EatA,a non-classical virulence factor,of Enterotoxigenic Escherichia coli (ETEC) is modulated by the host factors during pathogenesis

Bhakat, D.; Mondal, Indranil; Chatterjee, Nando K.

doi:10.1016/j.ijid.2020.09.048

Cited by 4 publications

(2 citation statements)

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“…Colonization plays a fundamental role in the initial step of the pathogenesis mechanism of ETEC. ETEC engage with small bowel epithelial cells by various plasmid-encoded colonization factor (CFs) genes encoding fimbrial, non-fimbrial and fibrillar structures [ 59 ]. Among many CFs, CFA/I, CFA/II, and CFA/IV are the main factors to mediate the colonization of ETEC and have been highly detected in ETEC isolated from clinical samples.…”

Section: Enterotoxigenic Escherichia Coli (Etec)mentioning

confidence: 99%

Virulence Factors of Enteric Pathogenic Escherichia coli: A Review

Pakbin

Brück²,

Rossen

2021

IJMS

139

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Escherichia coli are remarkably versatile microorganisms and important members of the normal intestinal microbiota of humans and animals. This harmless commensal organism can acquire a mixture of comprehensive mobile genetic elements that contain genes encoding virulence factors, becoming an emerging human pathogen capable of causing a broad spectrum of intestinal and extraintestinal diseases. Nine definite enteric E. coli pathotypes have been well characterized, causing diseases ranging from various gastrointestinal disorders to urinary tract infections. These pathotypes employ many virulence factors and effectors subverting the functions of host cells to mediate their virulence and pathogenesis. This review summarizes new developments in our understanding of diverse virulence factors associated with encoding genes used by different pathotypes of enteric pathogenic E. coli to cause intestinal and extraintestinal diseases in humans.

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Section: Enterotoxigenic Escherichia Coli (Etec)mentioning

confidence: 99%

Virulence Factors of Enteric Pathogenic Escherichia coli: A Review

Pakbin

Brück²,

Rossen

2021

IJMS

139

View full text Add to dashboard Cite

show abstract

“…Colonization plays a fundamental role in the initial step of the pathogenesis mechanism of ETEC. ETEC engage with small bowel epithelial cells by various plasmid-encoded colonization factor (CFs) genes encoding fimbrial, non-fimbrial and fibrillar structures [59]. Among many CFs, CFA/I, CFA/II and CFA/IV are the main factors to mediate colonization of ETEC and have highly been detected in ETEC isolated from clinical samples.…”

Section: Enterotoxigenic Escherichia Coli (Etec)mentioning

confidence: 99%

Virulence factors of Enteric Pathogenic Escherichia coli: A Review

Pakbin¹,

Brück²,

Rossen³

2021

Preprint

View full text Add to dashboard Cite

Escherichia coli are remarkably versatile microorganisms and important members of the normal intestinal microbiota of humans and animals. This harmless commensal organism can acquire a mixture of comprehensive mobile genetic elements that contain genes encoding viru-lence factors, becoming an emerging human pathogen capable of causing a broad spectrum of intestinal and extraintestinal diseases. Nine definite enteric E. coli pathotypes have been well characterized, causing diseases ranging from various gastrointestinal disorders to urinary tract infections. These pathotypes employ many virulence factors and effectors subverting the func-tions of host cells to mediate its virulence and pathogenesis. This review summarizes new de-velopments in our understanding of diverse virulence factors associated encoding genes used by different pathotypes of enteric pathogenic E. coli to cause intestinal and extraintestinal diseases in humans.

show abstract