Ebola Virus RNA in Semen from an HIV-Positive Survivor of Ebola

Purpura, Lawrence; Rogers, Emerson; Baller, April; White, Stephen; Soka, Moses J; Choi, Mary J.; Mahmoud, Nuha; Wasunna, Christine; Massaquoi, Moses; Kollie, Jomah; Dweh, Straker; Bemah, Philip; Ladele, Victor; Kpaka, Jonathan; Jawara, Mary; Mugisha, Margaret; Subah, Onyekachi; Faikai, Mylene; Bailey, Jeff A.; Rollin, Pierre E.; Marston, Barbara J.; Nyenswah, Tolbert; Gasasira, Alex; Knust, Barbara; Nichol, Stuart T.; Williams, Desmond E.

doi:10.3201/eid2304.161743

Cited by 24 publications

(20 citation statements)

References 6 publications

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“…Reported sequelae include arthralgia, cardiac valvulopathy, parotid gland inflammation, peripheral paresthesia or dysesthesia, and gastrointestinal motility disorders 10 – 14 . Semen may contain detectable EBOV RNA for more than 500 days following recovery, and EBOV RNA has been detected in breast milk of a subclinically infected mother 15 , 16 . Replicating EBOV has been isolated from the cerebrospinal fluid of an EVD survivor suffering a disease relapse and from the aqueous humor of the eye of another survivor 17 , 18 .…”

Section: Introductionmentioning

confidence: 99%

Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues in the Ebola virus disease guinea pig model

Cooper

Huzella

Johnson

et al. 2018

Sci Rep

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Survivors of Ebola virus infection may become subclinically infected, but whether animal models recapitulate this complication is unclear. Using histology in combination with immunohistochemistry and in situ hybridization in a retrospective review of a guinea pig confirmation-of-virulence study, we demonstrate for the first time Ebola virus infection in hepatic oval cells, the endocardium and stroma of the atrioventricular valves and chordae tendinae, satellite cells of peripheral ganglia, neurofibroblasts and Schwann cells of peripheral nerves and ganglia, smooth muscle cells of the uterine myometrium and vaginal wall, acini of the parotid salivary glands, thyroid follicular cells, adrenal medullary cells, pancreatic islet cells, endometrial glandular and surface epithelium, and the epithelium of the vagina, penis and, prepuce. These findings indicate that standard animal models for Ebola virus disease are not as well-described as previously thought and may serve as a stepping stone for future identification of potential sites of virus persistence.

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Section: Introductionmentioning

confidence: 99%

Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues in the Ebola virus disease guinea pig model

Cooper

Huzella

Johnson

et al. 2018

Sci Rep

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“…Deen et al [ 4 ] detected EBOV RNA in the semen of 11 (26%) of 43 men sampled at 7 to 9 months after EVD onset, whereas Sow et al [ 9 ] in Guinea found evidence of EBOV RNA in semen collected from only 2 of 31 (7%) men within a similar time period. There are even fewer data regarding the presence of EBOV RNA in the semen of EVD survivors further out from their disease onset, although cases of detectable viral RNA in the semen of men 407 to 565 days after Ebola Treatment Unit (ETU) release have been reported [ 2 , 7 , 10 , 11 ].…”

mentioning

confidence: 99%

Ebola Virus Ribonucleic Acid Detection in Semen More Than Two Years After Resolution of Acute Ebola Virus Infection

Fischer

Brown

Wohl

et al. 2017

Open Forum Infectious Diseases

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Among 149 men who survived Ebola virus disease (EVD) and donated semen 260–1016 days after EVD onset, Ebola virus (EBOV) ribonucleic acid (RNA) was detected in 13 (9%). Of 137 men who donated semen 2 years after EVD onset, 11 (8%) had an EBOV RNA-positive specimen. The mechanism underlying the persistence of EBOV RNA in semen is unclear, and it is unclear whether the detection of viral RNA represents the presence of infectious virus.

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“…There are significant public safety implications associated with EBOV persistence in immune-privileged sites [11]. Besides ocular fluid, it has been reported that EBOV has been detected in semen 18.5 months after discharge from the Ebola Treatment Unit [12]. Sexual transmission of EBOV 470 and 179 days after symptom onset has been confirmed in cases in Guinea and Liberia, respectively [13,14].…”

Section: Persistence Of Ebov In Ocular Fluid and Other Immune-privilegementioning

confidence: 99%

Cataract Management in Ebola Virus Disease Survivors: Clinical and Scientific Implications

Berry

Shantha

et al. 2019

Future Virol.

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Ebola Virus RNA in Semen from an HIV-Positive Survivor of Ebola

Cited by 24 publications

References 6 publications

Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues in the Ebola virus disease guinea pig model

Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues in the Ebola virus disease guinea pig model

Ebola Virus Ribonucleic Acid Detection in Semen More Than Two Years After Resolution of Acute Ebola Virus Infection

Cataract Management in Ebola Virus Disease Survivors: Clinical and Scientific Implications

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