Early β-hCG levels predict live birth after single embryo transfer

Hughes, Lydia; Schuler, Adrienne; Sharmuk, Maxwell; Schauer, Jacob M.; Pavone, Mary Ellen; Bernardi, Lia A.

doi:10.1007/s10815-022-02606-w

Cited by 6 publications

(7 citation statements)

References 40 publications

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“…In addition, they discovered that a postovulatory 14 th -day beta hCG level of 104.5 mIU/mL predicted a live birth with 80.3% sensitivity and 74.1% specificity. Hughes et al (21) discovered that when beta hCG levels "doubled" in 48 hours, a live birth occurred in 80.7% of IVF cycles, and when beta hCG levels "reached 100" 15 days after oocyte retrieval, a live birth occurred in 81.6% of IVF cycles. In this study, post-ET 14 th -day beta hCG was the most accurate predictor of live birth, with an optimal cut-off value of 216 IU/L.…”

Section: Discussionmentioning

confidence: 99%

The Role of Beta hCG Value Measured on the 12th and 14th Days After Embryo Transfer in Determining Early Complications of Pregnancy

Gök Korucu,

Aydın,

Günenc

et al. 2024

Düzce Tıp Fakültesi Dergisi

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Aim: This study aimed to investigate the role of beta human chorionic gonadotropin (beta hCG) levels on post embryo transfer (ET) 12th- and 14th-day, and its folding after 48 hours in predicting live birth, abortion, and biochemical pregnancy. Material and Methods: The study included 124 patients who had a positive pregnancy test after a fresh single day 3 ET at the in vitro fertilization (IVF) center between 2017 and 2021. The first beta hCG value was measured 12th day and the second 14th day after ET. The beta hCG fold was calculated by dividing the second beta hCG value by the first beta hCG value. Results: The patients' IVF indications included unexplained (n=40, 41.1%), poor ovarian reserve (n=23, 25.0%), male factor (n=31, 29.8%), and tubal factor (n=3, 4.1%). Of the 124 patients, 97 (78.2%) had a fetal sac, 81 (63.5%) had a fetal heartbeat (FHB), and 70 (56.5%) had a live birth. The results indicated that the post-ET 14th-day beta hCG level was the best predictor of biochemical pregnancy. It has a high sensitivity (92.5%) and specificity (86.6%), with an optimal cut-off value of 175 U/L. The post-ET 14th-day beta hCG level was the best predictor of a live birth. The post-ET 14th-day beta hCG value of 214.5 U/L had an 82.7% sensitivity and 74.4% specificity to predict the FHB. Conclusion: The beta hCG value, measured between the 12th and 14th days after ET, as well as the folding rate on these two days, can provide information about the pregnancy progression.

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Section: Discussionmentioning

confidence: 99%

The Role of Beta hCG Value Measured on the 12th and 14th Days After Embryo Transfer in Determining Early Complications of Pregnancy

Gök Korucu,

Aydın,

Günenc

et al. 2024

Düzce Tıp Fakültesi Dergisi

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“…However, this study involved the evaluation of embryos with and without of PGD. [9] Some studies have indicated that TB decreases initial β-hCG levels. Because all PGD embryos were frozen embryo transfers, the β-hCG value may have been lower in frozen embryo transfer cycles [19,20].…”

Section: Discussionmentioning

confidence: 99%

“…[15,16] Although there have been numerous studies on this topic, results regarding the day of β-hCG testing versus the day of embryo transfer are conflicting and unclear. [7,[9][10][11][17][18][19] Fertility centers may adhere to various procedures for initial β-hCG testing; however, the initial assessment of serum β-hCG levels is usually performed approximately 11 days after the transfer of cleavage-stage embryos or 9 days after blastocyst transfer. This timing corresponded to day 14 after oocyte retrieval.…”

