“…So that's why it is an integral part of various cultures and plays a key role in many shamanistic traditions. In pre-Columbian North America, various civilizations preferred it for smoking and for many other purposes e.g., healing ailments (especially to cure earaches, cuts and burns, snake bites) respiratory diseases, urinary ailments, nervous ailments, fever, convulsions and skin diseases [9,[17][18][19][20][21][22][23]. Brief description of tobacco usage history in medicine is presented in Table 2.…”