Early vascular injury in the X‐irradiated chick embryo: An electron‐microscope study

Stearner, S.P.; Sanderson, Margaret H.

doi:10.1002/path.1710990305

Cited by 9 publications

(1 citation statement)

References 14 publications

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“…The ultrastructural changes in the endothelial cells consisted of increased vacuolisation, dilated and disrupted mitochondria, dilated endopiasmic reticuium, oedema and lo' SS of cytoplasmic density leading finally to necrosis. This progression of events in endothelial cells is similar to that described by Steamer and Sanderson (1969) following radiation exposure. Similar lesions have been reported when energy metabolism is in-hibited (Crocker, Saladino & Trump 1970) or when vessels are subjected to anoxia (Hills 1964) although in this latter condition the development of vessel damage was much slower than that following freezing.…”

Section: Discussionsupporting

confidence: 79%

Ultrastructural changes in the microvasculature following cryosurgery of oral mucosa

Whittaker¹

1975

J of Periodontal Research

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Ultrastructural studies on vessels in oral mucosa subjected to surface freezing were carried out. Only minor changes were visible in the first 30 mins. post operatively but after this time both capillaries and venules were involved in a delayed prolonged response which was similar in character to that following certain other stimuli but which had some unique characteristics. The deposition of carbon in these experiments was compatible with increased permeability of the vessels and the ensuing lack of carbon labelling was shown to be due to the onset of platelet thrombosis. Structural endothelial damage was produced following the freezing episode and occurred prior to the time expected if anoxia were the reason for the vessel damage. There was no evidence that the presence of ice crystals during freezing produced direct rupture of vessels.

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Section: Discussionsupporting

confidence: 79%

Ultrastructural changes in the microvasculature following cryosurgery of oral mucosa

Whittaker¹

1975

J of Periodontal Research

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Vasculogenesis in the chick embryo. An ultrastructural study

González-Crussí

1971

Am. J. Anat.

108

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The morphogenesis of the extra-embryonic circulatory system of the chick was studied by light and electron microscopy, from precirculatory stages until the beginning of the definitive circulation. Early mesodermal migrations of prospective vasoformative cells and formation of blood islands take place with minimal morphologically expressed cytodifferentiation. The earliest mesodermal clusters are not syncytial. Formation of vascular lumina is not due to lysis of central cells. Undifferentiated mesenchyme possesses the capacity to establish complex junctional devices at points of contact with like cells. The first formed blood islands show intimate relationships with endoderm. The initial capillary network is sinusoidal in type, the endothelium being unsupported by a basement membrane. The major vitelline vessels acquire a more complex anatomy but the capillaries retain this simple pattern throughout the period studied. Several phases in the histogenesis of vitelline vessels are recognized, which could be correlated with the known progression of arterial pressure patterns. Continuing differentiation and mesenchymal investment of vascular walls, after stages 22-23 of Hamburger and Hamilton ('511, in correspondence with the last sustained pressure elevation, leads to completion of the adult vascular structure.

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Microvasculature and loose connective tissue in freeze-fracture preparations

Stearner

Sanderson

1971

Z. Zellforsch.

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Early vascular injury in the X‐irradiated chick embryo: An electron‐microscope study

Cited by 9 publications

References 14 publications

Ultrastructural changes in the microvasculature following cryosurgery of oral mucosa

Ultrastructural changes in the microvasculature following cryosurgery of oral mucosa

Vasculogenesis in the chick embryo. An ultrastructural study

Microvasculature and loose connective tissue in freeze-fracture preparations

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