Eastman chemical company acetic anhydride process

Designing organometallic compounds for catalysis and therapy

“…Early candidates such as [Ru(CO) 3 (Gly)Cl] (2, CORM-3) 4 are being supplemented by CO complexes of Fe (3), Mn (4) 5 and Co (5) as well as boron precursors. A critical requirement is that the complexes are stable enough in the blood to be transported to their biological target and only then are triggered to release the CO.…”

“…For example, carbonyl complexes of Rh, Ir or Co are widely used as catalysts for the synthesis of basic organic compounds such as methanol or acetic acid. 2,3 Intriguingly, carbon monoxide is a natural metabolite in the body, arising from heme metabolism, and also (along with NO, e.g. in 1 Figure 1) is an important signalling molecule.…”

Heck Reaction—State of the Art

“…In addition to Naproxen 138, Prosulfuron 139 and divinyltetramethyldisiloxane-bisbenzocyclobutene 141, use of Heck reaction in the synthesis of L-699,392 142, resveratrol 143, eletriptan 144, cincalcet 145 and montelukast sodium (Salt of Singulair) 146 (Figure 21) by different industries are discussed. A review by Zapf and Beller [79] published in succeeding year gives the importance of several palladium-catalysed reactions like Heck, Suzuki, Sonogashira, telomerization [80] and carbonylation [81], developed and optimized to a stage that enables application on an industrial scale. In addition to Naproxen 138, Prosulfuron 139 and divinyltetramethyldisiloxane-bisbenzocyclobutene 141, use of Heck reaction in the synthesis of L-699,392 142, resveratrol 143, eletriptan 144, cincalcet 145 and montelukast sodium (Salt of Singulair) 146 (Figure 21) by different industries are discussed.…”

Carbon Monoxide as a Chemical Feedstock: Carbonylation Catalysis

“…In the absence of water, added H 2 could also perform this role, as it does in the related Eastman acetic anhydride process [90,91].…”