Eastern diet and benign prostatic hyperplasia

Cho, Ahra; Eidelberg, Andrew; Chughtai, Bilal

doi:10.1016/b978-0-12-819765-3.00002-9

Cited by 2 publications

(5 citation statements)

References 50 publications

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“…While diet has become a focus to enhance human health, the attention on what types of diets yield the best outcomes is paramount from the perspective of consumers. The “Mediterranean or Eastern” diets versus a “Western diet” have gained popularity and promise not only for the management of LUTS/BPH, but to increase the general health status and well-being to address many other diseases and disorders [ 60 , 61 , 62 , 63 , 64 ]. For example, the Mediterranean diet is one of the most widely described and evaluated dietary patterns in scientific literature [ 61 ].…”

Section: Factors Influencing Bphmentioning

confidence: 99%

“…Additionally, the Eastern diet includes foods that contain β-carotene, vitamin C and, vitamin E found in vegetables, fish/seafood, lycopene found in tomatoes, and polyphenols/isoflavones found in legumes (beans, soy, etc.) [ 64 ]. Conversely, the Western diet contains refined carbohydrates, red meat, processed meats, fats/lipids/cholesterol, prevalent in high-income countries, which increase sympathetic nervous system, oxidative stress, and inflammation and low intake of fruits and vegetables [ 60 , 61 , 62 , 63 , 64 , 65 ] ( Figure 4 ).…”

Section: Factors Influencing Bphmentioning

confidence: 99%

“…[ 64 ]. Conversely, the Western diet contains refined carbohydrates, red meat, processed meats, fats/lipids/cholesterol, prevalent in high-income countries, which increase sympathetic nervous system, oxidative stress, and inflammation and low intake of fruits and vegetables [ 60 , 61 , 62 , 63 , 64 , 65 ] ( Figure 4 ). Additionally, shown in Figure 4 are the relative levels of physical activity associated among the three diets.…”

Section: Factors Influencing Bphmentioning

confidence: 99%

“…From these various reviews, the risk factors for BPH include (a) age [ 60 , 65 , 66 , 69 ], (b) smoking (vaping) [ 69 ], (c) obesity/overweight [ 69 , 72 ], (d) ↑ insulin [ 34 , 52 , 53 , 57 , 61 , 69 ], (e) ↑ lipids [ 61 , 69 , 72 ], (f) diabetes [ 33 , 35 , 69 ], (g) hypertension [ 53 , 69 ], and (h) depression [ 69 ]. Conversely, vitamins A, C, D and E are associated with decreased BPH symptoms [ 59 , 64 , 67 , 69 , 70 , 71 , 72 ]. Among the vitamins, D appeared to have the greatest impact on BPH followed by vitamins C, E, and then, A [ 64 , 69 , 72 ].…”

Section: Factors Influencing Bphmentioning

confidence: 99%

“…Conversely, vitamins A, C, D and E are associated with decreased BPH symptoms [ 59 , 64 , 67 , 69 , 70 , 71 , 72 ]. Among the vitamins, D appeared to have the greatest impact on BPH followed by vitamins C, E, and then, A [ 64 , 69 , 72 ]. This was especially the case with vitamin D deficiency, where prostatic inflammation was associated with the activation of the NFkβ, IL-6, and STAT3 pro-inflammatory pathways [ 70 ].…”

Section: Factors Influencing Bphmentioning

confidence: 99%

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Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome

Stewart

Lephart

2023

IJMS

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Benign prostatic hyperplasia (BPH) is an age-related disorder, which is one of the most prevalent and costly benign neoplasms in men with over 94 million cases worldwide. Starting before or around 50 years of age, there is a linear increase in prostate volume and BPH symptoms, which are influenced by changes in hormonal, inflammatory, growth factors, cell receptor signaling, diet, physical activity, and the microbiome of the prostate that leads to cellular proliferation. While current pharmaceutical or surgical treatments are currently available, each treatment has serious side effects. This dilemma has motived men to seek treatment without negative side effects from medicinal plants such as botanicals, phytochemicals, and vitamins that have established safety records. This narrative overview focuses on several botanicals, phytochemicals and vitamins that are widely used in the treatment of BPH and emphasizes how, in some cases, combinations of these natural ingredients may provide better BPH symptom relief compared to utilization of a single medicinal plant product (monotherapy). Finally, this overview highlights in vitro, in vivo animal studies and mainly clinical data of journal reports published in the past 5 years from January 2018 to January 2023 on BPH and nutraceuticals. Notably, there is an evolving perspective or rethinking of the role that medicinal phytochemicals and natural vitamins usage play; that is, they may hold promise or are likely to alleviate BPH symptoms.

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Section: Factors Influencing Bphmentioning

confidence: 99%

Section: Factors Influencing Bphmentioning

confidence: 99%

Section: Factors Influencing Bphmentioning

confidence: 99%

Section: Factors Influencing Bphmentioning

confidence: 99%

Section: Factors Influencing Bphmentioning

confidence: 99%

See 3 more Smart Citations

Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome

Stewart

Lephart

2023

IJMS

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Role of Phytotherapy in the Management of BPH: A Summary of the Literature

Antoniou

Gauhar

Modi

et al. 2023

JCM

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Benign prostatic hyperplasia (BPH) describes the non-malignant enlargement of the prostate. It is both common and growing in incidence. Treatment is multimodal, involving conservative, medical, and surgical interventions. This review aims to examine the evidence base for phytotherapies, specifically analyzing their role in treating lower urinary tract symptoms (LUTS) attributable to BPH. A literature search was completed, specifically looking for randomized control trials (RCTs) and systematic reviews involving phytotherapy treating BPH. Specific emphasis was placed on exploring substance origin, the proposed mechanism of action, evidence of efficacy, and the side-effect profile. Several phytotherapeutic agents were evaluated. These included serenoa repens, cucurbita pepo, and pygeum Africanum, among others. For most of the reviewed substances, only modest effectiveness was reported. Generally, though, all treatments were tolerated well with minimal side effects. None of the treatments discussed in this paper form part of the recommended treatment algorithm in either European or American guidelines. We, therefore, conclude that phytotherapies, in the treatment of LUTS attributable to BPH, do provide a convenient option for patients, with minimal side effects. At present, however, the evidence for the usage of phytotherapy in BPH is inconclusive, with some agents having more backing than others. This remains an expansive field of urology whereby there is still more research to be done.

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Eastern diet and benign prostatic hyperplasia

Cited by 2 publications

References 50 publications

Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome

Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome

Role of Phytotherapy in the Management of BPH: A Summary of the Literature

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