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Abstract

Objective: To determine the immunomodulatory activity of leaves of Rumex vesicarius Linn. and Symplocos racemosa Roxb. Methods: The ethyl acetate and ethanolic extract of Rumex Vesicarius Linn. and ethanolic and N-hexane extract of Symplocos racemosa Roxb. were administered orally at the dosage level of 200 mg/kg/day and 400 mg/kg/day each according to the body weight of Rat. The assessments of immunomodulatory activity were carried out by using Carbon Clearance Test and Delayed Type Hypersensitivity Test. Result: Oral administration of all the extract of Rumex vesicarius Linn. and Symplocos racemosa Roxb. significantly (P < 0.0001) showed an increase in phagocytic activity and DTH response in Rat at an experimental dose. The study also comprises the acute toxicity study and preliminary phytochemical screening. Conclusion:The study demonstrate that all the extract of Rumex vesicarius Linn. and Symplocos racemosa Roxb. shows the significant immunomodulatory effect on both humoral as well as cell-mediated immunity.