Easily grafted polyurethanes with reactive main chain functional groups. Synthesis, characterization, and antithrombogenicity of poly(ethylene glycol)-grafted poly(urethanes)

Orban, Janine M.; Chapman, Toby M.; Wagner, William R.; Jankowski, Ron

doi:10.1002/(sici)1099-0518(19990901)37:17<3441::aid-pola1>3.0.co;2-y

Cited by 14 publications

(9 citation statements)

References 39 publications

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“…Other than polysaccharides, hydrophilic synthetic polymers, particularly PEG (Park et al, 1998;Orban et al, 1999; Chen et al, 2009;Rana et al, 2010), were also investigated as antifouling coatings for polyurethane-based medical devices. Although PEG possesses unique properties of nontoxicity and biocompatibility, the main limitation associated with its grafting to the polymer surface is the poor resistance to hydrolysis (Shen et al, 2002), a possible cause of coating detachment.…”

Section: Discussionmentioning

confidence: 99%

“…Notwithstanding the presence of soft domains that are hydrophilic and flexible, polyurethanes, if not properly functionalized, are not able to effectively counteract bacterial adhesion. Their coating or grafting with hydrophilic polymers is the most common strategy to improve their surface wettability (Orban et al, 1999;Sagnella & Mai-Ngam, 2005;Perrino et al, 2008;Chen et al, 2009;Rana et al, 2010) and thus their antiadhesive properties vs. bacteria (Park et al, 1998;Morra & Cassinelli, 1999). Overall, very few data are available on the ability of these functionalized polyurethanes to control microbial adhesion on and surface colonization of medical devices.…”

Section: Introductionmentioning

confidence: 99%

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Antifouling polyurethanes to fight device-related staphylococcal infections: synthesis, characterization, and antibiofilm efficacy

et al. 2014

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In hospital settings, biofilm-based medical device-related infections are considered a threat to patients, the sessile growing bacteria playing a key role in the spreading of healthcare-associated infections. In recent decades, the design of antifouling coatings for medical devices able to prevent microbial adhesiveness has emerged as one of the most promising strategies to face this important issue. In order to obtain suitable antifouling materials, segmented polyurethanes characterized by a hard/soft domain structure, having the same hard domain but a variable soft domain, have been synthesized. The soft domain was constituted by one of the following macrodiols: polypropylenoxide (PPO), polycaprolactide (PCL), and poly-l-lactide (PLA). The effects of the polymer hydrophilicity and the degree of hard/soft domain separation on antifouling properties of the synthesized polyurethanes were investigated. Microbial adherence assays evidenced as the polymers containing PCL or PLA were able to significantly reduce the adhesion of Staphylococcus epidermidis with respect to the PPO-containing polymer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antifouling polyurethanes to fight device-related staphylococcal infections: synthesis, characterization, and antibiofilm efficacy

et al. 2014

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“…Measurements of forces of interaction between bacteria and PEG chains anchored onto glass surfaces showed that PEG brushes not only blocked the long-range attractive forces, but also introduced repulsive steric effects between the bacteria and the substrate. Presumably, the repulsive forces resulted from the compression of the highly flexible PEG chains, which would involve the removal of water molecules from the hydrated polymer, and is not a thermodynamically favorable process [29].As for polyurethanes, PEG was either introduced in the backbone as a soft segment [30-32], or grafted in the polymer side chain [33,34]. Most of such PEG-containing PUs were studied in terms of bio-and hemo-compatibility properties, through the study of polymer affinity towards biomolecules such as albumin, fibrinogen, or heparin [35][36][37][38][39].…”

mentioning

confidence: 99%

Synthesis, Characterization, and Bacterial Fouling-Resistance Properties of Polyethylene Glycol-Grafted Polyurethane Elastomers

Francolini

Silvestro

Lisio

et al. 2019

IJMS

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Despite advances in material sciences and clinical procedures for surgical hygiene, medical device implantation still exposes patients to the risk of developing local or systemic infections. The development of efficacious antimicrobial/antifouling materials may help with addressing such an issue. In this framework, polyethylene glycol (PEG)-grafted segmented polyurethanes were synthesized, physico-chemically characterized, and evaluated with respect to their bacterial fouling-resistance properties. PEG grafting significantly altered the polymer bulk and surface properties. Specifically, the PEG-grafted polyurethanes possessed a more pronounced hard/soft phase segregated microstructure, which contributed to improving the mechanical resistance of the polymers. The better flexibility of the soft phase in the PEG-functionalized polyurethanes compared to the pristine polyurethane (PU) was presumably also responsible for the higher ability of the polymer to uptake water. Additionally, dynamic contact angle measurements evidenced phenomena of surface reorganization of the PEG-functionalized polyurethanes, presumably involving the exposition of the polar PEG chains towards water. As a consequence, Staphylococcus epidermidis initial adhesion onto the surface of the PEG-functionalized PU was essentially inhibited. That was not true for the pristine PU. Biofilm formation was also strongly reduced.

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“…The resulting residue was purified by SiO 2 column chromatography (EtOAc/MeOH (10:1)) to give 1 (28.1 g, 96%). 25 1 H NMR (270 MHz, CDCl 3 ) 3.84-3.72 (s, 4H, HO-…”

Section: Synthesis Of Axlementioning

confidence: 99%

Pseudorotaxane-coupled Gel: A New Concept of Interlocked Gel Synthesis by Using Metathesis Reaction

Yamabuki

Isobe

Onimura

et al. 2008

Polym J

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Easily grafted polyurethanes with reactive main chain functional groups. Synthesis, characterization, and antithrombogenicity of poly(ethylene glycol)-grafted poly(urethanes)

Cited by 14 publications

References 39 publications

Antifouling polyurethanes to fight device-related staphylococcal infections: synthesis, characterization, and antibiofilm efficacy

Antifouling polyurethanes to fight device-related staphylococcal infections: synthesis, characterization, and antibiofilm efficacy

Synthesis, Characterization, and Bacterial Fouling-Resistance Properties of Polyethylene Glycol-Grafted Polyurethane Elastomers

Pseudorotaxane-coupled Gel: A New Concept of Interlocked Gel Synthesis by Using Metathesis Reaction

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