East-West pathology agreement on precancerous liver lesions and early hepatocellular carcinoma

Desmet, Valeer

doi:10.1002/hep.22681

Cited by 46 publications

(30 citation statements)

References 50 publications

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“…Hepatocyte-specific, inducible inactivation of Trim24 revealed that it acts as a cell-autonomous tumor suppressor, maintaining the quiescent state of hepatocytes (18). Similarly to models of liver cancer development in humans, the development of HCC in Trim24 Ϫ/Ϫ mice is a multistage process, validating the utility of this mouse model for understanding basic mechanisms of hepatocarcinogenesis in humans (2,16,18,19). As soon as 3 weeks after birth, while hepatocytes are terminating their postnatal development and are entering into quiescence, the first manifestations of the disease, namely increased hepatocyte proliferation, could be observed in Trim24-deficient mice.…”

Section: Hepatocellular Carcinoma (Hcc)mentioning

confidence: 96%

Tripartite Motif 24 (Trim24/Tif1α) Tumor Suppressor Protein Is a Novel Negative Regulator of Interferon (IFN)/Signal Transducers and Activators of Transcription (STAT) Signaling Pathway Acting through Retinoic Acid Receptor α (Rarα) Inhibition

Tisserand¹,

Khetchoumian²,

Thibault

et al. 2011

Journal of Biological Chemistry

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Section: Hepatocellular Carcinoma (Hcc)mentioning

confidence: 96%

Tripartite Motif 24 (Trim24/Tif1α) Tumor Suppressor Protein Is a Novel Negative Regulator of Interferon (IFN)/Signal Transducers and Activators of Transcription (STAT) Signaling Pathway Acting through Retinoic Acid Receptor α (Rarα) Inhibition

Tisserand¹,

Khetchoumian²,

Thibault

et al. 2011

Journal of Biological Chemistry

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“…In Trim24 −∕− mice, HCC develops as a result of a reproducible multistage process that parallels human HCC (8). Increased hepatocyte proliferation is observed as soon as postnatal wk 3, when normal hepatocytes enter into quiescence (3).…”

mentioning

confidence: 99%

Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma

Herquel

Ouararhni

Khetchoumian

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

179

168

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TRIM24 (TIF1α), TRIM28 (TIF1β), and TRIM33 (TIF1γ) are three related cofactors belonging to the tripartite motif superfamily that interact with distinct transcription factors. TRIM24 interacts with the liganded retinoic acid (RA) receptor to repress its transcriptional activity. Germ line inactivation of TRIM24 in mice deregulates RA-signaling in hepatocytes leading to the development of hepatocellular carcinoma (HCC). Here we show that TRIM24 can be purified as at least two macromolecular complexes comprising either TRIM33 or TRIM33 and TRIM28. Somatic hepatocyte-specific inactivation of TRIM24, TRIM28, or TRIM33 all promote HCC in a cell-autonomous manner in mice. Moreover, HCC formation upon TRIM24 inactivation is strongly potentiated by further loss of TRIM33. These results demonstrate that the TIF1-related subfamily of TRIM proteins interact both physically and functionally to modulate HCC formation in mice.

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“…2). In early HCC with pathological HCC stromal invasion [4,5,6,7,8,9], OATP1B3 expression decreases, and EOB uptake is decreased, visualized as an area of low intensity in the hepatocyte phase of Gd-EOB-MRI. However, even in some early HCCs, the expression of OATP1B3 may be reduced or lost, similar to that of moderately to poorly differentiated HCC; therefore, these early HCCs may show hypointensity in images on the hepatocyte phase of Gd-EOB-MRI.…”

Section: Gd-eob-mri Findings In Dysplastic Nodules and Hcc According mentioning

confidence: 99%

“…In our experience, we have rarely encountered dysplastic nodules showing low intensity on Gd-EOB-DTPA hepatocyte phase in resected cases [10]. Pathological diagnosis by biopsy sample alone is often limited and may underestimate the pathology because it is difficult to diagnose biopsied specimens as early HCC, even by liver-specialized pathologists, because of possible sampling error problems, limitations of biopsy, or the lack of evidence for stromal invasion, even if atypical cells and atypical structures mimicking early HCC are noted [4,5,6,7,8,9]. Therefore, comparisons of pathological findings of resected specimens and Gd-EOB-DTPA MRI findings are essential.…”

Section: Gd-eob-mri Findings In Dysplastic Nodules and Hcc According mentioning

confidence: 99%

Will Gd-EOB-MRI Change the Diagnostic Algorithm in Hepatocellular Carcinoma?

Kudo¹

2010

Oncology

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A hepatocyte-specific contrast agent, gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), was approved in Japan in 2008. This contrast agent enhances the blood pool and also is hepatocyte specific: it is taken up by hepatocytes and excreted into the biliary tract. Approximately 50% of the administered dose of Gd-EOB-DTPA is taken up by normal hepatocytes and subsequently excreted into the biliary tract, while the remaining 50% is excreted via the kidney. Hepatocellular uptake is considered to represent passive diffusion mediated by organic anion transporter polypeptide 1 (OATP1), which is expressed on the hepatocyte membrane. Gd-EOB-DTPA-enhanced MRI may offer a breakthrough for the diagnosis of liver tumors, particularly early hepatocellular carcinoma (HCC). The differentiation of dysplastic nodules from early HCC has remained difficult, even for pathologists specialized in liver tumors, but Gd-EOB-DTPA MRI facilitates an objective diagnosis with accuracy close to that of HCC-specialized pathologists. In conclusion, Gd-EOB-DTPA MRI facilitates the diagnosis of hypervascular advanced HCC and the differentiation of early HCC and dysplastic nodules, which used to be difficult, even with CT during arterial portography, and offers a high accuracy rate. Thus, Gd-EOB-DTPA MRI will have a significant impact on diagnostic algorithm for HCC.

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East-West pathology agreement on precancerous liver lesions and early hepatocellular carcinoma

Cited by 46 publications

References 50 publications

Tripartite Motif 24 (Trim24/Tif1α) Tumor Suppressor Protein Is a Novel Negative Regulator of Interferon (IFN)/Signal Transducers and Activators of Transcription (STAT) Signaling Pathway Acting through Retinoic Acid Receptor α (Rarα) Inhibition

Tripartite Motif 24 (Trim24/Tif1α) Tumor Suppressor Protein Is a Novel Negative Regulator of Interferon (IFN)/Signal Transducers and Activators of Transcription (STAT) Signaling Pathway Acting through Retinoic Acid Receptor α (Rarα) Inhibition

Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma

Will Gd-EOB-MRI Change the Diagnostic Algorithm in Hepatocellular Carcinoma?

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