East of the Andes: The genetic profile of the Peruvian Amazon populations

Corcia, Tullia Di; Mellado, C Sanchez; Francia, T. J. Davila; Ferri, Gianmarco; Sarno, Stefania; Luiselli, Donata; Rickards, Olga

doi:10.1002/ajpa.23209

Cited by 13 publications

(25 citation statements)

References 47 publications

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“…Hints from uniparental markers suggested that some gene flow between the Andes and Amazon could have occurred (Barbieri et al. 2014; Di Corcia et al. 2017; Gómez-Carballa et al.…”

Section: Introductionmentioning

confidence: 99%

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Dissecting the Pre-Columbian Genomic Ancestry of Native Americans along the Andes–Amazonia Divide

Gnecchi‐Ruscone

Sarno

Fanti

et al. 2019

Molecular Biology and Evolution

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Extensive European and African admixture coupled with loss of Amerindian lineages makes the reconstruction of pre-Columbian history of Native Americans based on present-day genomes extremely challenging. Still open questions remain about the dispersals that occurred throughout the continent after the initial peopling from the Beringia, especially concerning the number and dynamics of diffusions into South America. Indeed, if environmental and historical factors contributed to shape distinct gene pools in the Andes and Amazonia, the origins of this East-West genetic structure and the extension of further interactions between populations residing along this divide are still not well understood. To this end, we generated new high-resolution genome-wide data for 229 individuals representative of one Central and ten South Amerindian ethnic groups from Mexico, Peru, Bolivia, and Argentina. Low levels of European and African admixture in the sampled individuals allowed the application of fine-scale haplotype-based methods and demographic modeling approaches. These analyses revealed highly specific Native American genetic ancestries and great intragroup homogeneity, along with limited traces of gene flow mainly from the Andes into Peruvian Amazonians. Substantial amount of genetic drift differentially experienced by the considered populations underlined distinct patterns of recent inbreeding or prolonged isolation. Overall, our results support the hypothesis that all non-Andean South Americans are compatible with descending from a common lineage, while we found low support for common Mesoamerican ancestors of both Andeans and other South American groups. These findings suggest extensive back-migrations into Central America from non-Andean sources or conceal distinct peopling events into the Southern Continent.

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“…Hints from uniparental markers suggested that some gene flow between the Andes and Amazon could have occurred (Barbieri et al. 2014; Di Corcia et al. 2017; Gómez-Carballa et al.…”

Section: Introductionmentioning

confidence: 99%

“…Taking advantage from samples previously typed for uniparental markers, we generated new genomic data for five ethnic groups from Peruvian Amazon (Barbieri et al. 2014; Di Corcia et al. 2017), one group from the Gran Chaco region (Sevini et al.…”

Section: Introductionmentioning

confidence: 99%

Dissecting the Pre-Columbian Genomic Ancestry of Native Americans along the Andes–Amazonia Divide

Gnecchi‐Ruscone

Sarno

Fanti

et al. 2019

Molecular Biology and Evolution

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“…The results of clustering of STR profiles obtained by DAPC were compared with those from mtDNA analysis. mtDNAs of 132 urban Peruvian and 10 Moche individuals were newly genotyped, while the haplotypes of the remaining 90 Native Amazons were already available [ 15 ]. In S1 Table , for each subject, the variants of mtDNA HVS-I, HVS-II and coding regions are listed, along with the haplogroup and STR cluster affiliations.…”

Section: Resultsmentioning

confidence: 99%

“…The mtDNA of 132 urban Peruvian samples and 10 Native Amazon individuals belonging to Moche population were analyzed by sequencing, while mtDNA haplotypes of the other Native individuals were already published [ 15 ]. The amplification of the first and second hypervariable segments (HVS-I and HVS-II) of the mtDNA control region was carried out in a 25 μl reaction volume under standard conditions [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

