EAU Guidelines on Male Infertility

Dohle, Gert R.; Colpi, Giovanni M.; Hargreave, T. B.; Papp, G; Jungwirth, A.; Weidner, W.

doi:10.1016/j.eururo.2005.06.002

Cited by 456 publications

(366 citation statements)

References 48 publications

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“…I nfertility is one of the most frequently diagnosed diseases in reproductive health and male-related problems that account for approximately half of all infertility cases 1,2 . A significant proportion of male infertility is accompanied by idiopathic azoospermia, most often presenting as non-obstructive azoospermia (NOA), which occurs in B1% of all adult men 3 .…”

mentioning

confidence: 99%

Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men

et al. 2014

Nat Commun

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Male factor infertility affects one-sixth of couples worldwide, and non-obstructive azoospermia (NOA) is one of the most severe forms. Our previous genome-wide association study (GWAS) identified three susceptibility loci for NOA in Han Chinese men. Here we test promising associations in an extended three-stage validation using 3,608 NOA cases and 5,909 controls to identify additional risk loci. We find strong evidence of three NOA susceptibility loci (Po5.0 Â 10 À 8 ) at 6p21.32 (rs7194, P ¼ 3.76 Â 10 À 19 ), 10q25.3 (rs7099208, P ¼ 6.41 Â 10 À 14 ) and 6p12.2 (rs13206743, P ¼ 3.69 Â 10 À 8 ), as well as one locus approaching genome-wide significance at 1q42.13 (rs3000811, P ¼ 7.26 Â 10 À 8 ). In addition, we investigate the phenotypic effect of the related gene (gek, orthologous to CDC42BPA) at 1q42.13 on male fertility using a Drosophila model. These results advance our understanding of the genetic susceptibility to NOA and provide insights into its pathogenic mechanism.

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mentioning

confidence: 99%

Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men

et al. 2014

Nat Commun

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“…Guidelines for evaluation, such as those issued by the American Urological Association and European Association of Urology, rely to a large extent upon the concept of abnormal SA for management [6,34]. These recommendations understate the limitations of the SA results and do not discuss the paradigm shift that is likely to occur in referrals and management in the light of the recent changes in the WHO reference thresholds [35,36].…”

Section: Semen Analysismentioning

confidence: 99%

“…Men not attempting to achieve conception but who fit into this description and have a desire for future fertility are also candidates for treatment [6,103].…”

Section: Varicocelementioning

confidence: 99%

“…These etiologies may be inherited or acquired. In 37-58 % of the cases, MFI has an unknown origin, which can be idiopathic and unexplained [5][6][7]. Idiopathic MFI is characterized by an unexplained impairment in semen quality with no previous history of fertility problems, in association with normal findings on physical examination and endocrine laboratory testing [6].…”

Section: Definitionsmentioning

confidence: 99%

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Engaging Practicing Gynecologists in the Management of Infertile Men

Agarwal

Hamada

Esteves³

2014

J Obstet Gynecol India

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In the modern era, contemporary management of male infertility has undergone groundbreaking changes with the introduction of new concepts, advanced testing, and therapeutic interventions. As practicing gynecologists are often the first physicians who encounter an infertile couple, it is essential that these clinicians are continuously updated about the new pearls and pitfalls of male infertility management. Semen analysis is commonly ordered by gynecologists. In 2010, the WHO released new cutoff reference values for the semen parameters adopting novel methodology, which has incited much debate. Reference values have been lowered in comparison with previous standards, with a direct clinical implication in decision-making strategies. Specialized sperm-function tests, such as sperm oxidative stress and sperm chromatin integrity assessments, became clinically available, thus offering an opportunity to better understand sperm dysfunctions concealed during routine semen analysis. Furthermore, the initial counseling of azoospermic men by an andrologically well educated gynecologist may alleviate the misconception and distress surrounding the false belief of sterility, and will clarify the 123 available options of percutaneous and microsurgical spermretrieval techniques and assisted conception outcome. Regarding varicocele, which is commonly seen in infertile males, it is now clear that the best treatment option for infertile men with clinical varicocele is the microsurgical vein ligation. Natural conception is significantly improved after varicocelectomy, and recent data suggest that such treatment optimizes reproductive outcome of couples undergoing ICSI or micro-TESE sperm retrieval. Lastly, new therapeutic interventions, including oral antioxidant therapy and lifestyle modifications, have gained increasing attention, as they aid in alleviating male infertility.

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“…Res. 5(10), 710-716 711 before fusing with egg's cell membrane (Oolemma) (2) , motility reflects sperm functional capacity, and considered a valuable indicator of a man's fertilization potential (3) .Several studies have proved the correlation of motility with the fertilization rate in vivo and in vitro, therefore asthenozoospermia is one of the major causes of infertility or reduced fertility in men (4) .…”

Section: Issn: 2320-5407mentioning

confidence: 99%

Effect of in Vitro Activation by Glutathione Supplemented Medium on Sperm Motility, Morphology and Vitality During Sperm Cryopreservation of Asthenozoospermic Men.

Amery¹,

Anbari²,

Mossa.³

2017

IJAR

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Background: Sperm cells from asthenozoospermia have humble motility, Glutathione is added in the medium to increase sperm motility and improve morphologically normal sperm. Cryopreservation of human spermatozoa is one of the best active and acceptable methods to preserve male fertility. However, cryopreservation may lead to changes in sperm structure and decline in sperm functional parameters. Objective: This study has been designed to investigate the effect of Glutathione on certain sperm functional parameters in Asthenozoospemic men before and after cryopreservation. Materials and Methods:The study included forty five asthenozoospermic infertile men. Ejaculated semen were obtained from patients and divided in to two equal portions, first portion was activated by free FertiCult Flushing medium as (control), second portion activated by Glutathione(GSH) in 5 mM concentration. The samples were cryopreserved in liquid nitrogen for one month. All the samples examined for sperm motility, morphology and vitality before and after cryopreservation-thawing, and comparison in these parameters between the two groups done. Results:In vitro activation by GSH resulted in significant (P<0.05) decrease in sperm concentration, highly significant increase (P<0.001) in sperm motility, highly significant decrease in immotile sperm (grade D) and significant increase (P<0.05) in morphologically normal sperm(MNS) compared with pre activation. After cryopreservationthawing, there was significant difference (P<0.05) in certain sperm functional parameters compared with control. Conclusion: There is positive effect and improvement in certain sperm functional parameters after in vitro sperm activation by GSH supplemented medium, before and after cryopreservation.

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EAU Guidelines on Male Infertility

Cited by 456 publications

References 48 publications

Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men

Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men

Engaging Practicing Gynecologists in the Management of Infertile Men

Effect of in Vitro Activation by Glutathione Supplemented Medium on Sperm Motility, Morphology and Vitality During Sperm Cryopreservation of Asthenozoospermic Men.

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