Eaux usées et Escherichia coli producteur de β-lactamases à spectre étendu

Bréchet, C.; Hocquet, Didier; Bertrand, Xavier

doi:10.1016/j.antinf.2015.03.001

Cited by 3 publications

(6 citation statements)

References 43 publications

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“…This finding correlates with numerous studies carried out in Africa, which reported the presence of bla CTX-M genes with a predominance of CTX-M-1 isolated from wastewaters [17][18][19]22,[30][31][32][33][34][35]. Nevertheless, ESBL genes identified in the bacteria present in wastewaters are variable in nature with CTX-M1 being predominant in the CTX-M group [36]. Their presence is often of chromosomal origin and the gene is found in Kluyvera spp [9].…”

Section: Discussionsupporting

confidence: 87%

Characterization of extended-spectrum beta-lactamase and carbapenemase genes in bacteria from environment in Burkina Faso

Muhigwa,

Sanou,

Kantagba

et al. 2023

J Infect Dev Ctries

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Introduction: This study aimed to characterize extended-spectrum beta-lactamase (ESBL) and carbapenemase genes in bacteria from the environment in Bobo-Dioulasso, Burkina Faso. Methodology: This study was conducted from January 18 to December 31, 2019. Environmental samples were collected from the effluents of Souro Sanou University Hospital Center and the wastewater treatment plant at Bobo-Dioulasso. MacConkey agar media supplemented with 4 µg/mL cefotaxime was used for bacterial growth, and identification of bacteria was performed using API 20E system (BioMerieux SA, Lyon, France). Antibiotic susceptibility testing, synergy test, carbapenem inactivation method and molecular characterization were performed. Results: A total of 180 bacterial isolates were identified from the different sites with a predominance of Klebsiella oxytoca and Klebsiella pneumoniae (27.5%). All 180 bacterial isolates were ESBL producers and 18 (10.0%) of them produced carbapenemases. Out of the 180 bacterial isolates, DNAs of 98.9% (178/180) bacterial isolates were extracted and tested through polymerase chain reaction (PCR) for characterization of resistant genes. The study showed that 89.8% (160/178) carried the bla-CTX-M genes including 54.4 (87/160) from hospital effluents and 45.6 (73/160) from the wastewater treatment plant. Regarding the carriage of carbapenemase genes, 7.9 (14/178) blaNDM-1 was found in all the sites including 71.4% (10/14) from hospital effluents and 28.6 (4/14) from the wastewater treatment plant. blaOXA-48-like was only found in bacteria from hospital effluents and represented 2.2% (4/178). Conclusions: This study highlights the need to build hospital effluent treatment plants to reduce the load of resistant bacteria before discharging the effluents into the urban wastewater system.

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Section: Discussionsupporting

confidence: 87%

Characterization of extended-spectrum beta-lactamase and carbapenemase genes in bacteria from environment in Burkina Faso

Muhigwa,

Sanou,

Kantagba

et al. 2023

J Infect Dev Ctries

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“…Numerous studies have found significant quantities of bacteria producing extended-spectrum beta-lactamases (ESBL-producing E. coli) in community and hospital effluents, as well as in bathing waters, with more ESBL-producing E. coli in hospital wastewater than in community wastewater [3]. This can be explained, in part, by a higher frequency and density of carriage among hospitalized patients compared to healthy community carriers [82].…”

Section: Characterization Of Esbls In Wastewatermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Emergence of Antibiotic Residues and Antibiotic Resistant Bacteria in Hospital Wastewater: A Potential Dissemination Pathway into the Environment: A Review

EVOUNG CHANDJA,

Onanga,

Mbehang Nguema

et al. 2024

Preprint

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Medicinal activities carried out within hospitals lead to a high consumption of antibiotics and subsequently result in a high excretion rate of antibiotic residues. These antibiotics consumed in human medicine are not fully absorbed by the body and are often discharged into the environment as biological waste from infected human patients. The significant water consumption in hospitals and the pharmaceutical impact on wastewater from healthcare facilities facilitate the emergence and spread of antibiotic-resistant bacteria and antibiotic-resistant genes in the environment. Hospital effluents could be doubly involved in the dissemination of antibiotic molecules and multidrug-resistant bacteria in various ecosystems. The objective of this study is to characterize hospital effluents by assessing antibiotic concentrations and the diversity of antibiotic-resistant bacteria in these hospital wastewaters and within the environment (aquatic environments; rivers), as well as to inventory the bacteria present and those carrying antibiotic resistance in both hospital wastewater and the environment.

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“…On average, in healthcare facilities, the antibiotic consumption of a hospitalized patient is about ten times higher than the average consumption per capita in households [2]. Furthermore, the significant use of antibiotics in hospitals exerts selective pressure that promotes the emergence of multidrug-resistant bacteria, including extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-EB) [3]. These multidrug-resistant bacteria are then eliminated in wastewater as antibiotic-resistant fecal bacteria (ARFB) and liquid waste [2,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…It is in this context that communal and hospital wastewater plays a key role in the dissemination of antibiotic-resistant bacteria (ARB), such as ESBL-EB [3][4][5][6][7]. Hospital effluents contribute to the 2 contamination of various ecosystems, affecting the habitats of certain animals (small rodents, aquatic animals, etc.)…”

Section: Introductionmentioning

confidence: 99%

Emergence Of Antibiotic Residues And Antibiotic-resistant Bacteria In Hospital Wastewater: A Potential Dissemination Pathway Into The Environment: A Review

EVOUNG CHANDJA,

Onanga,

Mbehang Nguema

et al. 2024

Preprint

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Medicinal activities carried out within hospitals lead to a high consumption of antibiotics and subsequently result in a high excretion rate of antibiotic residues. These antibiotics consumed in human medicine are not fully absorbed by the body and are often discharged into the environment as biological waste from infected human patients. The significant water consumption in hospitals and the pharmaceutical impact on wastewater from healthcare facilities facilitate the emergence and spread of antibiotic-resistant bacteria and antibiotic-resistant genes in the environment. Hospital effluents could be doubly involved in the dissemination of antibiotic molecules and multidrug-resistant bacteria in various ecosystems. The objective of this study is to characterize hospital effluents by assessing antibiotic concentrations and the diversity of antibiotic-resistant bacteria in these hospital wastewaters and within the environment (aquatic environments, rivers), as well as to inventory the bacteria present and those carrying antibiotic resistance in both hospital wastewater and the environment.

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Eaux usées et Escherichia coli producteur de β-lactamases à spectre étendu

Cited by 3 publications

References 43 publications

Characterization of extended-spectrum beta-lactamase and carbapenemase genes in bacteria from environment in Burkina Faso

Characterization of extended-spectrum beta-lactamase and carbapenemase genes in bacteria from environment in Burkina Faso

Emergence of Antibiotic Residues and Antibiotic Resistant Bacteria in Hospital Wastewater: A Potential Dissemination Pathway into the Environment: A Review

Emergence Of Antibiotic Residues And Antibiotic-resistant Bacteria In Hospital Wastewater: A Potential Dissemination Pathway Into The Environment: A Review

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