Easily-injectable shear-thinning hydrogel provides long-lasting submucosal barrier for gastrointestinal endoscopic surgery

Tang, Yutao; Hu, Minhui; Tang, Fuxin; Huang, Rongkang; Wang, Hui; Wu, Dingcai; Lan, Ping

doi:10.1016/j.bioactmat.2021.11.026

Cited by 14 publications

(11 citation statements)

References 57 publications

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“…BCCS 001 GH bacteria known as Pantoan. Generally speaking, bacterial EPS's such as cellulose, xanthan, levan, gellan-based hydrogels have already been applied for a number of tissue engineering applications [ 38 , 71 , 73 , 75 , [80] , [81] , [82] ]. They have indeed become highly sought out in the field due to their varied chemical and material properties, as they can become produced in mass at a very low-cost, while displaying unique viscoelastic and wettability suitable for hydrogel-based stem cell niches and advanced bioinks.…”

Section: Discussionmentioning

confidence: 99%

Enhancing volumetric muscle loss (VML) recovery in a rat model using super durable hydrogels derived from bacteria

Niknezhad,

Mehrali,

Khorasgani

et al. 2024

Bioactive Materials

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Section: Discussionmentioning

confidence: 99%

Enhancing volumetric muscle loss (VML) recovery in a rat model using super durable hydrogels derived from bacteria

Niknezhad,

Mehrali,

Khorasgani

et al. 2024

Bioactive Materials

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“…A small number of researchers have also begun to focus on the performance of shear-thinning materials for SIM ( Pang et al, 2019 ). Yan Pang et al have developed a shear-thinning hydrogel with low injection pressure and good elevation performance ( Tang et al, 2022 ), but the biocompatibility and maneuverability of shear-thinning materials are unknown.…”

Section: Introductionmentioning

confidence: 99%

Injectable temperature-sensitive hydrogel facilitating endoscopic submucosal dissection

Xu,

Yang,

et al. 2024

Front. Bioeng. Biotechnol.

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Purpose: Early gastrointestinal tumors can be removed by endoscopic procedures. Endoscopic mucosal dissection (ESD) requires submucosal fluid injection to provide mucosal elevation and prevent intraoperative perforation. However, the clinically applied normal saline mucosal elevation height is low for a short time, which often requires multiple intraoperative injections that increase the inconvenience and procedure time. In addition, recently researched submucosal injection materials (SIM) suffer from complex preparation, poor economy, and poor biocompatibility. Therefore, there is an urgent need for a new type of SIM that can provide long, safe and effective mucosal elevation in support of the endoscopic procedures.Methods: The FS hydrogel is based on polyethylene-polypropylene glycol (F-127) mixed with sodium alginate (SA). The different physicochemical properties of FS hydrogels were characterized through various experiments. Afterward, various biosafety assessments were carried out. Finally, the performance of FS hydrogels was evaluated by in vitro submucosal injection and in vivo swine ESD.Results: The experimental results show that the FS hydrogel is liquid at room temperature, making it easy to inject, and when injected under the mucosa, it undergoes temperature-induced cross-linking, transforming from a liquid to a solid state to provide long-lasting mucosal augmentation. At the same time, the FS hydrogel exhibits controllable gelation, stability, and biocompatibility. The results of in vitro submucosal injections and in vivo ESD procedures showed that FS achieves high mucosal augmentation and provides good submucosal cushioning in the long term.Conclusion: In summary, the F-127/SA hydrogel is simple to synthesize, cost-effective, safe, easy to store, and able to assist ESD well from the perspective of practical clinical problems, indicating that the FS hydrogel can be an ideal potent submucosal injection substitution.

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“…[1,6] However, obstruction of injection tools due to postponed operation or spread of the hydrogel to surrounding tissues of wounds would usually occur. [7] The shearthinning property of an injectable hydrogel may offer solutions to these issues, because it can improve the viscous flow of hydrogel mixture before injection and ensure hydrogel to be injected easily via a syringe. [7a] Further, rapid self-healing capability rendered by reversible dynamic bonds enables injectable hydrogels to autonomically restore their network structure after injection, prolonging their lifetime and improving their performance in biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Enteromorpha Prolifera Polysaccharide‐Derived Injectable Hydrogel for Fast Intraoperative Hemostasis and Accelerated Postsurgical Wound Healing Following Tumor Resection

Jiang,

Li,

Tian

et al. 2023

Adv Healthcare Materials

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Intraoperative bleeding and delayed postsurgical wound healing caused by persistent inflammation can increase the risk of tumor recurrence after surgical resection. To address these issues, Enteromorpha prolifera polysaccharide (PEP) with intrinsic potentials for hemostasis and wound healing, is chemically modified into aldehyde‐PEP and hydrazine‐PEP. Thereby, an injectable double‐network hydrogel (OPAB) is developed via forming dual dynamic bonding of acylhydrazone bonds between the decorated aldehyde and hydrazine groups and hydrogen bonds between hydroxyl groups between boric acid and PEP skeletons. The OPAB exhibits controllable shape‐adaptive gelation (35.0 s), suitable mechanical properties, nonstimulating self‐healing (60 s), good wet tissue adhesion (30.9 kPa), and pH‐responsive biodegradability. For in vivo models, owing to these properties, OPAB can achieve rapid hemostasis within 30 s for the liver hemorrhage, and readily loading of curcumin nanoparticles to remarkably accelerate surgical wound closure by alleviating inflammation, re‐epithelialization, granulation tissue formation, and collagen deposition. Overall, this multifunctional injectable hydrogel is a promising material that facilitates simultaneous intraoperative hemorrhage and postsurgical wound repair, holding significant potential in the clinical managements of bleeding and surgical wounds for tumor resection.

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Easily-injectable shear-thinning hydrogel provides long-lasting submucosal barrier for gastrointestinal endoscopic surgery

Cited by 14 publications

References 57 publications

Enhancing volumetric muscle loss (VML) recovery in a rat model using super durable hydrogels derived from bacteria

Enhancing volumetric muscle loss (VML) recovery in a rat model using super durable hydrogels derived from bacteria

Injectable temperature-sensitive hydrogel facilitating endoscopic submucosal dissection

Enteromorpha Prolifera Polysaccharide‐Derived Injectable Hydrogel for Fast Intraoperative Hemostasis and Accelerated Postsurgical Wound Healing Following Tumor Resection

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