Early versus On-Demand Nasoenteric Tube Feeding in Acute Pancreatitis

Abstract

This trial did not show the superiority of early nasoenteric tube feeding, as compared with an oral diet after 72 hours, in reducing the rate of infection or death in patients with acute pancreatitis at high risk for complications. (Funded by the Netherlands Organization for Health Research and Development and others; PYTHON Current Controlled Trials number, ISRCTN18170985.).

Admission Hematocrit and Rise in Blood Urea Nitrogen at 24 h Outperform other Laboratory Markers in Predicting Persistent Organ Failure and Pancreatic Necrosis in Acute Pancreatitis: A Post Hoc Analysis of Three Large Prospective Databases

“…Th e DPSG cohort consisted of AP patients admitted to any one of the 15 collaborating Dutch hospitals (8 university and 7 major teaching hospitals) from 2004 to 2007 (25)(26)(27). Patients with an initial AP episode were initially screened for participation in a randomized controlled trial evaluating the use of probiotics in severe AP (PROPATRIA trial, registration No.…”

Meta-analysis of early nutrition: the benefits of enteral feeding compared to a nil per os diet not only in severe, but also in mild and moderate acute pancreatitis

“…Thirty-three articles (21 articles containing patients suffering from SAP as well as 12 articles with MAP patients) were selected. They contained two nonrandomized and 31 randomized controlled clinical trials (Table 2) [16][17][18][19][20][21][22][23][24][25][26][27]29,[31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]. Finally, statistical analyses were performed on data from articles where both EN and NPO groups were presented, the trial was randomized, and the relevant data were available.…”

Acute Pancreatitis Patient Registry to Examine Novel Therapies in Clinical Experience (Apprentice): An International Multicenter Consortium for the Study of Acute Pancreatitis

“…Consequently, owing to both the cost and the regu latory burden, many new and existing interventions for AP have not been evaluated rigorously, and the most influential trials have enrolled limited numbers of participants from certain geographical areas [28][29][30]. Registrybased randomized clinical trials have become a powerful tool for increasing the efficiency and cost-effectiveness of clinical trials [31].…”