Early Wound Healing Following One‐Stage Dental Implant Placement With and Without Antibiotic Prophylaxis: A Pilot Study

Khoury, Samer B.; Thomas, L. P.; Walters, John D.; Sheridan, John F.; Leblebicioğlu, Binnaz

doi:10.1902/jop.2008.070670

Cited by 37 publications

(58 citation statements)

References 46 publications

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“…The authors found low but measureable levels of proinflammatory cytokines in PICF after implant placement, which is consistent with previous data on inflammatory responses after implant placement 14,23,41 . Notably, the data of very low levels of IL‐8 and IL‐1α in PICF and GCF at the 1‐year follow‐up are in agreement with the findings of a previous report 34 showing low concentrations of IL‐1β in PICF.…”

Section: Discussionsupporting

confidence: 90%

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Longitudinal Comparison of Cytokines in Peri‐Implant Fluid and Gingival Crevicular Fluid in Healthy Mouths

Nogueira-Filho

Pesun

Isaak-Ploegman

et al. 2014

Journal of Periodontology

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Section: Discussionsupporting

confidence: 90%

“…A previous report showed that after a 21‐day period of de novo plaque formation, GCF and PICF volumes were increased; 40 in a separate study, PICF volume was increased after implant placement 41 . These data indicate that GCF and PICF volumes are related to the level of inflammation in gingival and peri‐implant tissues, respectively.…”

Section: Discussionmentioning

confidence: 55%

Longitudinal Comparison of Cytokines in Peri‐Implant Fluid and Gingival Crevicular Fluid in Healthy Mouths

Nogueira-Filho

Pesun

Isaak-Ploegman

et al. 2014

Journal of Periodontology

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“…One study has further recommended a single post-operative dose as well [14]. The concept of prolonged antimicrobial therapy has been questioned [30,[32][33][34][35][36][37]. Out of our respondents, 96.1 % (n = 273) recommended continuing prolonged therapy in a range of 3-10 days after surgery, findings similar to the trend seen by Abukaraky et al [31] in their Jordanian sample.…”

Section: Discussionsupporting

confidence: 66%

Current Trend of Antimicrobial Prescription for Oral Implant Surgery Among Dentists in India

Datta

Grewal

Batth

et al. 2013

J. Maxillofac. Oral Surg.

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Objectives The aim of our study was to evaluate antimicrobial prescription behaviour amongst dentists performing oral implant surgery in India. Study Design Dentists performing oral implant surgery from different parts of India were personally approached during various national events such as conferences and academic meetings and information regarding their prescription habits for antimicrobial agents in routine oral implant surgery was collected using a structured questionnaire. Results Out of a total sample of 332 dentists, 85.5 % prescribed 17 different groups or combinations of antibiotics routinely for oral implant surgery in the normal healthy patient. Majority preferred the peri-operative protocol of drug therapy (72.2 %) with variable and prolonged duration of therapy after surgery, ranging from 3 to 10 days. An antimicrobial mouthwash was routinely prescribed by all the doctors (14.5 %) not in favour of prescribing antimicrobials in a normal healthy patient.Conclusions Our findings suggest that there is a trend of antimicrobial agent misuse by dentists performing oral implant surgery in India, both in terms of drugs used and the protocols prescribed. The majority of these dentists prescribed a variety of antimicrobial agents for prolonged durations routinely even in the normal, healthy patients.

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“…Although this difference was not significant, it suggests that post‐surgical healing progressed more rapidly in the AZM group. The observed PICF volumes per 30‐second sample are comparable to those reported previously 26 , 28 . The data suggest that resolution of postoperative inflammation and healing of the junctional epithelium occurred more rapidly in the AZM group.…”

Section: Discussionsupporting

confidence: 89%

Comparison of Azithromycin and Amoxicillin Before Dental Implant Placement: An Exploratory Study of Bioavailability and Resolution of Postoperative Inflammation

Escalante

Eubank

Leblebicioğlu

et al. 2015

Journal of Periodontology

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Background Studies suggest that a single prophylactic dose of amoxicillin reduces early implant complications, but it is unclear whether other antibiotics are also effective. This study compared the local antimicrobial and anti-inflammatory effects resulting from a single dose of azithromycin or amoxicillin prior to surgical placement of one-stage dental implants. Methods Healthy adult patients requiring one-stage dental implant placement were randomly allocated to receive either 2g amoxicillin (n=7) or 500mg azithromycin (n=6) prior to surgery. Peri-implant crevicular fluid (PICF) samples from the new implant and gingival crevicular fluid (GCF) from adjacent teeth were sampled on postoperative days 6, 13 and 20. Inflammatory mediators in the samples were analyzed by immunoassay and antibiotic levels were measured by bioassay. Results On day 6, azithromycin concentrations in GCF and PICF were 3.39±0.73μg/ml and 2.77±0.90μg/ml, respectively, while amoxicillin was below the limit of detection. During early healing, patents in the azithromycin group exhibited a significantly greater decrease in GCF volume (p=0.03, ANOVA). At specific times during healing, the azithromycin group exhibited significantly lower levels of IL-6 and IL-8 in GCF than the amoxicillin group and exhibited significantly lower levels of G-CSF, IL-8, MIP-1β and IP-10 in PICF. Conclusions Azithromycin was available at the surgical site for a longer period of time than amoxicillin, and patients taking azithromycin exhibited lower levels of specific pro-inflammatory cytokines and chemokines in GCF and PICF. Thus, preoperative azithromycin may enhance resolution of postoperative inflammation to a greater extent than amoxicillin.

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Early Wound Healing Following One‐Stage Dental Implant Placement With and Without Antibiotic Prophylaxis: A Pilot Study

Abstract: PICF content can be studied as early as 1 week following one-stage implant placement. The results raise doubts regarding the clinical usefulness of amoxicillin prophylaxis.

Cited by 37 publications

References 46 publications

Longitudinal Comparison of Cytokines in Peri‐Implant Fluid and Gingival Crevicular Fluid in Healthy Mouths

Longitudinal Comparison of Cytokines in Peri‐Implant Fluid and Gingival Crevicular Fluid in Healthy Mouths

Current Trend of Antimicrobial Prescription for Oral Implant Surgery Among Dentists in India

Comparison of Azithromycin and Amoxicillin Before Dental Implant Placement: An Exploratory Study of Bioavailability and Resolution of Postoperative Inflammation

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