Early versus delayed cholecystectomy in patients with biliary acute pancreatitis

Nebiker, Christian A.; Hamel, Christian; Oertli, Daniel; Kettelhack, Christoph

doi:10.1016/j.surg.2008.10.012

Cited by 57 publications

(35 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are studies that identify no risk factors for recurrence, and then studies that relate AP recurrence to gallstone size (7), episode severity (8), early reintroduction of food, biochemical changes in liver function, age, or race (9). However, the incidence of AGP recurrence and the time to recurrence are highly variable in reported series (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Influence of delayed cholecystectomy after acute gallstone pancreatitis on recurrence. Consequences of lack of resources

et al. 2016

View full text Add to dashboard Cite

Introduction: Acute pancreatitis is often a relapsing condition, particularly when its triggering factor persists. Our goal is to determine the recurrence rate of acute biliary pancreatitis after an initial episode, and the time to relapse, as well as to identify the risk factors for recurrence. Material and method:We included all patients admitted for a first acute gallstone pancreatitis event during four years. Primary endpoints included readmission for recurrence and time to relapse.Results: We included 296 patients admitted on a total of 386 occasions. The incidence of acute biliary pancreatitis in our setting is 17.5/100,000 population/year. In all, 19.6% of pancreatitis were severe (22.6% of severe acute pancreatitis for first episodes versus 3.6% for recurring pancreatitis), with an overall mortality of 4.4%. Overall recurrence rate was 15.5%, with a median time to relapse of 82 days. In total, 14.2% of patients relapsed after an acute pancreatitis event without cholecystectomy or endoscopic retrograde cholangio-pancreatography. Severe acute pancreatitis recur in 7.2% of patients, whereas mild cases do so in 16.3%, this being the only risk factor for recurrence thus far identified.Conclusions: Patients admitted for pancreatitis should undergo cholecystectomy as soon as possible or be guaranteed priority on the waiting list. Otherwise, endoscopic retrograde cholangio-pancreatography with sphincterotomy may be an alternative to surgery for selected patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Influence of delayed cholecystectomy after acute gallstone pancreatitis on recurrence. Consequences of lack of resources

et al. 2016

View full text Add to dashboard Cite

show abstract

“…25 Delay in cholecystectomy was associated with an increase in biliary complications in patients with non-necrotizing biliary acute pancreatitis. 26 Early confirmation of etiology and ERCP within 48 hours with CBD stones clearance followed by urgent cholecystectomy within 3-9 days gave excellent outcome. 12 In this study early (after subsiding the acute phase) ERCP was done in 14 patients having gall stone to evaluate the pancreaticobiliary system and sphincterotomy was done in two patient who had dilated CBD.…”

Section: Discussionmentioning

confidence: 95%

Clinical Pattern and Management of Acute Pancreatitis Our Experience

Hasan¹,

Laila²,

Mamun

2014

J. Bangladesh Coll. Phys.

View full text Add to dashboard Cite

Background: Acute pancreatitis (AP) is an acute inflammatory condition of the pancreas that may extend to local and distant extrapancreatic tissues. It is a lifethreatening disease that has many causes, few effective treatments, numerous serious complications, and an often unpredictable course. The objectives of this study are to develop our knowledge about presentation and diagnosis of acute pancreatitis, to assess the patient with acute pancreatitis accurately and to develop a standard management protocol. Methods: This observational study was carried out in Combined

show abstract

“…This guidance disregards the parietal inflammatory process itself when it has already associated with metabolic and systemic consequences. Nowadays, early laparoscopic cholecystectomy is the gold standard for treatment of most cases of acute cholecystitis considering its safety and efficacy, reducing the operative time, lowering of conversion rates and costs, accelerating hospital discharge, and decreasing the incidence of biliary complications 32 . In addition, approximately 3% to 10% of patients with biliary lithiasis will develop acute pancreatitis, a risk that is increased up to 20% in male patients in the presence of gallbladder stones smaller than 5 mm 33 .…”

Section: Long-term Therapy With Intravenousmentioning

confidence: 99%

Cholecystectomy during ceftriaxone therapy. A translational study with a new rabbit model

Vasconcellos

Cozer²,

Diniz³

et al. 2017

Acta Cir. Bras.

View full text Add to dashboard Cite

Purpose: To evaluate the actual incidence of both microlithiasis and acute cholecystitis during treatment with intravenous ceftriaxone in a new rabbit model. Methods: New Zealand rabbits were treated with intravenous ceftriaxone or saline for 21 days. Ultrasound monitoring of the gallbladder was performed every seven days until the 21 st day when histopathology, immunohistochemistry for proliferating cell nuclear antigen (PCNA), pro-caspase-3 and CD68, liver enzyme biochemistry, and chromatography analysis of the bile and sediments were also performed. Results: All animals treated with ceftriaxone developed acute cholecystitis, confirmed by histopathology (P<0.05) and biliary microlithiasis, except one that exhibited sediment precipitation. In the group treated with ceftriaxone there was an increase in pro-caspase-3, gammaglutamyl transpeptidase concentration, PCNA expression and in the number of cells positive for anti-CD68 (P<0.05). In the ceftriaxone group, the cholesterol and lecithin concentrations increased in the bile and a high concentration of ceftriaxone was found in the microlithiasis. Conclusion: Ceftriaxone administered intravenously at therapeutic doses causes a high predisposition for lithogenic bile formation and the development of acute lithiasic cholecystitis.

show abstract

Early versus delayed cholecystectomy in patients with biliary acute pancreatitis

Cited by 57 publications

References 29 publications

Influence of delayed cholecystectomy after acute gallstone pancreatitis on recurrence. Consequences of lack of resources

Influence of delayed cholecystectomy after acute gallstone pancreatitis on recurrence. Consequences of lack of resources

Clinical Pattern and Management of Acute Pancreatitis Our Experience

Cholecystectomy during ceftriaxone therapy. A translational study with a new rabbit model

Contact Info

Product

Resources

About

Early versus delayed cholecystectomy in patients with biliary acute pancreatitis

Cited by 57 publications

References 29 publications

Influence of delayed cholecystectomy after acute gallstone pancreatitis on recurrence. Consequences of lack of resources

Influence of delayed cholecystectomy after acute gallstone pancreatitis on recurrence. Consequences of lack of resources

Clinical Pattern and Management of Acute Pancreatitis  Our Experience

Cholecystectomy during ceftriaxone therapy. A translational study with a new rabbit model

Contact Info

Product

Resources

About

Clinical Pattern and Management of Acute Pancreatitis Our Experience