“…Color shades from bright red to black refer to position on dimension 2. The references of all samples were reported: UrbanPeru (this paper); NCAndePeru [ 48 ] (this paper); AmazonPeru [ 15 , 17 ]; LaPazBolivia [ 61 ]; LlandosBolivia [ 61 ]; SubAndeBolivia [ 61 ]; TiticacaPeru [ 16 , 48 ]; AmazonBrazil [ 65 ]; TemucoChile [ 62 ]; SantiagoChile [ 62 ], PuntaArenas [ 62 ], IquiqueChile [ 62 ], ConceptionChile [ 62 ], NativesSArgentinaChile [ 66 , 67 ].…”

Section: Supporting Informationmentioning

confidence: 99%

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Signs of continental ancestry in urban populations of Peru through autosomal STR loci and mitochondrial DNA typing

et al. 2018

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The human genetic diversity around the world was studied through several high variable genetic markers. In South America the demic consequences of admixture events between Native people, European colonists and African slaves have been displayed by uniparental markers variability. The mitochondrial DNA (mtDNA) has been the most widely used genetic marker for studying American mixed populations, although nuclear markers, such as microsatellite loci (STRs) commonly used in forensic science, showed to be genetically and geographically structured. In this work, we analyzed DNA from buccal swab samples of 296 individuals across Peru: 156 Native Amazons (Ashaninka, Cashibo and Shipibo from Ucayali, Huambiza from Loreto and Moche from Lambayeque) and 140 urban Peruvians from Lima and other 33 urban areas. The aim was to evaluate, through STRs and mtDNA variability, recent migrations in urban Peruvian populations and to gain more information about their continental ancestry. STR data highlighted that most individuals (67%) of the urban Peruvian sample have a strong similarity to the Amazon Native population, whereas 22% have similarity to African populations and only ~1% to European populations. Also the maternally-transmitted mtDNA confirmed the strong Native contribution (~90% of Native American haplogroups) and the lower frequencies of African (~6%) and European (~3%) haplogroups. This study provides a detailed description of the urban Peruvian genetic structure and proposes forensic STRs as a useful tool for studying recent migrations, especially when coupled with mtDNA.

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Fine‐scale cultural variation reinforces genetic structure in England

Pichkar

Creanza

2023

American Journal of Biological Anthropology

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Objectives: Genes and languages both contain signatures of human evolution, population movement, and demographic history. Cultural traits like language are transmitted by interactions between people, and these traits influence how people interact. In particular, if groups of people differentiate each other based on some qualities of their cultures, and if these qualities are passed to the next generation, then this differentiation can result in barriers to gene flow. Previous work finds such barriers to gene flow between groups that speak different languages, and we explore this phenomenon further: can more subtle cultural differences also produce genetic structure in a population? We focus on whether subtle, dialect-level linguistic differences in England have influenced genetic population structure, likely by affecting mating preferences. Materials and Methods:We analyze spatially dense linguistic and genetic data-both of which independently contain spatially structured variation in England-to examine whether the cultural differences represented by variation in English phonology colocalize with higher genetic rates of change.Results: We find that genetic variation and dialect markers have similar spatial distributions on a country-wide scale, and that throughout England, linguistic boundaries colocalize with the boundaries of genetic clusters found using fineSTRUCTURE.Discussion: This gene-language covariation, in the absence of geographic barriers that could coordinate cultural and genetic differentiation, suggests that similar social forces influenced both dialect boundaries and the genetic population structure of England.

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East of the Andes: The genetic profile of the Peruvian Amazon populations

Cited by 13 publications

References 47 publications

Dissecting the Pre-Columbian Genomic Ancestry of Native Americans along the Andes–Amazonia Divide

Dissecting the Pre-Columbian Genomic Ancestry of Native Americans along the Andes–Amazonia Divide

Signs of continental ancestry in urban populations of Peru through autosomal STR loci and mitochondrial DNA typing

Fine‐scale cultural variation reinforces genetic structure in England

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