Eating garlic and onion: a matter of life or death

Izzo, Angelo A.; Capasso, Raffaele; Capasso, Francesco

doi:10.1038/sj.bjc.6601918

Cited by 18 publications

(13 citation statements)

References 9 publications

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“…Niether was there granulation tissue formation. This is confirmed by other studies that speculate that Allium sativum has no negative effect on the prosta but rather might be beneficial in the management of prostate cancer (Izzo et al, 2004). …”

Section: Discussionsupporting

confidence: 84%

ABSENCE OF VISIBLE TOXIC EFFECTS ACCOMPANYING THE SHORT-TERM ADMINISTRATION OF AN AQUEOUS EXTRACT OF ALLIUM SATIVA LINN. IN MALE SPRAGUE-DAWLEY RATS

Isaac¹

2014

American Journal of Pharmacology and Toxicology

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Allium sativum is cultivated in the northern part of Ghana and has gained widespread use as chemoprotective, in curing hypertension, impotence and erectile dysfunction. The multipurpose use together with its aphrodisiac activity has resulted in the widespread use of this plant medicine both in meals and as herbal medications. Safety assessment of this plant however is rare. The present study is designed to evaluate the toxic effect of the aqueous extract of Allium sativa on the prostate, heart, liver kidney and haematological parameters after a shorterm administration in male-sprague-dawley rats. The following doses were used in different groups of male Sprague-Dawley Rats: 5000, 3000 and 1000 mg kg −1 . The following parameters were monitored: Clinical Chemistry, Gross and Histopathology (Heart, kidney, liver and prostate). No death was recorded at the highest dose of 5000 mg kg −1 . ASE reduced levels of urea and creatinine but increased levels of liver enzymes ALT, AST, ALP and bilirubin levels as compared to the controls. There was a statistically significant increase in WBC count (p<0.005) in all the doses except the median dose. There were no significant change in Red Blood Cell count (RBC) (p<0.003), Haemoglobin (HGB) (p<0.03), Haematocrit (HCT) p<0.0001), Mean Corpuscular Volume (MCV) Other parameters remained relatively unchanged. Gross pathology did not reveal any abnormality. Histopathological analysis showed that the extract did not have any adverse effect on the integrity of these organs. The results were within histopathological limits and did not reveal any abnormality in the examined organs namely: The prostate, kidney, liver and heart which maintained their integrity after the dose administration. Observations were within histopathological limits. ASE is reasonably safe when administered by the oral route within dosages of 1000-5000 mg kg −1 in Sprague dawley rats. This research has provided the safety implications as to the use of this plant.

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Section: Discussionsupporting

confidence: 84%

ABSENCE OF VISIBLE TOXIC EFFECTS ACCOMPANYING THE SHORT-TERM ADMINISTRATION OF AN AQUEOUS EXTRACT OF ALLIUM SATIVA LINN. IN MALE SPRAGUE-DAWLEY RATS

Isaac¹

2014

American Journal of Pharmacology and Toxicology

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“…However, the mechanisms underlying the anticancer effects of this class of compounds are not fully understood. Several mechanisms have been proposed, including antioxidant activity, tumor growth inhibition, effective stimulation of the immune response, and induction of apoptosis, which coincides with an increase in the percentage of cells blocked in the G2/M phase of the cell cycle [31].…”

Section: Allium Compoundsmentioning

confidence: 99%

Anticancer Mechanism of Sulfur-Containing Compounds

Gianni

Fimognari

2015

The Enzymes

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“…However the group that received 156 mg/kg of the extract also showed evidences of karyorrhexis. This is the fragmentation of the nucleus 22 . This result is similar to a previous report 12 .…”

Section: Discussionmentioning

confidence: 99%

“…This result is similar to a previous report 12 . Several investigations have shown that Allium sativum has deleterious effects on the cellular arrangement of various body parts including the prefrontal cortex, liver, kidney and heart 9,12 , as well as changes in the intestinal flora 7 , and induction of cell apoptosis 22 . However, it has also been reported that garlic prevents degeneration of the brain's frontal lobe and neuronal death in the hippocampus 3,4 , which may not be the case in the present study.…”

Section: Discussionmentioning

confidence: 99%

Chronic Allium sativum administration alters spontaneous alternation and cyto-architecture of medial prefrontal cortex of adult Wistar rats

Muonagolu¹,

Ekong²,

Edgaha³

2017

Internet Journal of Medical Update - EJOURNAL

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Intake of herbs and some of their constituents is reported to reduce risks of some diseases, with Allium sativum being one of such. This study was conducted to investigate the effects of Allium sativum extract on the medial prefrontal cortex and neurobehaviour of adult Wistar rats. Twenty-four male Wistar rats were divided into 4 groups (n = 6). Group 1 was the control and received distilled water placebo orally, while groups 2-4 received oral doses of 78 mg/kg, 156 mg/kg and 312 mg/kg Allium sativum extract for 28 days. On day 29, spontaneous alternation behavioural test was carried out, and immediately the rats were anaesthetized (50 mg/kg ketamine hydrochloride IP.) and perfusion-fixed with 10% buffered formalin. The whole brains were removed and the medial prefrontal cortex excised and processed for histomorphologic studies by haematoxylin and eosin, and cresyl fast violet techniques. Neurobehavioural test revealed less spontaneous alternation in 156 mg/kg Allium sativum group, while the prefrontal cortices of the test groups showed hypertrophy, hyperplasia, pyknosis, karyorrhexis, chromatolysis, loss of brain cellular membranes and Nissl substance. The 156 mg/kg Allium sativum group showed altered spontaneous alternation, while cellular pathologic changes were observed in the medial prefrontal cortex of these test groups in a dose dependent sequence.

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Eating garlic and onion: a matter of life or death

Cited by 18 publications

References 9 publications

ABSENCE OF VISIBLE TOXIC EFFECTS ACCOMPANYING THE SHORT-TERM ADMINISTRATION OF AN AQUEOUS EXTRACT OF <i>ALLIUM SATIVA</i> LINN. IN MALE SPRAGUE-DAWLEY RATS

ABSENCE OF VISIBLE TOXIC EFFECTS ACCOMPANYING THE SHORT-TERM ADMINISTRATION OF AN AQUEOUS EXTRACT OF <i>ALLIUM SATIVA</i> LINN. IN MALE SPRAGUE-DAWLEY RATS

Anticancer Mechanism of Sulfur-Containing Compounds

Chronic <i>Allium sativum</i> administration alters spontaneous alternation and cyto-architecture of medial prefrontal cortex of adult Wistar rats

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