2006
DOI: 10.1038/sj.emboj.7601314
|View full text |Cite
|
Sign up to set email alerts
|

EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN

Abstract: Epstein-Barr virus (EBV)-encoded small RNAs (EBERs) are nonpolyadenylated, untranslated RNAs, exist most abundantly in latently EBV-infected cells, and are expected to show secondary structures with many short stemloops. Retinoic acid-inducible gene I (RIG-I) is a cytosolic protein that detects viral double-stranded RNA (dsRNA) inside the cell and initiates signaling pathways leading to the induction of protective cellular genes, including type I interferons (IFNs). We investigated whether EBERs were recognize… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

5
253
0
2

Year Published

2007
2007
2015
2015

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 277 publications
(265 citation statements)
references
References 33 publications
(83 reference statements)
5
253
0
2
Order By: Relevance
“…Interestingly, the cytoplasmic receptor for uncapped 5Ј-phosphorylated RNA, RIG-I (retinoic acid-inducible gene I), has been recently demonstrated to trigger IFN-␣/␤ responses in cells infected by EBV in vitro (22), further supporting a possible role for RNA sensing in the detection of and the response to DNA virus infection. In infected cells, viral mRNAs locate into the cytosol and are therefore accessible to RIG-I.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, the cytoplasmic receptor for uncapped 5Ј-phosphorylated RNA, RIG-I (retinoic acid-inducible gene I), has been recently demonstrated to trigger IFN-␣/␤ responses in cells infected by EBV in vitro (22), further supporting a possible role for RNA sensing in the detection of and the response to DNA virus infection. In infected cells, viral mRNAs locate into the cytosol and are therefore accessible to RIG-I.…”
Section: Discussionmentioning
confidence: 99%
“…Some DNA viruses, including adenovirus, herpes simplex virus 1 (HSV-1) and Epstein-Barr virus (EBV), induce IFN-β production in a RIG-I dependent matter (Cheng et al, 2007;Rasmussen et al, 2007;Samanta et al, 2006). To determine whether Pol-III plays a role in IFN induction by DNA viruses, we treated Raw264.7 cells with ML-60218 and then infected the cells with adenovirus, HSV-1 or Sendai virus (RNA virus as a control).…”
Section: Pol-iii Mediates Ifn-β Induction By Dna Virusesmentioning
confidence: 99%
“…EBVassociated gene products like EBNA1 and LMP1 were reported to modify the ubiquitin -proteasome activity and affect proteolysis of various cellular proteins including NF-kB (Masucci, 2004). In addition, EBERs appear to be involved in modulation of cellular response and were reported to activate NF-kB-signalling pathway (Nambo and Takada, 2002;Samanta et al, 2006). These observations strongly argue that the presence of EBV must render NKL more resistant to lethal stress like DNA damage at least partially through the NF-kB pathway.…”
Section: Discussionmentioning
confidence: 86%