI A rightward transcripts (BART) miRNAs may contribute to tumorigenesis with limited viral antigens. Despite previous studies on the targets of BART miRNAs, the functions of all 44 BART miRNAs have not been fully clarified. Here, we used RNA sequencing data from the Cancer Genome Atlas to find genes with decreased expression in EBVaGC. Furthermore, we used AGS cells infected with EBV to determine whether expression was reduced by BART miRNA. We showed that the expression of Kruppel-like factor 2 (KLF2) is lower in AGS-EBV cells than in the AGS control. Using bioinformatics analysis, four BART miRNAs were selected to check whether they suppress KLF2 expression. We found that only miR-BART17-5p directly down-regulated KLF2 and promoted gastric carcinoma cell migration and anchorage-independent growth. Our data suggest that KLF2 functions as a tumor suppressor in EBVaGC and that miR-BART17-5p may be a valuable target for effective EBVaGC treatment.

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Section: Discussionsupporting

confidence: 55%

Epstein-Barr Virus miR-BART17-5p Promotes Migration and Anchorage-Independent Growth by Targeting Kruppel-Like Factor 2 in Gastric Cancer

2020

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“…The EBV genome contains two regions that encode more than 40 miRNAs that regulate the expression of viral and human genes, such as ebv-miR-BART-1-3p, -2-5p, -3-3p, -4-5p, -5-5p, -7-3p, -9-3p, -10-3p, -17-5p, -10-3p, -18-5p, BART11, etc. (62)(63)(64)(65)(66)(67). Studies suggest that EBV miRNAs affect immune response and antigen presentation and recognition, alter the communication between T-and B-cells, drive the production of antibodies during infection, and play a role in apoptosis.…”

Section: Micrornasmentioning

confidence: 99%

EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives

Sun

Jia

et al. 2020

Front. Oncol.

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Gastric cancer is the fifth most common malignant tumor and second leading cause of cancer-related deaths worldwide. With the improved understanding of gastric cancer, a subset of gastric cancer patients infected with Epstein–Barr virus (EBV) has been identified. EBV-positive gastric cancer is a type of tumor with unique genomic aberrations, significant clinicopathological features, and a good prognosis. After EBV infects the human body, it first enters an incubation period in which the virus integrates its DNA into the host and expresses the latent protein and then affects DNA methylation through miRNA under the action of the latent protein, which leads to the occurrence of EBV-positive gastric cancer. With recent developments in immunotherapy, better treatment of EBV-positive gastric cancer patients appears achievable. Moreover, studies show that treatment with immunotherapy has a high effective rate in patients with EBV-positive gastric cancer. This review summarizes the research status of EBV-positive gastric cancer in recent years and indicates areas for improvement of clinical practice.

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“…These miRNAs are differentially expressed in different cell types and latencies, which have been extensively studied in lymphoma and carcinoma [ 9 – 11 ]. Emerging findings suggest that EBV's miRNAs are involved in regulating innate and adaptive immune responses, cell proliferation and apoptosis, and tumor metastasis [ 12 – 14 ]. EBV-derived noncoding RNAs especially miRNAs can also transfer through exosome and regulate the function for the tumorigenesis [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Oncogenic Role of miR-BART19-3p in Epstein-Barr Virus-Associated Diseases

Zhang

Luo

Xie

et al. 2020

BioMed Research International

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Accumulating evidence so far has shown that EBV’s miRNAs have been found to be involved in cancer progression. However, the comprehensive EBV miRNA expression profiles and their biological significance in EBV-associated diseases are not well documented. A comprehensive profiling of EBV-encoded miRNAs expressed in CAEBV, EBV-HLH, and nasopharyngeal carcinoma (NPC) patients was constructed, and the results showed that miR-BART19-3p was upregulated in all these diseases. Ectopic expression of miR-BART19-3p induced EBV-negative cell proliferation and suppressed cell apoptosis. Molecularly, adenomatous polyposis coli (APC) was identified to be a direct target of miR-BART19-3p, and APC mRNA expression was inversely correlated with miR-BART19-3p in CAEBV samples. Our results demonstrated that miR-BART19-3p contributes to the tumorigenesis of EBV-associated diseases and may be a potential therapeutic target.

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EBV miR-BART10-3p Promotes Cell Proliferation and Migration by Targeting DKK1

Cited by 26 publications

References 49 publications

Epstein-Barr Virus miR-BART17-5p Promotes Migration and Anchorage-Independent Growth by Targeting Kruppel-Like Factor 2 in Gastric Cancer

Epstein-Barr Virus miR-BART17-5p Promotes Migration and Anchorage-Independent Growth by Targeting Kruppel-Like Factor 2 in Gastric Cancer

EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives

The Oncogenic Role of miR-BART19-3p in Epstein-Barr Virus-Associated Diseases

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