Eating and drinking cause increased dopamine release in the nucleus accumbens and ventral tegmental area in the rat: Measurement by in vivo microdialysis

Yoshida, Masami; Yokoo, Hideyasu; Mizoguchi, Katsuhiro; Kawahara, Hiroshi; Tsuda, Atsushi; Nishikawa, Tadashi; Tanaka, Masatoshi

doi:10.1016/0304-3940(92)90861-z

Cited by 161 publications

(82 citation statements)

References 15 publications

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“…The DA system in the CNS is influenced by ingestive behaviors, body weight, and HFD (22,32,46) and is known to influence locomotor activity (44). However, no significant differences in DA were found after 48 h on WD in prefrontal cortex, ventral tegmental area, nucleus accumbens, or stratum, parts of the CNS that are suggested to be important for the DA effects on reward and locomotor activity (44).…”

Section: Discussionmentioning

confidence: 99%

Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice

Bjursell¹,

Gerdin²,

Lelliott³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

117

103

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The aim of the present study was to investigate the short- and long-term effects of a high-fat Western diet (WD) on intake, storage, expenditure, and fecal loss of energy as well as effects on locomotor activity and thermogenesis. WD for only 24 h resulted in a marked physiological shift in energy homeostasis, including increased body weight gain, body fat, and energy expenditure (EE) but an acutely lowered locomotor activity. The acute reduction in locomotor activity was observed after only 3–5 h on WD. The energy intake and energy absorption were increased during the first 24 h, lower after 72 h, and normalized between 7 and 14 days on WD compared with mice given chow diet. Core body temperature and EE was increased between 48 and 72 h but normalized after 21 days on WD. These changes paralleled plasma T3 levels and uncoupling protein-1 expression in brown adipose tissue. After 21 days of WD, energy intake and absorption, EE, and body temperature were normalized. In contrast, the locomotor activity was reduced and body weight gain was increased over the entire 21-day study period on WD. Calculations based on the correlation between locomotor activity and EE in 2-h intervals at days 21–23 indicated that a large portion of the higher body weight gain in the WD group could be attributed to the reduced locomotor activity. In summary, an acute and persisting decrease in locomotor activity is most important for the effect of WD on body weight gain and obesity in mice.

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Section: Discussionmentioning

confidence: 99%

Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice

Bjursell¹,

Gerdin²,

Lelliott³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

117

103

View full text Add to dashboard Cite

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“…Converging evidence prompts an interpretation of mesocorticolimbic DA as a more integrative system, although the 10 -20 min sampling periods for neurotransmitter measurement cannot match the rapid bursts of behavioral acts. For example, increases in accumbal DA have been measured during foraging or the initiation of feeding bouts (Hernandez and Hoebel, 1988;Yoshida et al, 1992;Westerink et al, 1994;Feenstra and Botterblom, 1996) or in the appetitive as well as consummatory phases of copulatory activity (Pfaus et al, 1990;Damsma et al, 1992;Mas et al, 1995;Pfaus et al, 1995;Sato et al, 1995). Importantly, DA changes have been measured after both socially rewarding and aversive events (Mos and van Valkenburg, 1979;Tizabi et al, 1980;Louilot et al, 1986;Haney et al, 1990;Mas et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

Aggressive Behavior, Increased Accumbal Dopamine, and Decreased Cortical Serotonin in Rats

