EBV-associated nasopharyngeal carcinomas: from epidemiology to virus-targeting strategies

Busson, P.; Keryer, C.; Ooka, Tadamassa; Corbex, Marilys

doi:10.1016/j.tim.2004.06.005

Cited by 122 publications

(89 citation statements)

References 27 publications

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“…Most cases have minimal epithelial maturation and are classified as undifferentiated (WHO type III) or poorly differentiated non-keratinizing (WHO type II) tumours. Some cases are differentiated keratinizing squamous-cell carcinomas (WHO type I) [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…The mechanisms underlying the development of NPC remain largely unknown [1,2,4]. Several factors have been identified in its aetiology in recent years, including infection of the Epstein-Barr virus (EBV), environmental risk factors and genetic susceptibility [1,2,5].…”

Section: Introductionmentioning

confidence: 99%

“…Several factors have been identified in its aetiology in recent years, including infection of the Epstein-Barr virus (EBV), environmental risk factors and genetic susceptibility [1,2,5]. Of these aetiological factors, EBV infection appears to be the most important one [1][2][3][4]6].…”

Section: Introductionmentioning

confidence: 99%

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Mechanisms of cell immortalization mediated by EB viral activation of telomerase in nasopharyngeal carcinoma

et al. 2006

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Nasopharyngeal carcinoma (NPC) is a common cancer in Southern China and Southeast Asia. The disease is a poorly differentiated carcinoma without effective cure, and the mechanism underlying its development remains largely unknown. Of several factors identified in NPC aetiology in recent years, Epstein-Barr virus (EBV) infection has emerged to be most important. In almost all NPC cells, EBV uses several intracellular mechanisms to cause oncogenic evolution of the infected cells. One such mechanism by which EBV infection induces cellular immortalization is believed to be through the activation of telomerase, an enzyme that is normally repressed but becomes activated during cancer development. Studies show that greater than 85% of primary NPC display high telomerase activity by mechanisms involving EBV infection, consistent with the notion that EBV is commonly involved in inducing cell immortalization. More recently, different EBV proteins have been shown to activate or inhibit the human telomerase reverse transcriptase gene, by modulating intracellular signalling pathways. These findings suggest a new model with a number of challenges towards our understanding, molecular targeting and therapeutic intervention in NPC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mechanisms of cell immortalization mediated by EB viral activation of telomerase in nasopharyngeal carcinoma

et al. 2006

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“…Major risk factors include Epstein -Barr virus (EBV) infection, genetic susceptibility, diet and other environmental exposures (Hildesheim and Levine, 1993;Jeannel et al, 1999;Yu and Yuan, 2002;Busson et al, 2004;Chang and Adami, 2006). In North Africa, cigarette smoking, alcohol consumption and cooking in the main living room during childhood have been suggested to be associated with increased NPC risk (Jeannel et al, 1990;Ammor et al, 2003).…”

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confidence: 99%

Cannabis, tobacco and domestic fumes intake are associated with nasopharyngeal carcinoma in North Africa

et al. 2009

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Cigarette smoking and snuff (tobacco powder with additives) intake were significantly associated with differentiated NPC but not with undifferentiated carcinoma (UCNT), which is the major histological type of NPC in these populations. As demonstrated by a stratified permutation test and by conditional logistic regression, marijuana smoking significantly elevated NPC risk independently of cigarette smoking, suggesting dissimilar carcinogenic mechanisms between cannabis and tobacco. Domestic cooking fumes intake by using kanoun (compact charcoal oven) during childhood increased NPC risk, whereas exposure during adulthood had less effect. Neither alcohol nor shisha (water pipe) was associated with risk. CONCLUSION: Tobacco, cannabis and domestic cooking fumes intake are risk factors for NPC in western North Africa.

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“…However, lymph node dissection in the neck can be performed in patients with bulky N2 or N3 disease (Busson et al, 2004) or if the cancer persists or recurs in the cervical lymph nodes after radiotherapy (Wang, 1987;Lee et al, 1997). If the residual or recurrent tumor in the nasopharynx is too large or has invaded into the paranasopharyngeal space, nasopharyngectomy may be performed.…”

Section: Treatmentmentioning

confidence: 99%

<B>Nasopharyngeal Carcinoma: an Enigmatic Tumor</B>

Tay

Tan²,

Yip

et al. 2008

Annu Rev Biomed Sci

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EBV-associated nasopharyngeal carcinomas: from epidemiology to virus-targeting strategies

Cited by 122 publications

References 27 publications

Mechanisms of cell immortalization mediated by EB viral activation of telomerase in nasopharyngeal carcinoma

Mechanisms of cell immortalization mediated by EB viral activation of telomerase in nasopharyngeal carcinoma

Cannabis, tobacco and domestic fumes intake are associated with nasopharyngeal carcinoma in North Africa

<B>Nasopharyngeal Carcinoma: an Enigmatic Tumor</B>

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