Early Visual and Morphologic Changes After Half-Fluence Photodynamic Therapy in Chronic Central Serous Chorioretinopathy

Abstract

The SFCT in the symptomatic eyes was greater in the fellow eyes at baseline. Functional and morphological chorioretinal changes started in very early period of treatment. Half-fluence PDT for chronic CSC resulted in thinner CFT and SFCT, and also showed a significant improvement in visual acuity.

The time of resolution and the rate of recurrence in acute central serous chorioretinopathy following spontaneous resolution and low-fluence photodynamic therapy: a case–control study

“…Although RPE dysfunction theory has yielded more attention for several years, choroidal thickness theory has become more important after the results of indocyanine green angiography (ICGA) and the enhanced depth imaging optical coherence tomography (OCT) studies. [3][4][5] In CSC patients, choroidal vascular abnormalities and leakage were shown via ICGA, and subfoveal choroidal thickness was found to be thicker via enhanced depth imaging OCT, two essential findings which further supported the role of choroidal dysfunction in the pathogenesis. [3][4][5] Taking into account the importance of a normal functioning RPE which quickly absorbs the subretinal fluid (SRF), it is not possible to completely reject the RPE theory.…”

“…9 As a general characteristic, the choroidal thickness was shown to be increased in pachychoroid pigment epitheliopathies. [3][4][5][6][7]9 It is well known that photodynamic therapy targets primarily the choroid. The choroidal leakage and thickness were shown to be decreased after PDT in patients with polypoidal choroidal vasculopathy and CSC.…”

“…The choroidal leakage and thickness were shown to be decreased after PDT in patients with polypoidal choroidal vasculopathy and CSC. 5,10 Kang and Kim 11 reported that the subfoveal choroidal thickness was decreased in both spontaneously resolved and PDT-treated CSC patients. However, the amount of decrease was higher in PDT-treated patients.…”

The role of indocyanine green angiography imaging in further differential diagnosis of patients with nAMD who are morphologically poor responders to ranibizumab in a real-life setting

“…Chronic CSC was diagnosed when enlarged choroidal vessels and leakage from these vessels and hyperfluorescence were detected in the early frames of ICGA, and when wash-out pattern of the leakage and hypofluorescence was detected in the late frames ( Figure 2). 22 Also in a detailed manner, we evaluated all of the ICGA, FA, and OCT images of the patients for the other signs of CSC, such as diffuse hyperfluorescence in FA, gravitational tracts, and pigmentary changes. 22 RAP was diagnosed when a large and high retinal pigment epithelial detachment with a notch on the surface was detected and/or when angioma per se was detected in ICGA as a hot spot ( Figure 3).…”

“…22 Also in a detailed manner, we evaluated all of the ICGA, FA, and OCT images of the patients for the other signs of CSC, such as diffuse hyperfluorescence in FA, gravitational tracts, and pigmentary changes. 22 RAP was diagnosed when a large and high retinal pigment epithelial detachment with a notch on the surface was detected and/or when angioma per se was detected in ICGA as a hot spot ( Figure 3). 16 CNV associated with chronic CSC was diagnosed when a classic CNV was detected with the previously described features of chronic CSC in ICGA.…”