Easing the Journey—an Updated Review of Palliative Care for the Patient with High-Grade Glioma

Crooms, Rita C; Johnson, Margaret; Leeper, Heather; Mehta, Ankur; McWhirter, Michelle; Sharma, Akanksha

doi:10.1007/s11912-022-01210-6

Cited by 9 publications

(3 citation statements)

References 115 publications

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“…Patients with HGG experience highly intrusive symptoms, cognitive and functional decline, and emotional and existential distress throughout their disease trajectory [34]. Caregiver burden is also substantial with limited evidence to guide palliative management.…”

Section: Discussionmentioning

confidence: 99%

Short-course palliative hypofractionated radiotherapy in patients with poor-prognosis high-grade glioma: quality-of-life outcomes from a prospective phase II study

Baviskar

Likonda

Pant

et al. 2022

Preprint

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Purpose: To report longitudinal quality-of-life (QoL) outcomes in patients with poor prognosis high-grade glioma (HGG) treated with palliative hypofractionated radiotherapy (RT). Methods: Patients with poor-prognosis HGG based on age and performance status were accrued on a prospective study of short course palliative hypofractionated RT delivering 35Gy in 10 fractions over 2 weeks after written informed consent. European Organization for Research and Treatment of Cancer (EORTC) QoL core questionnaire (QLQ-C30) and brain cancer module (BN20) were used in English or validated Indian vernacular languages (Hindi and Marathi) for QoL assessment at baseline (pre-RT), conclusion of RT, 1-month post-RT and subsequently at 3-monthly intervals until disease progression/death. Summary QoL scores were compared longitudinally over time by related samples Friedman’s two-way test. Results: Forty-nine (89%) of 55 patients completed the planned course of hypofractionated RT. Longitudinal QoL data was available in 42 (86%) patients that constitutes the present study cohort. Median age of included patients comprising mainly of glioblastoma (81%) was 57 years with median baseline Karnofsky score of 60. Baseline QoL scores of included patients were significantly worse for several domains compared to historical institutional cohort of HGG patients treated previously with conventionally fractionated RT indicating negative selection bias. QoL scores remained stable for most domains after palliative hypofractionated RT with statistically significant improvements in fatigue (p=0.032), dyspnea (p=0.042) and motor dysfunction (p=0.036) over time. Conclusion: Short-course palliative hypofractionated RT in patients with poor-prognosis HGG is associated with stable and/or improved QoL scores in several domains making it a viable resource-sparing regimen.

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Section: Discussionmentioning

confidence: 99%

Short-course palliative hypofractionated radiotherapy in patients with poor-prognosis high-grade glioma: quality-of-life outcomes from a prospective phase II study

Baviskar

Likonda

Pant

et al. 2022

Preprint

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“…Malignant brain tumors [33][34][35][36][37] HGGs are the most common primary malignant brain tumors (80%).…”

Section: Table 4 Palliative Care Challenges and Management Of Maligna...mentioning

confidence: 99%

Palliative care in neurology patients

Hoda¹,

Bharati²

2023

International Anesthesiology Clinics

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“…'Spirituality is the dynamic dimension of human life that relates to the way persons (individual and community) experience, express and/or seek meaning, purpose and transcendence, and the way they connect to the moment, to self, to others, to nature, to the signi cant and/or the sacred.' [5] Current research [6][7][8][9][10][11][12][13] on the spiritual needs of neuro-oncological patients and health professionals' attitudes toward spiritual care in this highly specialized eld is limited. Spiritual care protocols for patientcentered care are lacking [11,14] and as brain tumor patients can suffer from rapid neurocognitive deterioration, patients' spiritual needs are often neglected [6].…”

Section: Introductionmentioning

confidence: 99%

‘Not me!’ a qualitative, vignette-based study of nurses’ and physicians’ reactions to spiritual distress on neuro-oncological units

Völz,

Grabenweger,

Best

et al. 2023

Preprint

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Purpose People with primary malignant brain tumors experience serious health-related suffering caused by limited prognosis and high symptom burden. The aim of this study was to analyze the attitudes and behavior of nurses and physicians when confronted with spiritual distress in these patients. Methods Neurospirit-DE is a qualitative vignette-based, multicentre, cross-sectional online survey that was conducted in Bavaria, Germany. Reflexive Thematic Analysis was used for data analysis. Results A total of 143 nurses and physicians working in neurological and neurosurgical wards in 46 hospitals participated in the survey. The participants questioned if the ability to provide spiritual care can be learned or is a natural skill. Spiritual care as a responsibility of the whole team was highlighted and the staff reflected on the appropriate way of involving spiritual care experts. The main limitations to spiritual care were a lack of time and not viewing spiritual engagement as part of the professional role. Some were able to personally benefit from spiritual conversations with patients, but many participants criticized the perceived emotional burden while expressing the imminent need for specific training and team reflection. Conclusions Most neuro-oncological nurses and physicians perceive spiritual care as part of their duty and know how to alleviate the patient’s spiritual distress. Nonetheless, validation of spiritual assessment tools for neuro-oncology and standardized documentation of patients' distress, shared interprofessional training, and reflection on the professional and personal challenges faced when confronted with spiritual care in neuro-oncology require further improvement.

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Easing the Journey—an Updated Review of Palliative Care for the Patient with High-Grade Glioma

Cited by 9 publications

References 115 publications

Short-course palliative hypofractionated radiotherapy in patients with poor-prognosis high-grade glioma: quality-of-life outcomes from a prospective phase II study

Short-course palliative hypofractionated radiotherapy in patients with poor-prognosis high-grade glioma: quality-of-life outcomes from a prospective phase II study

Palliative care in neurology patients

‘Not me!’ a qualitative, vignette-based study of nurses’ and physicians’ reactions to spiritual distress on neuro-oncological units

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