Eating, sleeping and sexual function disorders in women with polycystic ovary syndrome (PCOS): A systematic review and meta‐analysis

Abstract

Purpose We aim to evaluate the association of PCOS with eating, sleeping and sexual function disorders. Methods A comprehensive search including MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus through 01 August 2018 was conducted for studies reporting the prevalence of any eating, sleep or sexual function disorders in patients with PCOS. Independent reviewers selected studies and extracted data. A random‐effects model was utilized to generate pooled odds ratio (OR) and 95% confidence intervals (CI) for binary outcomes, and mean difference (MD) and 95% CI for continuous outcomes. Results We included 36 studies reporting on 349,529 patients. Compared to women without PCOS, women with PCOS were more likely to have bulimia nervosa (OR 1.37; %CI, 1.17 to 1.60), binge eating (OR 2.95; 95%CI, 1.61 to 5.42), or any eating disorder (OR 1.96; 95% CI 1.18 to 3.24); but not anorexia nervosa (OR 0.92; 95%CI, 0.78 to 1.10). Women with PCOS were more likely to have sleep disorders like hypersomnia (OR 4.39; %CI, 1.07 to 18.07) and obstructive sleep apnoea (OR 10.81; %CI, 2.39 to 48.83). Women with PCOS had lower sexual satisfaction as measured on a visual analogue scale (MD −29.67; 95% CI, −36.97 to −22.37), but no difference in Total Female Sexual Function Index (MD −0.06; 95% CI, −0.51 to 0.38). Conclusion PCOS can be associated with an increased risk of eating and sleeping disorders as well as decreased sexual satisfaction. Screening for these disorders in women with PCOS may allow early intervention and improve quality of life.

Obesity and the Risk of Infertility, Gestational Diabetes, and Type 2 Diabetes in Polycystic Ovary Syndrome

“…4,5 On subgroup analyses in the study by Kakoly et al, across healthy weight, overweight, and obese categories, the incidence rates for T2DM were 3.21/1,000 PY, 4.67/1,000 PY, and 8.80/1,000 PY, respectively, in women with PCOS. 6 Women with PCOS with healthy weight had the highest relative risk compared with overweight and obese women (4.68 vs. 3.52 vs. 2.36), highlighting the effect of PCOS per se on the risk of T2DM. This highlights that lean women with PCOS have an intrinsic IR, 43 which is compounded by an extrinsic/lifestyle-related IR in overweight/obese women with PCOS.…”

“…1-3 PCOS is associated with a variety of reproductive, 4 metabolic, 5 and psychological symptoms. [6][7][8] Women diagnosed with PCOS are also likely to experience excess weight, with 60% being overweight or with obesity. 9 The exact etiology of PCOS is yet to be determined; however, insulin resistance (IR) and hyperandrogenism (HA) are thought to underpin the disorder, all of which are exacerbated by obesity.…”

Polikistik over sendromlu kadınlarda cinsel fonksiyon bozukluğu

“…Recent study has been done by Thannickal A et al (16), which had evaluated the relationship between PCOS and eating, sleeping and sexual function disorders. Based on this research, there was also no relationship between FSFI and PCOS.…”

PCOSKBR2: a database of genes, diseases, pathways, and networks associated with polycystic ovary syndrome

“…The prevalence of PCOS globally ranges from 2.2 to 26% contingent upon the population assessed and the criteria used for evaluation 5 . Many of the women with PCOS suffer from various comorbid conditions such as glucose intolerance 6 , type-II diabetes 7 , cardiovascular ailments 8 , anxiety disorders 9 , bipolar disorders 10 and sleep-related disorders 11 .…”