Section: Discussionmentioning

confidence: 99%

“…[6] Several studies have reported various initial β-hCG threshold levels to explore the relationship between serum β-hCG levels and pregnancy outcomes. [7][8][9][10][11] However, a few of these studies have compared the β-hCG thresholds for predicting clinical outcomes in pregnancies conceived by the transfer of single fresh and frozen-thawed blastocyst-stage embryos and have revealed conflicting results.…”

Section: Introductionmentioning

confidence: 99%

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Initial β-hCG levels and 2-day-later increase rates effectively predict pregnancy outcomes in single blastocyst transfer in frozen-thawed or fresh cycles: A retrospective cohort study

Ozer

2023

Medicine

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To investigate whether the initial beta-human chorionic gonadotropin (β-hCG) levels and their rate of increase differ after single fresh and frozen blastocyst transfers, and whether these values effectively predict pregnancy outcomes. This retrospective cohort study was conducted at the Sisli Memorial Hospital, assisted reproductive technology, and Reproductive Genetics Center in Istanbul, Turkey, between January 2016 and January 2022. Three thousand two hundred thirty-eight single blastocyst transfers with positive pregnancy test results were evaluated. Of these, 738 were fresh transfer cycles and 2500 were frozen-thawed embryo transfer (FET) cycles. β-hCG test results from 9 days after fresh and FET cycles were compared between the groups with biochemical pregnancy, early pregnancy loss, and live birth outcomes. The threshold values were determined for each pregnancy outcome. The rate of increase between the first and second β-hCG tests performed 2 days apart was determined for each pregnancy outcome. Finally, the listed values were compared between the FET and fresh cycle. Mean baseline β-hCG levels were significantly higher in FET cycles than in fresh cycles, regardless of pregnancy outcomes (P < .005). Baseline β-hCG levels were higher in fresh cycles with live births (171.76 ± 109.64 IU/L) compared to biochemical and clinical pregnancy losses (50.37 ± 24.31 and 114.86 ± 72.42, respectively) (P < .001). Live births in FET cycles resulted in higher baseline β-hCG levels (193.57 ± 100.38 IU/L) compared to biochemical and clinical pregnancy loss groups (68.41 ± 51.85 and 149.29 ± 96.99 IU/L, respectively) (P < .001). The β-hCG threshold for live birth for fresh cycles was 116.5 IU/L (sensitivity 80%, specificity 70%, positive predictive value 90%, negative predictive value 54%) and 131.5 IU/L for FET cycles (sensitivity 71%, specificity 68%, positive predictive value 87%, negative predictive value 50%). The percentage of the area under the curve for single fresh blastocyst transfers was 0.81 and 0.76 for frozen transfers. The rate of increase in β-hCG was similar in fresh and FET cycles. Initial β-hCG levels and 2-day increases are effective parameters for diagnosing pregnancy in fresh and FET cycles. The initial β-hCG level was significantly higher in the FET cycles than in the fresh cycles. Predicting outcomes earlier helps clinicians to manage and follow high-risk pregnancies.

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“…Ultrasound and serial hCG levels are recommended for monitoring. An ectopic pregnancy may be considered when hCG levels are excessively high but cannot be confirmed in isolation [ [35] , [36] , [37] , [38] ]. Due to the presence of discriminating levels, extreme caution is warranted when ruling out an intrauterine pregnancy with rising hCG.…”

Section: Methodsmentioning

confidence: 99%

Liability, risks, and recommendations for ultrasound use in the diagnosis of obstetrics diseases

Sun,

Wu,

et al. 2023

Heliyon

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Early β-hCG levels predict live birth after single embryo transfer

Cited by 6 publications

References 40 publications

The Role of Beta hCG Value Measured on the 12th and 14th Days After Embryo Transfer in Determining Early Complications of Pregnancy

The Role of Beta hCG Value Measured on the 12th and 14th Days After Embryo Transfer in Determining Early Complications of Pregnancy

Initial β-hCG levels and 2-day-later increase rates effectively predict pregnancy outcomes in single blastocyst transfer in frozen-thawed or fresh cycles: A retrospective cohort study

Liability, risks, and recommendations for ultrasound use in the diagnosis of obstetrics diseases

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