2000

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Dopamine (DA) and serotonin have been implicated in the regulation of aggressive behavior, but it has remained challenging to assess the dynamic changes in these neurotransmitters while aggressive behavior is in progress. The objective of this study was to learn about ongoing monoamine activity in corticolimbic areas during aggressive confrontations in rats. Male Long-Evans rats were implanted with a microdialysis probe aimed at the nucleus accumbens (NAC) or medial prefrontal cortex (PFC); next, 10 min samples were collected before, during, and after a 10 min confrontation. Rats continued to display aggressive behavior while being sampled, and they performed two to six attack bites as well as 140 sec of aggressive acts and postures. Dopamine levels in NAC were significantly increased up to 60 min after the confrontation. Peak levels of 140% were achieved ϳ20-30 min after the confrontation. No concurrent changes in accumbal serotonin levels were seen during or after the confrontation. Dopamine and serotonin levels in PFC changed in the opposite direction, with a sustained decrease in serotonin to 80% of baseline levels during and after the confrontation and an increase in dopamine to 120% after the confrontation. The temporal pattern of monoamine changes, which followed rather than preceded the confrontation, points to a significant role of accumbal and cortical DA and 5-hydroxytryptamine in the consequences as opposed to the triggering of aggressive acts. The increase in accumbal DA in aggressive animals supports the hypothesis that this neural system is linked to the execution of biologically salient and demanding behavior. Key words: aggression; dopamine; serotonin; nucleus accumbens; prefrontal cortex; rats; microdialysis; behaviorThe proposal of a deficit in brain serotonin [5-hydroxytryptamine (5-HT)] as a trait marker for violence-prone individuals is based on measurements that are divorced from the actual behavioral event (Mann et al., 1995;Mann, 1999). In such individuals, low levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) were measured in CSF compared with nonviolent controls (Brown et al., 1982;Linnoila et al., 1983;Kruesi et al., 1990;Coccaro, 1992;Virkkunen et al., 1996;Kavoussi et al., 1997). In juvenile monkeys, low levels of 5-HIAA are correlated with increased risk-taking and impulsivity (Higley et al., 1992(Higley et al., , 1996Mehlman et al., 1994). If 5-HT undergoes dynamic state changes (Jacobs and Fornal, 1999) then in vivo measures would indicate whether altered serotonin actually is linked to the occurrence of episodes of aggression.In rodents, aggressive behavior is effectively reduced by treatment with 5-HT 1A and 5-HT 1B receptor agonists (Olivier and Mos, 1986;Olivier et al., 1987;De Almeida and Lucion, 1997;Simon et al., 1998;de Boer et al., 1999;Ferris et al., 1999;Fish et al., 1999). Furthermore, aggression is increased in 5-HT 1B receptor knock-out mice (Saudou et al., 1994). 5-HT modulates aggressive behavior in interaction with other neurotransmitters, of...

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“…Physiological state (e.g., hunger, thirst) seems to be a major determinant of this responsiveness (Church et al, 1987;Hernandez and Hoebel, 1988a,b;Radhakishun et al, 1988;Yoshida et al, 1992;Young et al, 1992;Inoue et al, 1993;Westerink et al, 1994;Wilson et al, 1995). However, because physiological need states are known to result in a generalized increase of the impact of motivational stimuli, including those unrelated to the deprived reward (Bindra, 1968), the specificity of these effects is unclear.…”

Section: Abstract: Da; Nucleus Accumbens; Prefrontal Cortex; Feedingmentioning

confidence: 99%

Differential Influence of Associative and Nonassociative Learning Mechanisms on the Responsiveness of Prefrontal and Accumbal Dopamine Transmission to Food Stimuli in Rats FedAd Libitum

1997

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Feeding a novel food (Fonzies) to rats fed ad libitum with standard food increased extracellular dopamine (DA) in the medial prefrontal cortex (PFCX) and in the medial nucleus accumbens (NAc). Previous Fonzies feeding, although it did not affect the increase of extracellular DA in the PFCX in response to Fonzies feeding, blunted that increase in the NAc (habituation); recovery from habituation in the NAc was complete 5 d after previous Fonzies feeding. Predictive association of an otherwise neutral stimulus extrinsic to Fonzies (empty plastic box) with Fonzies feeding resulted in the acquisition by the stimulus of the property to elicit incentive responses directed toward the stimulus and to increase extracellular DA in the PFCX. However, the same stimulus, or a more complex stimulus including intrinsic stimuli (Fonzies-filled plastic box), failed to acquire the ability to modify extracellular DA in the NAc.Pseudoconditioning, i.e., nonpredictive association of the extrinsic stimulus (empty box) with Fonzies feeding, did not result in acquisition by the stimulus of the property to elicit incentive responses and to increase extracellular DA in the PFCX. Repeated nonreinforced presentation of previously conditioned extrinsic stimuli (empty box) resulted in extinction of the property to elicit incentive responses and to increase extracellular DA in the PFCX. These results indicate that in rats fed ad libitum, phasic activation of mesocortical and mesolimbic DA systems by motivational stimuli is differentially influenced by associative (conditioning) and nonassociative (habituation) learning mechanisms and is differentially related to acquisition and expression of incentive motivation.

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Eating and drinking cause increased dopamine release in the nucleus accumbens and ventral tegmental area in the rat: Measurement by in vivo microdialysis

Cited by 161 publications

References 15 publications

Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice

Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice

Aggressive Behavior, Increased Accumbal Dopamine, and Decreased Cortical Serotonin in Rats

Differential Influence of Associative and Nonassociative Learning Mechanisms on the Responsiveness of Prefrontal and Accumbal Dopamine Transmission to Food Stimuli in Rats FedAd Libitum

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