Easy removal of pressure sensitive adhesives for skin applications

Chivers, Robin A.

doi:10.1016/s0143-7496(01)00015-x

Cited by 72 publications

(34 citation statements)

References 13 publications

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“…Human skin has a complex texture with viscoelasticity; pig skin resembles these properties, thus we performed peel test on pig skins [37]. In figure 2, the mean strength for Silbione® RT 4717 was greater than those of Silbione® RT 4642 and Silpuran® 2130, and statistic results were significant for the two comparisons (Silbione® RT 4717 and Silbione® RT 4642; Silbione® RT 4717 and Silpuran® 2130).…”

Section: Discussionmentioning

confidence: 99%

Silicone-based adhesives for long-term skin application: cleaning protocols and their effect on peel strength

Liu

Kuffel

Scott

et al. 2017

Biomed. Phys. Eng. Express

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Adhesives that involve adhesion to the skin have been of great technological importance in medical or pharmaceutical fields, including recently emerging wearable sensors and electronics. The objective of this work was to evaluate the performances of silicone-based adhesives with skin, using a peel adhesion test. Specifically, we explored the effect of adhesive cleansing, which is an inevitable daily event for patients' comfort in long-term applications. Firstly, three medical grade silicone gels, Silbione® RT 4717, Silbione® RT 4642, and Silpuran® 2130, were used to fabricate adhesive pads. Their peel strength values were subsequently measured and compared, among which Silbione® RT gel 4717 possessed the highest peel strength. Therefore, it was selected as the raw material to fabricate the pads with a thickness range of 640-740 μm. Secondly, the peel adhesion of Silbione® RT 4717 adhesive pad was further compared with a series of commercial products that employ various medical-grade adhesives. The peel strength results indicated that our custom-made adhesive pad had an adequately strong adhesion for clinical use. Thirdly, in order to observe and predict the long-term performance of the adhesives, an aging test was performed in an ambient environment, revealing that Silbione® RT 4717 adhesive remained highly sticky for 5 days. Lastly, adequate cleansing protocols were established by monitoring the changes in peel strength after washing and wiping events. The reusability analysis showed that Silbione® 4717 adhesive pad was reusable in a one-week period for the washing method and 3 days for the wiping method.

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Section: Discussionmentioning

confidence: 99%

Silicone-based adhesives for long-term skin application: cleaning protocols and their effect on peel strength

Liu

Kuffel

Scott

et al. 2017

Biomed. Phys. Eng. Express

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“…The work expended in the patch detachment includes the adherend deformation, other than the surfaces separation, adhesive layer deformation, and patch stretching and bending. The force required to achieve the maximum extension, which is generally quite low (1.7 N), depends on the peel contact angle [76]. The production of a substrate with a Young's modulus (about 7 --10 kPa) [77] close to that of human skin would better discriminate patch performances including the adhesive/ cohesive shift as a function of peel rate and application time [70].…”

Section: Prediction Of Patch In Vivo Adhesive Performancesmentioning

confidence: 99%

Adhesive properties: a critical issue in transdermal patch development

Cilurzo

Gennari

Minghetti

2011

Expert Opinion on Drug Delivery

112

113

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“…The results reported in Table 2 show very weak adhesion energies, comparable to those obtained in the first series of measurement (included between 0.9 and 9 J.m -2 ). Adhesion energy developed for assemblies of polymer parts with domestic glues can hold several 10 J.m -2 , for industrial joints between structural metal parts with a technical adhesive may reach several hundred of J.m -2 , and adhesion energy on the human skin ranges from 50 to 500 J.m -2 [13,14]. However, the comparison between these values and our results should be consider with precaution because the value of adhesion energy is test dependent and the mechanical properties of the substrate affect largely the value of the adhesion energy particularly for viscoelastic ones (dependence with peeling rate for example).…”

Section: Discussionmentioning

confidence: 99%

“…There are several medical fields that have successfully implemented powerful and helpful bondings on biological tissues. The adhesion on the human skin has been largely studied to improve wound dressings and especially their ability to well stuck on human skin and detached itself without residues on the skin nor pain during the detachment [13,14]. The results of these authors show that the value of the adhesion energy range from 50 to 500 J.m -2 depending on the application and the type of adhesive.…”

Section: Introductionmentioning

confidence: 99%

Adhesion of surgical sealants used in cardiothoracic and vascular surgery

Perrin

Braccini

Bidan

et al. 2016

International Journal of Adhesion and Adhesives

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International audienceSurgical sealants are widely used in cardiothoracic and vascular surgery essentially for hemostasis and sealing. Their adhesive properties have mainly been studied by clinical experiments. The objective of this study is to measure adhesion of the three main types of surgical sealant used in cardiothoracic and vascular surgery under normalized realistic conditions. The bulge-and-blister test was used to quantify adhesive performances of three types of surgical adhesives: cyanoacrylates, polyethylene glycol (PEG), and aldehydes. Samples were composed of two circular layers of equine pericardium glued by the surgical sealant studied. Comparative adhesion testing was carried out in eight samples bonded with a Dermabond® (cyanoacrylate), five samples with Bioglue® (aldehyde), four samples with Coseal® (PEG), and thirteen samples bonded with an industrial cyanoacrylate. Scanning electron microscope (SEM) observations of cross-sections of samples glued by Dermabond® and environmental scanning electron microscopy (ESEM) images of samples composed of equine pericardium glued by Bioglue® were also performed. The average value of the adhesion energy is 2.3+/-1.5 J.m-2 for samples glued with Dermabond®, 6.04+/-1.61 J.m-2 with Bioglue®, 2.37+/-1.25 J m-2 with Coseal®, 3.74+/-1.33 J m-2 with the industrial cyanoacrylate glue in surgical conditions. SEM observations of cross-sections of samples glued by Dermabond® showed a failure at the interface between the glue and the pericardial layer. ESEM observations have revealed a majority of regions where the glue is not linked to the pericardium. Adhesive performance measurements and microscopy observations in surgical conditions show that surgical sealants adhesion is weak and explain their poor efficacy in clinical practice. To improve adhesion in the surgical field, we need to focus on achieving a better cohesion between the adhesive and the substrate by modifying conditions adhesive bonding and consequently tend toward cohesive failure

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Easy removal of pressure sensitive adhesives for skin applications

Cited by 72 publications

References 13 publications

Silicone-based adhesives for long-term skin application: cleaning protocols and their effect on peel strength

Silicone-based adhesives for long-term skin application: cleaning protocols and their effect on peel strength

Adhesive properties: a critical issue in transdermal patch development

Adhesion of surgical sealants used in cardiothoracic and vascular surgery

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