EBV-associated Burkitt lymphoma in Taiwan is not age-related

Chen, Bo Jung; Chang, Sheng Tsung; Weng, Shih‐Feng; Huang, Wan Ting; Chu, Pei Yi; Hsieh, Pin‐Pen; Jung, Yun Chih; Kuo, Chun Chi; Chuang, Yu Ting; Chuang, Shih Sung

doi:10.3109/10428194.2015.1076928

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…BL is composed by mature B-cells positive for CD19, CD20, CD22 and CD79a, also exhibiting immunologic similarity to germinal center cells rather than activated B-cells, being also positive for Bcl-6, CD10 and negative for MUM-1, CD44, CD138 and Bcl-2 1. These findings are compatible with the present case, with the exception of EBV status, since only in geographic regions such as South Asia, Middle Eastern and South America, the EBV-positive BL rates are high (50-80%) 17 , 18…”

Section: Discussionsupporting

confidence: 93%

Intraoral EBV-positive sporadic Burkitt lymphoma in an elderly patient with bilateral presentation

Pedraza¹,

Arboleda²,

Sánchez‐Romero³

et al. 2019

Autops. Case Rep.

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Sporadic Burkitt lymphoma (SBL) is a variant of Burkitt lymphoma that occurs worldwide, affecting mainly children and young adults. Association with Epstein-Barr virus (EBV) can be identified in approximately 20-30% of cases. Herein we described a case of a 63-year-old male presenting intraoral bilateral mandibular swelling, subjacent to fixed dental prosthesis, with one month of duration. Incisional biopsies were performed, and after two days, the patient was hospitalized due to malaise and breathing difficulty, and died after a week when an abdominal tumor was detected. The mandibular biopsies revealed a diffuse proliferation of medium-sized monomorphic atypical lymphoid cells exhibiting numerous mitoses and areas of “starry-sky” pattern. The tumor showed immunohistochemical positivity for CD20, CD10, Bcl-6, and Ki-67 (≈ 100%); it was negative for CD3, Bcl-2, Vs38c, and MUM-1. Positivity for EBV was found by in situ hybridization. The final diagnosis was intraoral SBL positive for EBV. Clinical, morphological and molecular criteria are necessary for the correct diagnosis of aggressive B-cell neoplasms positive for EBV in elderly patients.

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Section: Discussionsupporting

confidence: 93%

Intraoral EBV-positive sporadic Burkitt lymphoma in an elderly patient with bilateral presentation

Pedraza¹,

Arboleda²,

Sánchez‐Romero³

et al. 2019

Autops. Case Rep.

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“…Adult sBL tends to have higher rates of EBV positivity, nodal presentation, along with poorer outcome, and often more variable pathologic features leading to designations of plasmacytoid or atypical-BL (3). These differences within sBL have raised the suggestion that adult sBL should be considered a separate entity (4) as well as EBV-positive and EBV-negative tumors (5). …”

Section: Introductionmentioning

confidence: 99%

Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type–Specific Differences

Kaymaz

Oduor

et al. 2017

Molecular Cancer Research

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Endemic Burkitt lymphoma (eBL) is the most common pediatric cancer in malaria-endemic equatorial Africa and nearly always contains Epstein-Barr virus (EBV), unlike sporadic Burkitt Lymphoma (sBL) that occurs with a lower incidence in developed countries. Given these differences and the variable clinical presentation and outcomes, we sought to further understand pathogenesis by investigating transcriptomes using RNA sequencing (RNAseq) from multiple primary eBL tumors compared to sBL tumors. Within eBL tumors, minimal expression differences were found based on: anatomical presentation site, in-hospital survival rates, and EBV genome type; suggesting that eBL tumors are homogeneous without marked subtypes. The outstanding difference detected using surrogate variable analysis was the significantly decreased expression of key genes in the immunoproteasome complex (PSMB9/β1i, PSMB10/β2i, PSMB8/β5i, and PSME2/PA28β) in eBL tumors carrying type 2 EBV compared to type 1 EBV. Secondly, in comparison to previously published pediatric sBL specimens, the majority of the expression and pathway differences was related to the PTEN/PI3K/mTOR signaling pathway and was correlated most strongly with EBV status rather than geographic designation. Third, common mutations were observed significantly less frequently in eBL tumors harboring EBV type 1, with mutation frequencies similar between tumors with EBV type 2 and without EBV. In addition to the previously reported genes, a set of new genes mutated in BL including TFAP4, MSH6, PRRC2C, BCL7A, FOXO1, PLCG2, PRKDC, RAD50, and RPRD2 were identified. Overall, these data establish that EBV, particularly EBV type 1, supports BL oncogenesis alleviating the need for certain driver mutations in the human genome.

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“…Studies were categorized based on the socio-demographic index (SDI) into five categories: high SDI [ 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 139 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 151 , 153 , 154 , 155 , 157 , 158 , 159 , 161 , 163 , 165 , 166 , 167 , 170 , 171 , 176 ], high–middle SDI [ 91 , 94 , 95 , 96 , 99 , 100 , 102 , 103 , 107 , 109 , 112 , 116 , 138 , 140 , 141 ,…”

Section: Resultsmentioning

confidence: 99%

Worldwide Prevalence of Epstein–Barr Virus in Patients with Burkitt Lymphoma: A Systematic Review and Meta-Analysis

et al. 2023

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Burkitt lymphoma (BL) is a form of B-cell malignancy that progresses aggressively and is most often seen in children. While Epstein–Barr virus (EBV) is a double-stranded DNA virus that has been linked to a variety of cancers, it can transform B lymphocytes into immortalized cells, as shown in BL. Therefore, the estimated prevalence of EBV in a population may assist in the prediction of whether this population has a high risk of increased BL cases. This systematic review and meta-analysis aimed to estimate the prevalence of Epstein–Barr virus in patients with Burkitt lymphoma. Using the appropriate keywords, four electronic databases were searched. The quality of the included studies was assessed using the Joanna Briggs Institute’s critical appraisal tool. The results were reported as percentages with a 95% confidence interval using a random-effects model (CI). PROSPERO was used to register the protocol (CRD42022372293), and 135 studies were included. The prevalence of Epstein–Barr virus in patients with Burkitt lymphoma was 57.5% (95% CI: 51.5 to 63.4, n = 4837). The sensitivity analyses demonstrated consistent results, and 65.2% of studies were of high quality. Egger’s test revealed that there was a significant publication bias. EBV was found in a significantly high proportion of BL patients (more than 50% of BL patients). This study recommends EBV testing as an alternative for predictions and the assessment of the clinical disease status of BL.

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EBV-associated Burkitt lymphoma in Taiwan is not age-related

Cited by 8 publications

References 32 publications

Intraoral EBV-positive sporadic Burkitt lymphoma in an elderly patient with bilateral presentation

Intraoral EBV-positive sporadic Burkitt lymphoma in an elderly patient with bilateral presentation

Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type–Specific Differences

Worldwide Prevalence of Epstein–Barr Virus in Patients with Burkitt Lymphoma: A Systematic Review and Meta-Analysis

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