Early Warning Information for Severe and Critical Patients With COVID-19 Based on Quantitative CT Analysis of Lung Segments

Xu, Yuqian; Lexi, Yu; Wang, Haochu; Shu, Zhenyu; Gong, Xiangyang

doi:10.3389/fpubh.2021.596938

Cited by 8 publications

(10 citation statements)

References 22 publications

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“…We also observed higher levels of α2,6-sialic acid in the lower lobe of the lungs in patients who have died from COVID-19. In previous studies, CT scans showed that lower lobe involvement and consolidation is common in COVID-19 patients 76, 77 . In the lower lobe, staining for α2,6-sialic acid appeared strongest at the barrier of blood-gas exchange.…”

Section: Discussionmentioning

confidence: 88%

α2,6-Sialylation is Upregulated in Severe COVID-19 Implicating the Complement Cascade

Qin

Kurz

Chen

et al. 2022

Preprint

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Better understanding of the mechanisms of COVID-19 severity is desperately needed in current times. Although hyper-inflammation drives severe COVID-19, precise mechanisms triggering this cascade and what role glycosylation might play therein is unknown. Here we report the first high-throughput glycomic analysis of COVID-19 plasma samples and autopsy tissues. We find α2,6-sialylation is upregulated in plasma of patients with severe COVID-19 and in the lung. This glycan motif is enriched on members of the complement cascade, which show higher levels of sialylation in severe COVID-19. In the lung tissue, we observe increased complement deposition, associated with elevated α2,6-sialylation levels, corresponding to elevated markers of poor prognosis (IL-6) and fibrotic response. We also observe upregulation of the α2,6-sialylation enzyme ST6GAL1 in patients who succumbed to COVID-19. Our work identifies a heretofore undescribed relationship between sialylation and complement in severe COVID-19, potentially informing future therapeutic development.

show abstract

Section: Discussionmentioning

confidence: 88%

α2,6-Sialylation is Upregulated in Severe COVID-19 Implicating the Complement Cascade

Qin

Kurz

Chen

et al. 2022

Preprint

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“…This may be due to the physiologic regional inhomogeneity of the lung as a result of the influence of gravity [ 33 ]. The erect lung is marked by striking regional non-uniformity in perfusion and ventilation resulting in blood flow and ventilation predominating in the lower lobes [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Pediatric COVID-19 Follow-Up with Lung Ultrasound: A Prospective Cohort Study

Regina

Pepino²,

Nenna³

et al. 2022

Diagnostics

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During the COVID-19 pandemic, lung ultrasound (LUS) was widely used to assess SARS-CoV-2 infection. To date, there are patients with persistence of symptoms after acute infection. Therefore, it may be useful to have an objective tool to follow these patients. The aim of our study was to evaluate the presence of LUS artifacts after SARS-CoV-2 infection in children and to analyze the associations between time elapsed since infection and symptomatology during acute infection. We conducted an observational study, enrolling 607 children infected with SARS-CoV-2 in the previous twelve months. All patients performed a LUS and medical history of demographic and clinical data. We observed irregular pleural lines in 27.5%, B-lines in 16.9%, and subpleural consolidations in 8.6% of the cases. These artifacts were more frequently observed in the lower lobe projections. We have observed that the frequency of artifacts decreases with increasing time since infection. In symptomatic patients during COVID infection, B-lines (p = 0.02) were more frequently found. In our sample, some children, even after months of acute infection, have ultrasound artifacts and showed an improvement with the passage of time from the acute episode. Our study provides additional evidence about LUS in children with previous COVID-19 as a support to follow these patients in the months following the infection.

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“…Severe and critical cases were combined into the same group in this study. We did not consider CT score [ 4 , 5 ] in the classification of COVID-19 severity.…”

Section: Methodsmentioning

confidence: 99%

Severity predictors of COVID-19 in SARS-CoV-2 variant, delta and omicron period; single center study

Ogawa

Oi²,

Honzawa³

et al. 2022

PLoS ONE

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Background The outcomes of coronavirus disease 2019 (COVID-19) treatment have improved due to vaccination and the establishment of better treatment regimens. However, the emergence of variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, and the corresponding changes in the characteristics of the disease present new challenges in patient management. This study aimed to analyze predictors of COVID-19 severity caused by the delta and omicron variants of SARS-CoV-2. Methods We retrospectively analyzed the data of patients who were admitted for COVID-19 at Yokohama City University Hospital from August 2021 to March 2022. Results A total of 141 patients were included in this study. Of these, 91 had moderate COVID-19, whereas 50 had severe COVID-19. There were significant differences in sex, vaccination status, dyspnea, sore throat symptoms, and body mass index (BMI) (p <0.0001, p <0.001, p <0.001, p = 0.02, p< 0.0001, respectively) between the moderate and severe COVID-19 groups. Regarding comorbidities, smoking habit and renal dysfunction were significantly different between the two groups (p = 0.007 and p = 0.01, respectively). Regarding laboratory data, only LDH level on the first day of hospitalization was significantly different between the two groups (p<0.001). Multiple logistic regression analysis revealed that time from the onset of COVID-19 to hospitalization, BMI, smoking habit, and LDH level were significantly different between the two groups (p<0.03, p = 0.039, p = 0.008, p<0.001, respectively). The cut-off value for the time from onset of COVID-19 to hospitalization was four days (sensitivity, 0.73; specificity, 0.70). Conclusions Time from the onset of COVID-19 to hospitalization is the most important factor in the prevention of the aggravation of COVID-19 caused by the delta and omicron SARS-CoV-2 variants. Appropriate medical management within four days after the onset of COVID-19 is essential for preventing the progression of COVID-19, especially in patients with smoking habits.

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Early Warning Information for Severe and Critical Patients With COVID-19 Based on Quantitative CT Analysis of Lung Segments

Cited by 8 publications

References 22 publications

α2,6-Sialylation is Upregulated in Severe COVID-19 Implicating the Complement Cascade

α2,6-Sialylation is Upregulated in Severe COVID-19 Implicating the Complement Cascade

Pediatric COVID-19 Follow-Up with Lung Ultrasound: A Prospective Cohort Study

Severity predictors of COVID-19 in SARS-CoV-2 variant, delta and omicron period; single center study

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